WEIGHT LOSS

This study will test if combining GLP-1 medications (like semaglutide and tirzepatide) with Noom's digital health program helps people with obesity lose weight and improve health markers like blood sugar and cholesterol. About 2,310 adults will be followed for 24 months. The goal…

This study tests whether tracking only high-calorie, low-nutrition foods (simplified approach) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if the simpler…

This study will test if a procedure called endoscopic sleeve gastroplasty (ESG) is safe and works well for weight loss in Asian adults with obesity. The procedure uses a special stitching tool to make the stomach smaller. About 136 people will take part, and the main goal is to s…

This study tests a 10-week behavioral program to help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. About 64 adults who lost at least 15% of their body weight on these drugs will be randomly assigned to extra support like tailored meals, gym …

This study tests a device called Orbera365, a balloon placed in the stomach to help people with obesity lose weight. It involves 144 adults with a BMI between 28 and 50 who have not succeeded with diet and exercise alone. The main goal is to see if the balloon helps them lose at …

This study tests whether giving a daily probiotic supplement to 180 healthy full-term babies born by C-section can help them gain weight, reduce colic and spitting up, and improve their gut health. The babies will receive either one of two probiotic blends or a placebo for the fi…

This study aims to find the best combination of four dietary strategies—limiting high-calorie foods, eating within a set time window, increasing protein, and increasing fiber—for weight loss in adults with overweight or obesity. Over 12 weeks, 208 participants will track their we…

This study looks at how two different weight loss methods—medication (GLP-1 drugs like Ozempic) and bariatric surgery—change pelvic floor symptoms like bladder leaks, urgency, and prolapse in women. About 200 women aged 18 to 89 with a BMI of 30 or higher will join. The goal is t…

This study is testing whether a well-known community weight loss program called TOPS can be adapted to better help breast cancer survivors lose weight. Researchers will first get feedback from survivors in focus groups, then use that feedback to run tailored TOPS classes. The goa…

This study tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves health. About 1,040 mothers in Côte d'Ivoire will either receive the reward plus education or just education. Researchers will tra…

This study will use ultrasound to take pictures of the stomach in 10 patients who are having weight-loss surgery. The goal is to learn how the stomach looks before and after the operation. Patients will be asleep during the imaging, so there is little discomfort.

This early-stage study looks at how the body processes HRS9531, a drug for diabetes and weight loss, in people with mild or moderate liver issues compared to those with healthy livers. About 24 adults will receive a single dose to measure drug levels and check for side effects. T…