WEIGHT LOSS

This study looks at how well a weight-loss program works for children and teens (ages 2-18) who are overweight or have obesity. The program is run by local municipalities or hospitals in Denmark and focuses on helping kids achieve a healthier weight and lifestyle. Researchers wil…

This study looked at whether two probiotics, TCI378 and TCI507, can help adults lose weight. About 96 adults with a BMI of 24 or higher or high body fat took part. Researchers measured changes in body fat, cholesterol, and other health markers to see if the probiotics made a diff…

This study tests an investigational drug called VK2735 to help people with type 2 diabetes who are overweight or obese lose weight. About 1,100 adults will receive either the drug or a placebo injection weekly for 78 weeks. The main goal is to see how much weight they lose and if…

This study looks at whether starting with a parent-only weight loss program, then adding a parent-child program, works better than the parent-child program alone. About 480 rural families with an overweight child (ages 6-11) and a parent with overweight will participate through v…

This study planned to help toddlers with obesity by improving what they eat. Parents would join a free online nutrition program and could also take weight-loss medication. The idea was that helping parents eat better would also improve their toddler's diet and weight. However, th…

This study tests a new medication called VK2735 to help people with obesity or overweight lose weight. About 4500 adults who are obese or overweight with related health issues (like high blood pressure) will receive weekly injections of the drug or a placebo for 78 weeks. The mai…

This study tests whether a game-like mobile app, combined with brain-training games, can help overweight men lose weight and keep it off. About 228 men will use either a standard weight-loss app or a gamified version with team challenges and rewards. The goal is to see if making …

This study tests whether a weight loss program delivered through a patient portal can help overweight adults lose weight and lower their cancer risk. About 229 participants will be randomly assigned to either an active program with coaching and tools or a comparison group with ba…

This study is testing a smartphone app that uses artificial intelligence and cognitive behavior therapy to help people with obesity lose weight and improve body composition. The app tracks food and mood through photos and provides personalized guidance. One hundred adults aged 18…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 weight-loss drugs like tirzepatide. About 246 adults who have been on these drugs for at least 3 months will either receive a multivitamin or a placebo for 1…

This study tests a new medication called aleniglipron in adults with type 2 diabetes who are also overweight or have obesity. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure changes in body weight and blood sugar level…

This study compares time-restricted eating (eating only during a set daily window) to traditional calorie counting for weight loss and reducing colorectal cancer risk. About 193 adults with obesity, aged 45-70, will follow one of the two diets for a period. The goal is to see if …

This study looks at whether helping overweight or obese women lose about 10% of their body weight before getting pregnant can lower the chance of their baby being born with too much body fat or becoming overweight in early childhood. About 240 women (and their partners, if they c…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can ease severe fatigue in people with advanced solid tumors that cannot be cured. About 129 participants will receive the combination for several weeks, and researchers…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who are losing weight. About 98 patients will receive either mirtazapine or a placebo for 15 to 29 days. The goal is to see if it helps with appetite, sl…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) before and after a type of weight-loss surgery called sleeve gastrectomy. About 30 adults who are overweight and have NASH or prediabetes will take part. Th…

This study looks for biological markers that may explain why some people experience a larger-than-expected drop in their resting metabolism when they lose weight. Researchers will follow 60 adults with obesity for 18 months, measuring metabolism and hormone levels. The goal is to…

This study follows 500 adults with obesity who are trying to lose weight. Researchers collect data on their health, habits, and blood tests to find out what helps or hinders weight loss. The goal is to create personalized weight loss plans based on each person's unique profile.

This study will follow 5,000 adults who have had an endoscopic procedure for weight loss or to fix a previous weight-loss surgery. Researchers will track changes in weight, blood pressure, diabetes, and cholesterol for up to 10 years. The goal is to learn how well these procedure…

This study looks at how the weight-loss drug lorcaserin affects brain areas that control appetite and eating. About 40 adults with obesity will have brain scans (fMRI) and body composition tests before and after treatment. The goal is to understand the brain changes behind the dr…