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Gut bacteria pills could help shed pounds, small study hints

NCT ID NCT04492605

Disease control Sponsor: TCI Co., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether two probiotic supplements, TCI378 and TCI507, can help adults lose weight and improve blood fats. 96 participants with a BMI of 24 or higher (or high body fat) take one capsule daily for two months. Researchers will measure changes in body fat, cholesterol, and other health markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotics (TCI378 and TCI507)
What this could lead to
If successful, these probiotics could offer a safe, natural option to help with weight management and improve cholesterol levels.
What could go wrong
This is a small, early-stage trial with no blinding, so results may be influenced by placebo effects. Weight loss from probiotics is typically modest and not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

96 people

The number who actually took part.

Started

Mar 2022

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults between the ages of 20 and 65 who are willing to sign the consent form of the subject. 2. BMI ≥ 24 or male body fat ≥ 25%, female body fat ≥ 30%. 3. Those who are not pregnant and are willing to cooperate with contraception during the trial period. 4. No history of cardiovascular disease, history of organ transplantation, history of epilepsy or convulsions, liver and kidney disease, malignant tumor, endocrine disease, mental disease, alcohol or drug abuse, or other major organic diseases (according to medical history). Exclusion Criteria: 1. Pregnant women, people with a history of cardiovascular disease, organ transplantation, epilepsy or convulsions, liver and kidney disease, malignant tumors, endocrine diseases, mental diseases, alcohol or drug abuse, and other major organic diseases (according to medical history). 2. No person who has undergone major surgery or bariatric surgery (according to medical history). 3. Drugs that affect body fat, waist circumference, or significantly increase weight, such as systemic corticosteroids, tricyclic antidepressants, atypical psychiatric drugs, and mood stability, have been used at present or within 3 months before participating in the screening Drugs (according to medical history).

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Conditions

The condition(s) this trial relates to.

Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weight loss

Contacts and locations

Locations

  • National Taiwan University Hospital

    Taipei, Taiwan, 114, Taiwan

  • National Taiwan University Hospital

    Taipei, Taiwan

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