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Rare gut condition: which surgery works best?

NCT ID NCT06970093

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two surgeries—One Anastomosis Gastric Bypass and Duodenojejunostomy—for treating Superior Mesenteric Artery Syndrome (SMAS), a rare condition where the duodenum is compressed, causing severe nausea, vomiting, and weight loss. Twenty participants were randomly assigned to one surgery and followed for 12 months to see which better improves symptoms and nutrition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
One Anastomosis Gastric Bypass (OAGB) and Duodenojejunostomy (DJ) surgeries
What this could lead to
If this trial succeeds, it could show which surgery is more effective for treating SMAS, helping patients get better symptom relief and nutritional recovery.
What could go wrong
This is a small study with only 20 participants, so results may not apply to everyone. Both surgeries are invasive and carry risks like infection or complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Mar 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of Superior Mesenteric Artery Syndrome (SMAS) based on symptoms and radiologic findings * No prior gastric or intestinal surgery * Willingness and ability to participate in follow-up for 12 months Exclusion Criteria: * Presence of other gastrointestinal pathologies mimicking SMAS * Severe comorbidities contraindicating surgery (e.g., advanced cardiac or pulmonary disease) * History of previous bariatric or upper GI surgery * Refusal or inability to provide informed consent

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Conditions

The condition(s) this trial relates to.

digestive system disorder duodenal obstruction intestinal obstruction Malnutrition superior mesenteric artery syndrome Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Duodenal obstruction Gastrointestinal disease Superior mesenteric artery syndrome Weight loss

Contacts and locations

Locations

  • Ain Shams University Hospitals

    Cairo, Cairo Governorate, 11566, Egypt

More trials for these conditions

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