ULCERATIVE COLITIS

This study tested whether mirikizumab, a biologic drug, can improve symptoms and gut healing in 100 people with moderate-to-severe ulcerative colitis who had a specific type of inflammation seen on biopsy. Participants received either mirikizumab or vedolizumab, and doctors track…

This study tested whether rutin, a natural compound found in plants, can reduce inflammation and improve symptoms in people with ulcerative colitis. 60 adults with confirmed UC took rutin to see if it could lower disease activity. The goal was to help patients feel better and red…

This study looked at the long-term safety of the drug vedolizumab in children aged 2 to 17 with ulcerative colitis or Crohn's disease. A total of 59 children who had already responded to the drug in an earlier study were followed to see how many had side effects. The main goal wa…

This study looked at how safe and effective the drug upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 105 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to…

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it takes hold in the body. Participants received either MB310 or a placebo, and researchers monitored side effects…

This study looked at how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis. About 300 people in Japan took Rinvoq as part of their normal care and were followed for up to 60 weeks. The main goal was to track serious infections and other s…

This study tested switching 38 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) from intravenous infliximab to a subcutaneous (under-the-skin) injection. Researchers measured drug levels, quality of life, and patient satisfaction over 24 weeks. The goal was …

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like infliximab or vedolizumab helps people with moderate to severe ulcerative colitis achieve endoscopic remission (healing of the gut lining). The trial enrolled 438 adults…

This study tested a drug called mirikizumab in 63 children aged 2 to 17 with moderate to severe ulcerative colitis, a condition causing inflammation in the colon. The goal was to see if the drug can help control the disease and improve symptoms over 52 weeks. Participants had alr…

This study tested a daily medication called ABX464 in 639 people with moderate to severe ulcerative colitis. The goal was to see if it could help bring the disease under control (remission) within 8 weeks, compared to a placebo. Participants had not responded well to other treatm…

This study tested a daily pill called ABX464 in 217 adults with moderate to severe ulcerative colitis who had already completed 16 weeks of treatment. The goal was to see if the drug could keep the disease in remission for up to 96 weeks. Researchers measured remission using a st…

This study tested a drug called TA-650 in 21 children with moderate to severe ulcerative colitis, a condition causing inflammation and sores in the colon. The goal was to see if the drug could reduce disease activity and improve symptoms. Children received the drug by infusion at…

This study tested a web-based telemonitoring system (TECCU) for people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis). 290 adults who were starting or continuing immunosuppressant or biologic therapy were randomly assigned to use the TE…

This study tested an experimental drug called ABBV-668 in 30 adults with moderate to severe ulcerative colitis, a condition that causes inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks, and researchers checked for side effects and signs …

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis stay in remission (symptom-free) after they had already responded to an initial treatment. About 1,300 adults who completed a prior induction study were randomly assigned to receive m…

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic condition causing inflammation in the colon. 85 participants received either donor or their own stool via tubes and enemas. The goal was to see if donor transplant…

This study looked at the long-term safety and effectiveness of the drug Entyvio (vedolizumab) in over 1,100 people with moderate to severe ulcerative colitis. Participants received the drug as part of their normal medical care. The main goal was to track any side effects and see …

This study tested an oral medication called amiselimod (MT-1303) against a placebo in 322 adults with mild to moderate ulcerative colitis. The goal was to see if the drug could reduce disease activity over 12 weeks, with an option to continue treatment for up to 36 weeks. The tri…

This study looked at the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It included 877 adults who had already taken part in earlier RPC1063 trials. The goal was to see how well the drug controls the …

This study tested whether people with ulcerative colitis can prevent symptom flare-ups by regularly testing their stool at home for signs of inflammation. Over 700 adults in remission used a smartphone-based test kit to catch inflammation early, allowing doctors to adjust treatme…

This study tested the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still had bowel urgency despite other treatments. The main goal was to see if the drug reduces the sudden, urgent need to use the bathroom. Participants were followed for 36 weeks …

This study tested a new daily pill, ABX464, for people with moderate to severe ulcerative colitis who did not get better with other treatments. About 636 adults and teens took either 25 mg, 50 mg, or a placebo for 8 weeks. The main goal was to see if the drug could help achieve r…

This study tested an experimental drug called ABX464 in 355 adults with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could reduce symptoms like diarrhea, bleeding, and colon inflammation. Participants receiv…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This study followed 152 adults with moderate to severe ulcerative colitis for two years to see how well tofacitinib works in everyday medical practice. Researchers measured symptom improvement and whether patients could avoid surgery or stronger medications. The goal was to under…

This study looked at the long-term safety of adalimumab, a medicine that blocks inflammation, in 59 children with ulcerative colitis who had already completed an earlier study. Researchers tracked side effects and how well the drug controlled the disease over time. The goal was t…

This study looked at whether regularly measuring the amount of anti-TNF medication and related antibodies in the blood can help doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. About 260 patients were split into two groups: one where …

This study looked at whether probiotics could help people with ulcerative colitis stay in remission. Researchers followed 70 Egyptian adults for one year, checking their disease activity, body mass index, and gut bacteria. The goal was to see if probiotics could help control the …

This study looked at four substances in the blood (Osteoprotegerin, sRANKL, NFkB, and TFF3) to see if they could help diagnose inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patient…

This early-phase study tested whether TUDCA, a bile acid supplement, is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults took TUDCA for 6 weeks while researchers measured changes in cell stress markers from colon biopsies. The goal…

This study looked at whether eating gluten-free for one week can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults with the condition ate a gluten-free diet plus special granola bars—first without gluten, then with high gluten. They filled ou…

This study tested whether eating steamed broccoli sprouts daily for 28 days could increase anti-inflammatory compounds in the blood and stool of people with mild ulcerative colitis. 23 participants took either 1 or 3 servings of sprouts per day. The goal was to see if this diet i…

This study tested whether a physiotherapist-led program, including pelvic floor muscle training, could improve bowel function in people who had ileo-anal pouch surgery. 53 patients who had ulcerative colitis or familial adenomatous polyposis took part. The program was compared to…

This study tested whether a prebiotic (a type of fiber that feeds good gut bacteria) can improve symptoms in people with mild to moderate ulcerative colitis. 38 adults took either the prebiotic or a placebo for four weeks, then switched. Researchers measured symptom changes, gut …

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This study looked at whether a short-term, low-calorie plant-based diet (called a fasting mimicking diet) could help reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD completed three 5-day diet cycles. R…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This completed study in Sweden observed 102 people with ulcerative colitis who were prescribed tofacitinib as part of their normal care. Researchers used a national registry to track how well the drug controlled disease activity and whether patients stayed on treatment. The goal …

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to see if certain advanced treatments lead to more infections. Researchers compared patients taking ENTYVIO, TNF-alpha inhibitors, or ustekinumab using Medicare claims data from 2016 …

This study tested a new endoscopic scoring system called CAT-DESIRE for ulcerative colitis. Researchers reviewed colonoscopy images from 235 patients to see if the new score is reliable and can predict long-term outcomes. The goal is to provide a simple, accurate tool for doctors…

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study looked at tiny, lab-grown versions of the intestine called organoids, made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), a genetic polyp condition (FAP), and healthy volunteers. The goal was to understand how intestinal …

This study looked at 220 children with inflammatory bowel disease (IBD) that is in remission to see how many also have disorders of gut-brain interaction (DGBIs), such as irritable bowel syndrome. Researchers compared them to healthy children to find out if these gut-brain issues…

This study reviewed medical records of 966 children diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. Researchers looked at how often children needed surgery and how treatments like immunosuppressants and anti-TNF drugs were used over time. The goal was …

This study tested whether simple, low-cost blood test ratios (like CRP-to-albumin) can accurately measure ulcerative colitis disease activity. Researchers compared these blood markers with standard colonoscopy and stool tests in 80 patients. The goal was to find a less invasive w…

This study looked at over 107,000 people in Germany to understand the long-term side effects of steroid medications (glucocorticoids) used for conditions like asthma, arthritis, and lupus. Researchers compared those who took steroids with those who did not, tracking problems like…

This completed Phase 2 trial tested whether Aquamin, a mineral supplement, changes how leaky the gut is in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy individuals. 35 participants took Aquamin for 90 days, and researchers measured gut perme…

This study took small tissue samples from 16 people with or without inflammatory bowel disease during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how radiation and potential treatments affect these organoids…

This study watched 165 people with inflammatory bowel disease (IBD) in Poland who were already taking or starting vedolizumab. Researchers did not give any treatment—they simply recorded whether patients chose intravenous (IV) infusions at a clinic or subcutaneous (SC) shots at h…

This study looked at how well two newer biologic drugs (ustekinumab and vedolizumab) work for Crohn's disease in 50 Chinese patients. Researchers checked for things like healing of the gut lining and symptom improvement, and also looked for side effects. The goal was to find out …

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study looked at 343 adults who had inflammatory bowel disease (Crohn's or ulcerative colitis) as children. Researchers wanted to see if their illness affected their jobs and education compared to the general population. They used surveys to collect information on work status…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This early-stage study tested whether the oral biologic MB-001 is safe in 48 healthy adults aged 18 to 65. Participants received either a single dose or five daily doses of the drug or a placebo, and were monitored for side effects. The goal was to gather safety data before testi…