ULCERATIVE COLITIS

This early study tests CP101, a pill made from healthy gut bacteria, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the bacteria can safely take hold in the gut and help control the disease. Participants receive either a short or extended course of C…

This study tests whether transferring healthy stool bacteria (fecal transplant) can help people with ulcerative colitis, a chronic gut disease. About 150 adults with active symptoms will receive either a real transplant or a sham procedure. The goal is to see if the treatment can…

This study was designed to see if adding MitoQ (a daily antioxidant capsule) to standard treatment can help children and teens with mild-to-moderate ulcerative colitis feel better and need fewer steroids. Participants would have taken MitoQ or a placebo for 24 weeks alongside the…

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard treatment can help people with severe ulcerative colitis or hard-to-treat inflammatory bowel disease. About 44 participants will be randomly assigned to get e…

This study looks at the long-term safety and effectiveness of the drug etrasimod for people with moderate to severe ulcerative colitis. About 896 participants who were in earlier studies will take etrasimod daily for up to 104 weeks. The goal is to see if the drug can help contro…

This study looks at the long-term safety and effectiveness of a daily pill called ABX464 for people with moderate to severe ulcerative colitis. About 200 participants who already improved in earlier studies will take the drug for up to 54 months. The goal is to see if the drug re…

This study tests a treatment called fecal microbiota transplant (FMT) in children aged 3 to 21 who have recurrent or severe C. difficile infection, with or without inflammatory bowel disease (IBD). The goal is to see if FMT is safe and can stop the infection from coming back bett…

This study looks at whether taking a common ulcerative colitis medication (5-ASA) in the morning versus the evening affects gut inflammation and medicine levels. About 32 adults with inactive UC but signs of low-level inflammation will take the pill at different times for one mon…

This study tests an oral medication called tofacitinib in children aged 2 to 17 with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if the drug can help achieve and maintain remission (fewer symptoms and healed gut lining) over 44 weeks. About …

This study tests an oral medication called upadacitinib (RINVOQ) in children aged 2–17 with moderate-to-severe ulcerative colitis who haven't responded to standard treatments. The trial has three parts: an 8-week open-label phase where all kids get the drug, a 44-week blinded pha…

This study looks at how well and how safely the drug mirikizumab works over the long term (up to 3 years) for people with moderate to severe ulcerative colitis. About 1,058 adults who were already in earlier studies will continue taking the drug. The goal is to see if it can keep…

This study follows about 500 adults with moderate to severe ulcerative colitis who are starting filgotinib. Researchers want to see how long patients stay on the drug, how well it controls symptoms, and how it affects quality of life in everyday medical practice. The goal is to u…

This study looks at whether avoiding gluten can slow disease progression and ease symptoms in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Researchers will track changes in liver enzymes, gut bacteria, and intestinal inflammation in 60 ad…

This study tests whether atorvastatin, a widely used cholesterol medication, can lower the risk of colon cancer in people with long-standing ulcerative colitis who carry a specific genetic change (P53 mutation). About 42 participants will take either atorvastatin or a placebo for…

This study tests whether mirikizumab can reduce the sudden, urgent need to use the bathroom in adults with moderate to severe ulcerative colitis. About 172 participants will receive the drug and report their urgency levels over 36 weeks. The goal is to see if the drug improves th…

This study is testing a special temperature-sensing probe that can be used during a routine colonoscopy to measure heat in the lining of the colon. The goal is to see if this probe can help doctors detect inflammation in people with inflammatory bowel disease (IBD), including Cro…

This study watches over 1,000 adults with ulcerative colitis or Crohn's disease in Brazil who are taking or have taken vedolizumab. Researchers are not giving any new treatment—they are just collecting information to see how long people stay on the drug and what other treatments …

This study is a long-term registry that follows nearly 5,000 children with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) to monitor their safety and health over time. Researchers collect information on side effects from treatments like inflixi…