ULCERATIVE COLITIS

This study tests whether taking frozen capsules containing filtered or whole stool from healthy donors can help people with mild-to-moderate active ulcerative colitis achieve remission. About 129 adults who have not responded to standard treatments will receive either the stool c…

This study looks at how well risankizumab works for adults with moderate to severe ulcerative colitis in everyday medical practice. About 200 participants will receive the drug as prescribed by their doctor and be followed for up to 52 weeks. The main goal is to see if symptoms l…

This study tests an experimental drug called RO7837195 in people with moderate-to-severe ulcerative colitis who haven't responded to other treatments. About 224 participants will receive either the drug or a placebo for 12 weeks to see if it can bring the disease under control an…

This study tests a daily pill called filgotinib (200 mg) in about 94 Korean adults with moderate-to-severe ulcerative colitis. The main goal is to see if the drug can bring about remission (symptom relief and healing) by week 10 or 22. Participants take the pill as part of their …

This study tests a subcutaneous (under the skin) version of vedolizumab in children aged 2-17 with moderate to severe ulcerative colitis or Crohn's disease. About 70 participants who already responded to IV vedolizumab will receive the shot for up to 34 weeks. The goal is to see …

This study tests whether adding an experimental drug (LY4268989) to an existing treatment (mirikizumab) works better than the existing treatment alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab …

This study looks at how well the drug upadacitinib (RINVOQ) controls symptoms of ulcerative colitis, a condition causing inflammation and bleeding in the colon. About 400 adults in Germany, Austria, and Switzerland who are already prescribed the drug will be followed for up to 2 …

This study tests a new drug called SAR442970 in 99 adults with moderate to severe ulcerative colitis. The goal is to see if different doses can help reduce symptoms and improve the lining of the colon compared to a placebo. The study lasts up to 168 weeks, with an initial 16-week…

This study tests a daily pill called filgotinib in about 80 children aged 8 to 17 with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if the drug can reduce symptoms and keep the disease under control. Participants take the medicine at home and…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with other…

This study looks at whether cutting out certain food additives (emulsifiers like carrageenan, CMC, and polysorbates) can help people with mild-to-moderate ulcerative colitis. About 70 participants will eat either a normal healthy diet or one without these additives for one month.…

This study tests whether combining two drugs—vedolizumab and tofacitinib—can help adults with moderate to severe ulcerative colitis achieve remission. Participants receive both drugs for 8 weeks, then those who respond continue with vedolizumab alone for 44 weeks. The goal is to …

This study tests an oral medication called TAK-279 in people with moderate to severe ulcerative colitis. The goal is to see if it reduces bowel inflammation and symptoms better than a placebo. About 207 adults will take the drug or placebo for 12 weeks, then all receive TAK-279 f…

This program offers children and teenagers with moderate to severe ulcerative colitis or Crohn's disease continued access to vedolizumab, a medication given through a vein, after they finish a related study. It is for those who still benefit from the treatment and have no good al…

This study compares a single fecal transplant versus multiple transplants to treat repeat C. diff infections in 64 adults with ulcerative colitis. Both groups receive donor stool via colonoscopy, but one group gets extra doses. The goal is to see which approach clears the infecti…

This study tests whether adding fermented foods like yogurt, kimchi, and sauerkraut to the diet can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. About 21 adults with confirmed UC will eat fermented foods for a period while re…

This study looks at whether sleep changes can act as early warning signs for flare-ups in people with inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers will track 216 patients in remission for one year, using sleep monitors and questionnai…

This observational study aims to understand how nutrition and body composition impact clinical outcomes in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical therapy or unde…

This study looks at whether people with certain cancers prefer getting their immunotherapy as a shot under the skin (subcutaneous) or through an IV drip. About 880 patients will try both methods and report which they like better. The goal is to understand patient preferences, not…

This study tests whether nicotinamide riboside, a vitamin-like supplement, is feasible to use in children and teens with mild to moderate ulcerative colitis. Researchers will track how many patients enroll and complete the study, and look at changes in cell energy centers (mitoch…

This study looks at how having inflammatory bowel disease (Crohn's or ulcerative colitis) as a child affects job and education outcomes in adulthood. Researchers will survey 460 adults diagnosed before age 17 to compare their work and school achievements with the general populati…

This study looks at how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimental t…

This study follows 450 adults who have early signs of inflammatory bowel disease (IBD) but no symptoms yet. Researchers want to learn how the disease changes over time and what factors lead to symptoms or complications. Participants will provide blood, tissue, and stool samples f…

This study looks at whether robotic surgery is a good option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to the standard laparoscopic (keyhole) approach, measuring things like blood l…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers will identify which T-cells are attacking the body and what they target. The goal is to discover new targets for future treatmen…