ULCERATIVE COLITIS

This study tests whether adding the deworming drug mebendazole to standard mesalamine treatment can improve symptoms in people with mild-to-moderate ulcerative colitis. 46 adults will take mebendazole or a placebo twice daily for 6 months. Researchers will measure changes in dise…

This study tests a new drug called RO7837195 in 224 people with moderate-to-severe ulcerative colitis who haven't gotten better with other treatments. Half will get the drug, half a placebo, to see if it can bring about remission by week 12. The goal is to find a new option for t…

This study tests a new drug called BI 3032950 in 80 adults with moderate to severe ulcerative colitis who haven't improved on other treatments. In the first part, the drug is given by IV every 4 weeks for 12 weeks. Those who respond then receive injections under the skin every 4 …

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can help children with mild to moderate ulcerative colitis. About 40 kids will take either the supplement or a placebo for 6 to 12 months, alongside their usual treatment. The main goa…

This study is testing whether robotic surgery is a safe and effective option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic surgery in 100 adults. The goal is to…

This study follows 200 adults in Japan with moderate to severe ulcerative colitis who are already prescribed risankizumab by their doctors. Researchers will track changes in disease activity over up to 156 weeks to see how well the drug works in real-world settings. The goal is t…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This study is testing vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV infusion for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This early-phase trial tests whether a patient's own immune cells, engineered to target BCMA and/or CD19, can calm severe ulcerative colitis that hasn't responded to other treatments. Twelve adults with moderate-to-severe active disease will receive a single infusion of these CAR…

This early-stage study is testing whether an oral probiotic called R-3750 is safe and tolerable for people with mild to moderate ulcerative colitis. About 36 adults will take the probiotic and be monitored for side effects, inflammation, and symptom changes. The goal is to see if…

This study is testing a minimally invasive weight loss procedure called endoscopic sleeve gastroplasty (ESG) in 12 people who have both obesity and ulcerative colitis and are planning or have had colon removal surgery. The procedure uses a suturing device to reduce stomach size b…

This study follows 400 adults with moderate to severe ulcerative colitis who are starting upadacitinib (RINVOQ) as part of their regular care. Researchers will track how well the drug controls symptoms like diarrhea and rectal bleeding over two years. The goal is to see if early …

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether a 12-week personalized aerobic exercise program, done at home with remote guidance, can improve heart and lung fitness, control disease activity, and boost quality of life in adults with inactive or mildly active inflammatory bowel disease (IBD). About 28…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous anti-TNF treatment stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and health ove…

This study tests an oral medication called etrasimod in 36 adolescents (ages 12 to under 18) with moderate to severe ulcerative colitis, a chronic bowel condition. The goal is to see if the drug can safely reduce inflammation and help achieve remission over 52 weeks, with an opti…

This study tests whether adding diet counseling and stress management to standard advanced therapy helps people with active Crohn's disease or ulcerative colitis achieve remission. About 160 adults will be split into four groups, each receiving different combinations of dietitian…

This study tests whether adding a new drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab alone for up to 104 we…

This early trial tests whether a device that sends mild electrical pulses to the sacral nerve can safely help control symptoms of ulcerative colitis. The study will enroll 15 adults whose disease has not responded well to standard medications. Researchers will track changes in di…

This Phase 2a study tests whether MK-8690 can help adults with moderate-to-severe ulcerative colitis achieve remission. About 100 participants will receive either the drug or a placebo injection. The main goal is to see if more people on MK-8690 have no or mild symptoms after 12 …

This study follows 80 Chinese adults with moderate to severe ulcerative colitis who are already prescribed upadacitinib by their doctor. Researchers will collect routine medical data over one year to see if the drug improves symptoms like bloody diarrhea. No extra tests or visits…

This Phase 3 study tests whether duvakitug, an injected drug, can help people with moderate to severe ulcerative colitis achieve remission and heal their gut lining. About 980 adults will receive either duvakitug or a placebo for up to 12 weeks. The goal is to see if the drug red…

This study tests a special form of vitamin B3 (nicotinamide) that releases in the lower gut to treat mild to moderate ulcerative colitis. About 459 adults will receive either a low or high dose of the vitamin or a placebo. The goal is to see if it can reduce symptoms and improve …

This study tests a daily pill called filgotinib in 80 children aged 8 to 17 with moderate to severe ulcerative colitis, a chronic gut disease. The goal is to see if the drug can reduce inflammation and help children feel better. All participants receive the drug, and the study tr…

This study is testing whether two types of fibre supplements—acacia gum and microcrystalline cellulose—can lower gut inflammation in people with ulcerative colitis. Sixty-nine participants will add one of the fibres or a placebo to their usual diet for six weeks. Researchers will…

This study tests a once-daily food supplement designed to improve gut bacteria in people with mild-to-moderate ulcerative colitis. About 162 adults will take either the supplement or a placebo for 24 weeks, alongside their usual treatment. The goal is to see if the supplement hel…

This study is for children with ulcerative colitis or Crohn's disease who already completed a previous vedolizumab trial. It aims to see how safe the drug is over a longer period. About 240 kids will receive vedolizumab infusions or be observed without treatment. Researchers will…

This phase 2 trial tests whether rupatadine, an allergy medicine, can help control inflammation in people with mild-to-moderate ulcerative colitis. About 60 adults will take rupatadine or a standard treatment (mesalamine) for several weeks. The goal is to see if rupatadine reduce…

This study tests whether butyrate enemas can help Hispanic children aged 7-21 with mild-to-moderate ulcerative colitis. Butyrate is a natural substance made by gut bacteria that may reduce inflammation. The goal is to see if it can lower disease activity scores and improve marker…

This study tests a new oral drug called BRS201 in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits for blood, stool, and urine tests. The goal is to see if BRS201…

This study tests whether adding a freeze-dried fecal transplant (LFMT) to standard biologic therapy (vedolizumab or ustekinumab) is safe and helps more people with ulcerative colitis reach remission. About 40 adults with active UC will receive either LFMT or a placebo alongside t…

This study tests a new drug called SAR442970 for people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. About 99 adults will receive either the drug or a placebo to see if it can help control the disease and reduce symptoms…

This program provides early access to upadacitinib for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis. It is for patients who have no other suitable treatments and cannot join a clinical trial. A doctor must decide if the potenti…

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study tests the drug risankizumab in children aged 2 to 18 with moderate to severe ulcerative colitis, a disease that causes inflammation and bleeding in the colon. The trial has three parts: first, all children receive the drug intravenously for 12 weeks; then, they are ran…

This study tests whether giving several fecal transplants (instead of just one) works better to clear repeat C. diff infections in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusions of healthy donor…

This study tests a daily medication called filgotinib (200 mg) in about 94 Korean adults with moderate-to-severe ulcerative colitis. The main goal is to see if it can bring the disease into remission (no active symptoms) by week 10 or 22. Participants take the pill once daily and…

This study tests whether combining two drugs, vedolizumab and tofacitinib, can help adults with moderate to severe ulcerative colitis achieve remission. Participants receive both drugs for 8 weeks, then those who respond continue on vedolizumab alone for 44 weeks. The goal is to …

This study tests whether adding fermented foods to the diet can reduce inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. About 21 adults with confirmed UC and active symptoms will eat fermented foods and be monitored for changes in a sto…

This study tests whether taking freeze-dried fecal transplant capsules (PRIM-DJ2727) can help adults with ulcerative colitis stay in remission and avoid flare-ups. About 58 participants will take the capsules or a placebo for 12 weeks alongside their usual treatment. The goal is …

This study is testing whether a remote monitoring app can help people with active inflammatory bowel disease (Crohn's or ulcerative colitis) spend more time in remission. About 290 adults whose disease is flaring will use the app to track symptoms and health data. The goal is to …

This study tests a new drug called eltrekibart, given alone or with another drug (mirikizumab), in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if the treatment can reduce symptoms and help the colon heal. Participants must have tried other treatments…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can stop symptoms like rectal bleeding and frequent stools, and…

This program provides children and teenagers with moderate to severe ulcerative colitis or Crohn's disease continued access to vedolizumab, a medication given through a vein, after they finish a related study. It is for those who still benefit from the treatment and have no good …

This study looks at how children and teenagers with moderate to severe ulcerative colitis or Crohn's disease process a drug called vedolizumab when given as a shot under the skin. About 70 participants who already responded to vedolizumab given through a vein will receive the sho…

This study looks at the long-term safety of a drug called vedolizumab given as a shot under the skin to children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who did well on the drug in an earlier study will keep getting it, while those who didn…

This study is testing an extended-release form of budesonide, a steroid, in children aged 5 to 17 with mild to moderate ulcerative colitis. The goal is to see if the drug can safely help kids achieve remission, meaning less bleeding and more normal bowel habits. Participants will…

This study tests an investigational drug called duvakitug in people with moderate-to-severe ulcerative colitis who have already responded to treatment. The goal is to see if duvakitug can help maintain remission better than a placebo over 40 weeks, with an optional long-term exte…

This study tests whether long-acting antibodies can help people with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. About 645 adults will receive the antibodies through an IV infusion followed by regular shots under the skin. The goal is to reduce gu…

This study tests whether a diet rich in anti-inflammatory American foods (like grilled meats, salmon, oatmeal, and avocado) can help control ulcerative colitis and lead to disease remission. About 122 American adults with mild to moderate UC will follow the diet, and researchers …

This study tests a new drug called ISM5411 in 80 adults with active ulcerative colitis. The goal is to see if it is safe and helps control the disease. Participants will receive either the drug or a placebo, and researchers will monitor side effects and how well the drug works.

This study looks at whether taking prebiotics (a type of fiber) can improve gut health and reduce symptoms in people with ulcerative colitis, a form of inflammatory bowel disease. About 70 adults with active symptoms will take prebiotics for 8 weeks. Researchers will track change…

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study tests an experimental drug called tilpisertib fosmecarbil (GS-5290) in 176 adults with moderate to severe ulcerative colitis. Participants will receive either the drug or a placebo for 12 weeks to see if it improves symptoms like diarrhea, bleeding, and bowel inflammat…

This study tests whether swallowing frozen capsules containing filtered or whole donor stool can safely bring ulcerative colitis into remission. About 129 adults with mild-to-moderate active disease who have not responded to standard treatments will take the capsules or a placebo…

This study looks at how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and teenagers with moderate-to-severe ulcerative colitis or Crohn's disease. About 150 participants who have already been in earlier studies will continue treatme…

This study follows about 200 adults with moderate to severe ulcerative colitis who are prescribed risankizumab by their doctors. Researchers will track how well the drug controls symptoms like bleeding and diarrhea over 52 weeks. The goal is to see how effective and safe the trea…

This study is for adults with moderate to severe Crohn's disease or ulcerative colitis who have already responded to the study drug zasocitinib (TAK-279) in a previous trial. The main goal is to check the long-term safety of this oral medication over up to 3 years. Researchers wi…

This study tests whether changing sleep timing and using morning light therapy can improve symptoms and quality of life in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 68 adults with active IBD symptoms will participate. Re…

This study is testing whether adding the allergy drug desloratadine to standard treatment (mesalamine) can reduce inflammation and improve symptoms in people with mild to moderate ulcerative colitis. About 44 adults aged 18 to 65 with active disease are being recruited. The goal …

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study tests if pentoxifylline, a drug already used for other conditions, can safely reduce symptoms of mild to moderate ulcerative colitis. About 60 adults will take the drug and be monitored for changes in bowel symptoms and quality of life. The goal is to see if this offer…

This study tests a small device placed under the skin near the tailbone that sends mild signals to a nerve, aiming to reduce sudden bowel urgency in people with ulcerative colitis. About 137 adults with the condition will take part. The device is implanted in a same-day procedure…

This study tests whether a special 5-day diet that mimics fasting can lower inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptom changes. The goal is to see …

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This study uses health insurance claims data from Korea to count how many children under 18 have Crohn's disease or ulcerative colitis, and how their treatment changes as they grow. Researchers will look at patterns of medication use, hospital visits, and costs over several years…

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy and after childbirth, as well as pregnancy outcomes and treatments needed. The goal is to better understand…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) and children with other gut disorders. Researchers will use a technique called spatial transcriptomics to see which genes are active in different parts of the gut. The goa…

This study aims to identify biological markers that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will collect blood and tissue samples from 100 adults, including healthy controls and I…

This study is collecting health information and samples from 100 people with inflammatory bowel disease (IBD) when they change treatments. Researchers will use artificial intelligence to analyze this data and find patterns that could predict when a treatment change is needed. The…

This study is testing whether a blood test measuring a protein called LRG can tell if the gut lining has healed in people with ulcerative colitis. Researchers will compare blood LRG levels with colonoscopy and tissue samples in 100 patients. If the blood test works, it could offe…

This study surveys 400 adults with inflammatory bowel disease (IBD) from two medical centers to understand how social factors like insurance, income, and support affect medication adherence and quality of life. Researchers focus on Hispanic and Black patients, who often have wors…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers will look for T cells that are active in inflamed tissues to find their targets. The goal is to discover new targets for future …

This study looks at whether changes in sleep can warn of a flare-up in people with inflammatory bowel diseases like Crohn's disease or ulcerative colitis. Researchers will track sleep patterns and disease activity in 216 adults who are currently in remission. The goal is to see i…

This study aims to find out why some people with inflammatory bowel disease (IBD) develop long-term belly pain, even when their disease is quiet. Researchers will follow thousands of patients over time, collecting questionnaires, blood and stool samples, and heart rate data. The …

This study follows 450 adults who have been diagnosed with inflammatory bowel disease (IBD) during a routine colonoscopy but have no symptoms yet. Researchers will track them over time to see how the disease progresses, including when symptoms like diarrhea or abdominal pain begi…

This study follows about 1,182 pregnant women with ulcerative colitis who are taking or have taken ozanimod. Researchers will watch for any health problems in the mothers and their babies, such as birth defects or pregnancy complications. The goal is to learn whether the drug is …

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study is for adults in South Korea with ulcerative colitis or Crohn's disease who are already taking vedolizumab injections. Researchers will look at medical records to track side effects and how well the treatment works. No new medicine or treatment is given—this is just an…

This study looks at whether ultrasound can detect scarring (fibrosis) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from 50 adults undergoing routine colonoscopy. The goal is to develop better ways to measure disease …

This study observes how doctors use a treat-to-target strategy for people with Crohn's disease or ulcerative colitis in routine care. Researchers will review medical records of 2000 adults over 24 months to see if adjusting treatment based on disease activity improves outcomes. N…

This study watches how body composition (muscle and fat) changes in 48 adults with inflammatory bowel disease (Crohn's or colitis) who start a new medication. Researchers use a simple, painless test called bioelectrical impedance to measure these changes over a year. The goal is …

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…