Could vitamin B3 tame gut inflammation?
NCT ID NCT06488625
First seen Jun 01, 2026 · Last updated Jun 20, 2026 · Updated 5 times
Summary
This study tests a special form of vitamin B3 (nicotinamide) that releases in the lower gut to treat mild to moderate ulcerative colitis. About 459 adults will receive either a low or high dose of the vitamin or a placebo. The goal is to see if it can reduce symptoms and improve gut health without serious side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Agaplesion Frankfurter Diakonie Kliniken gGmbH
RECRUITINGFrankfurt am Main, 60431, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Charite Universitaetsmedizin Berlin KöR
RECRUITINGBerlin, 10117, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Charite Universitaetsmedizin Berlin KöR
RECRUITINGBerlin, 12203, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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DRK Kliniken Berlin
RECRUITINGBerlin, 12559, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Evangelisches Krankenhaus Kalk gGmbH
RECRUITINGCologne, 51103, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gastroenterologie am Herrengarten
RECRUITINGDarmstadt, 64293, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gastroenterologische Schwerpunktpraxis Prof. Dr. Ludwig & Dr. med. Güthle
RECRUITINGDornstadt, 89160, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gastropraxis Magdeburg
RECRUITINGMagdeburg, 39104, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gastropraxis an der St. Barbara-Klinik
RECRUITINGHamm, 59073, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gesundheit Nord gGmbH Klinikverbund Bremen
RECRUITINGBremen, 28205, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Goethe University Frankfurt
RECRUITINGFrankfurt, 60590, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Martin-Luther-Universitaet Halle-Wittenberg
RECRUITINGHalle, 06120, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medical Care Unit Dachau
WITHDRAWNDachau, 85221, Germany
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Practice for Gastroenterology
RECRUITINGHanover, 30449, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Private Practice for Gastroenterology
RECRUITINGHeidelberg, 69115, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sozialstiftung Bamberg
RECRUITINGBamberg, 96049, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Marien Und St. Annastiftskrankenhaus
RECRUITINGLudwigshafen, 67067, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaet Muenster
NOT_YET_RECRUITINGMünster, 48149, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaetsklinikum Aachen AöR
NOT_YET_RECRUITINGAachen, 52074, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaetsklinikum Augsburg
RECRUITINGAugsburg, 86156, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
RECRUITINGDresden, 01307, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaetsklinikum Schleswig-Holstein AöR
RECRUITINGKiel, Schleswig-Holstein, 24105, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaetsklinikum Schleswig-Holstein AöR
RECRUITINGLübeck, 23538, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaetsklinikum Ulm AöR
RECRUITINGUlm, 89081, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitat Heidelberg
RECRUITINGMannheim, 68167, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Medical Center Hamburg-Eppendorf
NOT_YET_RECRUITINGHamburg, 20246, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nicotinamide (vitamin B3) in a special capsule that releases it in the lower gut
What this could lead to
If it works, this could offer a new, well-tolerated treatment option for people with mild to moderate ulcerative colitis.
What could go wrong
This is an early-to-mid stage trial, so the treatment may not prove effective or safe. Results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.