Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New hope for ulcerative colitis patients who failed other treatments

NCT ID NCT06979336

Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 4 times

Summary

This study tests a new drug called RO7837195 for people with moderate to severe ulcerative colitis who haven't gotten better with other treatments. About 224 participants will receive either the drug or a placebo for 12 weeks to see if it can bring about remission. The goal is to find a new option for those who need it most.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
RO7837195
What this could lead to
If successful, this could provide a new treatment option for people with ulcerative colitis who haven't responded to other therapies.
What could go wrong
This is an early phase 2 trial with only 224 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 224 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of ulcerative colitis (UC) established at least 3 months * Moderately to severely active UC assessed by mMS * Inadequate response, loss of response, or intolerance to conventional or advanced therapies for UC Exclusion Criteria: * Prior extensive colonic resection, subtotal or total colectomy, or planned surgery for UC * Diagnosis of Crohn's disease or indeterminate colitis * Treatment with an advanced therapy targeted at tumor necrosis factor-like cytokine 1A (TL1a) * Inadequate response, loss of response, or intolerance to treatment of UC with an advanced therapy targeted at IL-12 and/or IL-23

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Ulcerative colitis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ulcerative colitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    103 sites in 15 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ASST Rhodense, Rho Memorial Hospital

    RECRUITING

    Rho, Lombardy, 20017, Italy

  • Addenbrook'es Hospital

    RECRUITING

    Cambridge, CB2 0QQ, United Kingdom

  • Allmedica Badania Kliniczne sp. z o.o. sp.k.

    RECRUITING

    Nowy Targ, 34-400, Poland

  • Asan Medical Center.

    RECRUITING

    Seoul, 05505, South Korea

  • Asian Institute of Gastroenterology

    RECRUITING

    Hyderabad, Andhra Pradesh, 500032, India

  • Associao Paranaense de Cultura APC

    RECRUITING

    Curitiba, Paraná, 80230-130, Brazil

  • BR Trials - Ensaios Clnicos e Consultoria

    RECRUITING

    São Paulo, São Paulo, 05003-090, Brazil

  • Binzhou Medical university hospital

    RECRUITING

    Binzhou, Shandong, 256603, China

  • CECIP - Centro de Estudos Clínicos do Interior Paulista

    RECRUITING

    Ja, São Paulo, 17201-130, Brazil

  • CHU Clermont Ferrand - Hôpital d'Estaing

    RECRUITING

    Clermont-Ferrand, Puy De Dome, 63000, France

  • CHU Saint Etienne - Hpital Nord

    RECRUITING

    Saint-Étienne-de-Montluc, Pays de la Loire Region, 42055, France

  • CPQuali Pesquisa Clinica Ltda

    RECRUITING

    So Paulo, São Paulo, 01228-000, Brazil

  • Centre hospitalier Lyon Sud

    RECRUITING

    Pierre-Bénite, Rhone, 69495, France

  • Centro Digestivo de Curitiba

    RECRUITING

    Curitiba, Paraná, 80430-160, Brazil

  • Centro Medico Clinico Quirurgico Especializado en Investigacion

    RECRUITING

    Tlajomulco de Zúñiga, Jalisco, 45645, Mexico

  • Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan

    RECRUITING

    Mérida, Yucatán, 97130, Mexico

  • Centrum Medyczne "Medis"

    RECRUITING

    Bydgoszcz, 85-229, Poland

  • Centrum Medyczne Lukamed Joanna Luka

    RECRUITING

    Chojnice, 89-600, Poland

  • Centrum Zdrowia MDM

    WITHDRAWN

    Warsaw, 00-189, Poland

  • Chosun University Hospital

    RECRUITING

    Gwangju, 61453, South Korea

  • Chronos Pesquisa Clinica

    RECRUITING

    Brasília, Federal District, 72145-450, Brazil

  • Chung-Ang University Hospital

    RECRUITING

    Seoul, 06973, South Korea

  • Clinical Research Center Spka z ograniczon odpowiedzialnoci Medic-R Sp.k.

    RECRUITING

    Poznan, 61-731, Poland

  • Clinical Research of Osceola, LLC

    RECRUITING

    Kissimmee, Florida, 34741, United States

  • Clinique IMD

    RECRUITING

    Montreal, Quebec, H3H 1E8, Canada

  • Clinsante S.C. Osrodek Badan Klinicznych

    RECRUITING

    Bydgoszcz, 85-794, Poland

  • ETG Zamosc

    RECRUITING

    Zamość, 22-400, Poland

  • FAICIC S de R.L. de C.V

    RECRUITING

    Veracruz, 91900, Mexico

  • Fiona Stanley Hospital

    RECRUITING

    Murdoch, Western Australia, 6150, Australia

  • Fondazione Poliambulanza Istituto Ospedaliero

    RECRUITING

    Brescia, Lombardy, 25124, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    RECRUITING

    Rome, Emilia-Romagna, 00168, Italy

  • Fukuoka University Hospital

    RECRUITING

    Fukuoka, Fukuoka, 814-0180, Japan

  • Gastro Care Institute

    RECRUITING

    Lancaster, California, 93534, United States

  • Groupe Hospitalier Ambroise Pare - Institut des MICI

    RECRUITING

    Neuilly, Hauts De Seine, 92200, France

  • Guy's Hospital

    RECRUITING

    London, Greater London, SE1 9RT, United Kingdom

  • HUWC - UFC - Hospital Universitrio Walter Cantdio - Universidade Federal do Cear

    RECRUITING

    Fortaleza, Ceará, 60430-370, Brazil

  • Hopital Maisonneuve-Rosemont d/b/a CIUSSS de l'Est-de-l'le-de-Montral

    RECRUITING

    Montreal, Quebec, H1T 2M4, Canada

  • Hospital Ernesto Dornelles

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90160-093, Brazil

  • Hospital Felicio Rocho

    RECRUITING

    Belo Horizonte, Minas Gerais, 30110-934, Brazil

  • Hospital Gloria DOr - Hospitais Integrados da Gavea S/A

    RECRUITING

    Rio de Janeiro, 22211-230, Brazil

  • Hospital de Clnicas de Porto Alegre

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Huizhou Municipal Central Hospital

    RECRUITING

    Huizhou, Guangdong, 516001, China

  • I.R.C.C.S Policlinico San Donato

    RECRUITING

    San Donato Milanese (MI), Lombardy, 20097, Italy

  • Inje university Haeundae Paik Hospital

    RECRUITING

    Busan, 48108, South Korea

  • Institute of Post Graduate Medical Education And Research

    RECRUITING

    Kolkata, West Bengal, 700020, India

  • Instituto de Assistencia Medica ao Servidor Publico Estudo Estadual

    RECRUITING

    São Paulo, São Paulo, 04039-004, Brazil

  • Intercity Gastroenterology

    RECRUITING

    Fresh Meadows, New York, 11366, United States

  • Istituto Clinico Humanitas

    RECRUITING

    Rozzano, Lombardy, 20089, Italy

  • John Radcliffe Hospital

    RECRUITING

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

  • Kaiser Clinica

    RECRUITING

    São José do Rio Preto, São Paulo, 15015-110, Brazil

  • Kangbuk Samsung Hospital

    RECRUITING

    Seoul, 03181, South Korea

  • King's College Hospital

    RECRUITING

    London, Greater London, SE5 9RS, United Kingdom

  • Kingsway Hospital

    RECRUITING

    Nagpur, Maharashtra, 440010, India

  • Kojunkai Daido Clinic

    RECRUITING

    Nagoya, 457-8511, Japan

  • Kokikai Tsujinaka Hospital Kashiwanoha

    RECRUITING

    Kashiwa-shi, Chiba, 277-0871, Japan

  • L2IP ?Instituto de Pesquisas Clínicas Ltda.

    RECRUITING

    Brasília, Federal District, 70200-730, Brazil

  • London Digestive Disease Institute

    RECRUITING

    London, Ontario, N6K 1M6, Canada

  • MZ Badania Slowik Zymla Sp.j.

    RECRUITING

    Knurów, 44-190, Poland

  • Mater Misericordiae Limited

    RECRUITING

    South Brisbane, Queensland, 4101, Australia

  • Medical Associates Research Group, Inc.

    RECRUITING

    San Diego, California, 92123, United States

  • Medical Network Spka z o. o., WIP Warsaw IBD Point Profesor Kierkus

    RECRUITING

    Warsaw, 04-501, Poland

  • Medon Clinical Research sp. z o.o

    RECRUITING

    Warsaw, 02-679, Poland

  • Monroe Biomedical Research

    RECRUITING

    Monroe, North Carolina, 28112, United States

  • NHO Fukuyama Medical Center

    RECRUITING

    Fukuyama-shi, Hiroshima, 720-8520, Japan

  • NHO Kanazawa Medical Center

    RECRUITING

    Kanazawa, Ishikawa-ken, 920-8650, Japan

  • NHO Osaka National Hospital

    RECRUITING

    Osaka, Osaka, 540-0006, Japan

  • NSZOZ Termedica Centrum Badan Klinicznych

    RECRUITING

    Poznan, 60-681, Poland

  • Nemocnice Slany

    RECRUITING

    Slaný, 27401, Czechia

  • Newdata Clinical Trials

    RECRUITING

    Aracaju, Sergipe, 49075-000, Brazil

  • Ospedale Mauriziano Umberto I

    RECRUITING

    Turin, Piedmont, 10128, Italy

  • Ospedale Sacro Cuore Don Calabria

    RECRUITING

    Negrar, Veneto, 37024, Italy

  • Ospedale San Raffaele

    RECRUITING

    Milan, Lombardy, 20132, Italy

  • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych Administracji

    RECRUITING

    Warsaw, 02-507, Poland

  • Peak Gastroenterology Associates

    RECRUITING

    Colorado Springs, Colorado, 80907, United States

  • Pesquisare Saude

    RECRUITING

    Santo André, São Paulo, 09080-110, Brazil

  • PreventaMed, s.r.o.

    RECRUITING

    Olomouc, 779 00, Czechia

  • Provita Poliklinika sp. z o.o

    WITHDRAWN

    Warsaw, 02-647, Poland

  • Przychodnia VISTAMED

    RECRUITING

    Wroc?aw, 53-149, Poland

  • Renmin Hospital of Wuhan University

    RECRUITING

    Wuhan, Hubei, 430060, China

  • Royal Liverpool University Hospital

    RECRUITING

    Liverpool, Merseyside, L7 8YE, United Kingdom

  • Royal Melbourne Hospital

    RECRUITING

    Parkville VIC, Victoria, 3050, Australia

  • S. R. Kalla Memorial Gastro & General Hospital

    RECRUITING

    Jaipur, Rajasthan, 302001J, India

  • SOLUMED Centrum Medyczne

    RECRUITING

    Poznan, 60-529, Poland

  • Saga University Hospital

    RECRUITING

    Saga, Saga-ken, 849-8501, Japan

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Shinseikai Sai Gastroenterology, Proctology

    RECRUITING

    Fujidera-shi, 583-0027, Japan

  • Shree Giriraj Multispeciality Hospital

    RECRUITING

    Rajkot, Gujarat, 360005, India

  • Sichuan Provincial People's Hospital

    RECRUITING

    Chengdu, Sichuan, 610072, China

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    RECRUITING

    Hangzhou, 310018, China

  • Takamatsu Red Cross Hospital

    RECRUITING

    Takamatsu, Kagawa-ken, 760-0017, Japan

  • The Catholic University of Korea Daejeon ST. Mary?s Hospital

    RECRUITING

    Daejeon, 34943, South Korea

  • The Catholic University of Korea Eunpyeong St. Mary's Hospital

    RECRUITING

    Seoul, 03312, South Korea

  • The First Affiliated Hospital Of Fujian Medical University

    RECRUITING

    Fuzhou, Fujian, 350005, China

  • The First Affiliated Hospital of Ningbo University

    RECRUITING

    Ningbo, Zhejiang, 315010, China

  • The First Hospital of Jilin University

    RECRUITING

    Changchun, Jilin, 130021, China

  • The Second Affiliated Hospital of Zhengzhou University

    RECRUITING

    Zhengzhou, Henan, 450014, China

  • The second Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, Guangdong, 510260, China

  • The sixth affiliated hospital of Sun Yat-Sen University

    RECRUITING

    Guangzhou, Guangdong, 510655, China

  • Twoja Przychodnia-Szczecinskie Centrum Medyczne

    RECRUITING

    Szczecin, 71-434, Poland

  • Universitaetsklinikum Frankfurt Goethe-Universitaet

    RECRUITING

    Frankfurt am Main, Hesse, 60590, Germany

  • University of Chicago Medical Center

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Utah Hospitals & Clinics

    RECRUITING

    Salt Lake City, Utah, 84132, United States

  • Velocity Skierniewice Sp. z o.o

    WITHDRAWN

    Skierniewice, 96-100, Poland

  • Vita Longa Sp. z o.o.

    RECRUITING

    Katowice, 40-748, Poland

  • Yonsei University Wonju Severance Christian Hospital

    RECRUITING

    Wŏnju, Gangwon-do, 26426, South Korea

  • Zhongshan Hospital Xiamen University

    RECRUITING

    Xiamen, Fujian, 361004, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.