ULCERATIVE COLITIS

This study tests whether adding acupuncture to the standard drug mesalazine helps people with mild-to-moderate ulcerative colitis achieve and stay in remission. Eighty adults will receive either real acupuncture or sham patches alongside mesalazine for 12 weeks. The goal is to se…

This study follows 40 children with Crohn's disease or ulcerative colitis who developed severe psoriasis from anti-TNF drugs and switched to ustekinumab. Researchers will check if their gut disease stays under control 3 to 6 months after the switch. The goal is to see if ustekinu…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, ulcerative colitis, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improv…

This study tests a special diet designed to meet the protein needs of people with ulcerative colitis while reducing harmful gas produced by gut bacteria. Researchers will measure changes in stool samples from 40 adults with mild to moderate disease. The goal is to see if this die…

This study tests an experimental drug called ATH-063 in 120 adults with moderate-to-severe ulcerative colitis who have not improved with biologic therapies. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding and improve colon healing over 12 weeks. Part…

This study tests a steroid foam (budesonide) given rectally to children aged 5 to 17 with mild to moderate distal ulcerative colitis. The goal is to see if it can safely induce remission by reducing inflammation, bleeding, and stool frequency. About 100 children will receive eith…

This study observes 35 adults with moderate-to-severe Crohn's disease or ulcerative colitis to see how long they continue taking guselkumab in everyday medical practice. Researchers will track treatment persistence and early symptom relief, like reduced bowel urgency. No experime…

This study tests a blood-filtering device called Efferon LPS in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone …

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This pilot study will test a 24-week digital self-management program designed to help people with inflammatory bowel disease (IBD) manage their symptoms and improve their quality of life. The program is accessed via web or mobile device and includes modules to build long-term hab…

This study tests whether a 5-week heart rate variability biofeedback program (a guided breathing technique) can reduce symptoms like belly pain and bloating in 23 adults with active ulcerative colitis but no active gut inflammation. Participants will be followed for 17 weeks. The…

This study compares two sedatives—remimazolam and midazolam—for colonoscopy in 200 adults with inflammatory bowel disease (Crohn's or ulcerative colitis). The goal is to see if remimazolam provides equal or better patient satisfaction and allows faster recovery. Participants rece…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study tests whether watching a short video tailored to their specific type of inflammatory bowel disease (IBD) helps patients better prepare their bowel for a colonoscopy. About 600 adults with ulcerative colitis or Crohn's disease will be randomly assigned to receive either…

This study looks at children with ulcerative colitis (UC) to see if changes in bile acids in the gut make them more likely to get a serious C. difficile infection. Researchers will compare bile acid and gut bacteria patterns in 80 children: those with active UC (with or without C…

This study looks at how anxiety, depression, and stress might cause advanced IBD treatments to stop working. Researchers will ask 450 people with IBD to fill out questionnaires about their mental health while they receive regular infusions. The goal is to understand if mental hea…

This study will follow 100 adults with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, for 3 years. Researchers will collect blood, stool, and tissue samples, along with imaging and diet information, to better understand how genetics and immune…

This study will use musculoskeletal ultrasound to look for hidden joint, muscle, and tendon inflammation in 81 people with inflammatory bowel disease (IBD) who have no known arthritis. The goal is to see how common these hidden problems are and to develop a standard ultrasound ch…

This study looks at whether measuring belly fat with CT scans can help predict how well biologic therapy works in people with ulcerative colitis. Researchers will track changes in fat volume over 6 months in 200 adults. The goal is to find a better way to match patients with effe…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

This study looks at whether a simple intestinal ultrasound can accurately measure disease activity in people with active ulcerative colitis, compared to the standard colonoscopy. Researchers will enroll 200 adults with active UC to see if the ultrasound scores match the colonosco…

This study follows 50 adults with ulcerative colitis who are already seeing a naturopathic doctor. Over 12 weeks, researchers track symptom changes using questionnaires. The goal is to gather early information on how naturopathic care may help, without changing anyone's usual tre…