ENDOMETRIOSIS

This study is testing a new robotic surgery system (Medtronic Hugo™) for hysterectomy, a surgery to remove the uterus. It includes 70 adult patients with conditions like fibroids, endometriosis, or certain cancers. The goal is to see if the robot can perform the surgery safely an…

This study tests whether the da Vinci Xi robot can safely perform various surgeries in children and teens aged 6 to 21. The procedures include gallbladder removal, weight-loss surgery, and lung repairs. The goal is to see if robotic surgery works as well as traditional open surge…

This study looks at whether a medication called goserelin acetate, which temporarily stops menstruation (like a short-term menopause), can reduce fat buildup in the liver of women with endometriosis. The researchers will measure liver fat and stiffness using ultrasound in 62 wome…

This study looks at whether having surgery to remove deep endometriosis in the bowel before IVF helps women with infertility get pregnant. About 120 women will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see how many achieve a clinical pregna…

This study tests whether a new capsule (Indinol Forto) works as well as a standard tablet (Visanne) for reducing pelvic pain caused by endometriosis. About 290 women aged 18 to 45 who have been diagnosed with endometriosis through surgery will take one of the two medications for …

This study tests if drinking a special nutritional supplement before bladder removal surgery can lower the risk of infections and other complications. About 232 adults having this surgery will be randomly assigned to receive the supplement or standard care. The main goal is to se…

This study tests whether a gentler surgical technique using argon plasma can better protect the ovaries compared to the standard cystectomy for ovarian endometriomas. Seventy-two women with endometriosis will be randomly assigned to one of the two procedures. The main goal is to …

This study is for women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. It compares two approaches: having surgery to remove endometriosis tissue before trying IVF, or going straight to IVF without surgery. The goal is to see which method leads to mo…

This study aims to find markers in menstrual blood that can help diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at samples before and after surgery. The goal i…

This study is testing a special PET/MRI scan to see if it can accurately diagnose endometriosis in women with symptoms. About 24 women will get the scan before their planned surgery. The goal is to find a less invasive way to detect this painful condition.

This study looks at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition that causes chronic pelvic pain and heavy periods. Researchers will measure L-PGDS in blood, urine, and tissue samples from 60 women with and without adenomyosis. If successful, t…

This study is testing a new, non-invasive lab test that uses menstrual blood to diagnose endometriosis. Currently, diagnosis requires surgery, which can take years to get. The study will enroll 200 women aged 14-49 to see how accurate the test is compared to standard methods.

This study is testing a blood test called HerResolve™ to see if it can accurately detect endometriosis in women aged 18 to 49 who have symptoms like pelvic pain or abnormal bleeding. The test results will be compared to findings from a standard diagnostic laparoscopy (a surgical …

This study tests whether a special PET scan (18F-FES) can find endometriosis lesions more accurately than MRI. It will involve 20 women having surgery for endometriosis, some with high pain and some with low pain. The scan measures estrogen receptor activity, which may help docto…

This study looks at whether changing what you eat and taking probiotics can help reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome (IBS). About 74 women aged 18 to 50 will be randomly assigned to one of three groups to test the effects. …

This study tests whether giving a GnRH agonist hormone injection before a frozen embryo transfer can improve pregnancy rates in women with endometriosis or adenomyosis. About 180 women aged 18-36 will be randomly assigned to receive either the hormone plus standard estrogen/proge…

This study compares two types of minimally invasive surgery—robot-assisted and standard laparoscopic—for removing the uterus in people with deep endometriosis and adenomyosis. The goal is to see which approach leads to fewer complications during and after surgery. About 224 adult…

This study looks at whether a non-surgical treatment called High-Intensity Focused Ultrasound (HIFU) provides lasting relief for people with rectal endometriosis. Researchers will compare quality-of-life scores before treatment and years later. About 140 participants who previous…

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in women with endometriosis. About 190 women aged 18 to 44 with moderate to severe pain will receive either the drug or a placebo for four months. The goal is to find a better treatment option for…

This study tests whether a low-FODMAP diet can reduce pain and improve quality of life in 150 women with endometriosis who also have gut symptoms like bloating and constipation. Participants will either follow the diet or continue their usual care. The goal is to see if changing …

This study tests a TENS device, which uses mild electrical pulses, to reduce pelvic pain in women with endometriosis or adenomyosis. About 92 women on stable hormone therapy will use the device daily for 4 weeks and rate their pain. The goal is to see if the device provides meani…

This study tests a non-invasive device that stimulates the vagus nerve through the ear to reduce chronic pelvic pain caused by endometriosis. About 72 women with endometriosis-related pain will use the device and report their symptom changes. The goal is to see if this gentle sti…

This study looks at whether practicing yoga can reduce pain in women with endometriosis. About 30 women aged 18 to 45 who have moderate pain and a confirmed diagnosis will take part. They will do yoga sessions and report their pain levels using questionnaires. The goal is to see …

This study tests a physiotherapy program that combines gentle exercise with pain education for women with endometriosis. 62 women will be split into two groups: one gets the full program, the other gets only pain education. Researchers will check pain, movement, quality of life, …

This study looks at whether combining pain education with therapeutic exercise can reduce pain and improve quality of life in women with endometriosis. Researchers will track how well participants stick with the program and measure changes in pain, negative thoughts about pain, a…

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 participants will either follow the special diet or their usual diet for 12 weeks. The goal is to see if changing what you eat can ease pelvic pain, pain during sex, and period…

This study tests an 8-week group program called PEEPS for women aged 18-48 with endometriosis-related chronic pelvic pain. Participants join weekly sessions with others and get usual care, while a comparison group receives only education. The goal is to see if the group support r…

This study tests whether doing yoga online (Tele-Yoga) can reduce chronic pelvic pain, fatigue, and improve quality of life in women with endometriosis. About 66 women will be randomly assigned to either a Tele-Yoga group or a control group. Researchers will measure pain, fatigue…

This study tests whether metformin, a common diabetes drug, can reduce pelvic pain in young women with endometriosis. Fourteen participants will take either metformin or a placebo daily for 6 months and track their symptoms. The goal is to see if this non-hormonal approach offers…

This study tests if brief whole-body exposure to extreme cold (around -120°C) can safely reduce pain and improve quality of life for people with endometriosis. Up to 30 participants will attend five 3-minute cryotherapy sessions over four weeks. Researchers will measure pain chan…

This study tests whether a low-fat plant-based diet can reduce pain and improve quality of life in women with endometriosis. Over 12 weeks, 120 participants will either follow the diet or stick with their usual eating habits. Researchers will measure changes in pain, inflammation…

This study compares a new surgical technique (IDLnR) to standard laparoscopic surgery for women with bowel endometriosis. The goal is to see if the new method improves bowel function and quality of life more than the standard approach. About 192 women aged 18-55 with confirmed bo…

This study compares a home pelvic floor physical therapy program to standard care for 30 women having endometriosis surgery (without hysterectomy). The goal is to see if the home program improves pelvic pain and quality of life during recovery. Participants will complete surveys …

This study tests whether listening to an educational podcast series can improve quality of life, reduce stigma, and increase satisfaction for people with chronic pelvic pain or endometriosis. About 100 adults will be randomly assigned to either standard care alone or standard car…

This study tests if a head-worn device that gently stimulates the brain can reduce chronic pelvic pain and improve mood and sleep in women with endometriosis. About 120 women will use the NettleEndo device at home for 20 minutes a day, five times a week for 12 weeks. Half will ge…

This study tests whether using a dye to see the ureters during deep endometriosis surgery causes less pain after the operation than the usual plastic stents. About 70 women aged 18-50 will take part. The goal is to see if this approach is practical and acceptable before a larger …

This small pilot study tests an internet-based therapy (Acceptance and Commitment Therapy) for 10 people with endometriosis and chronic pain. Participants learn skills like mindfulness and acceptance to reduce pain's impact on daily life. The goal is to see if this approach helps…

This study compares two types of radiation therapy—proton therapy and standard IMRT—given after surgery for endometrial or cervical cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 participants will fill out quality-of-life questionnaires to…

This study tests whether a smartphone app called Lyv Endo can improve quality of life and reduce symptoms for women with endometriosis. The app is used alongside standard medical care to help patients better manage their condition. Researchers will enroll 410 women with confirmed…

This study tests whether a program of workshops and nurse phone calls can improve quality of life for women with endometriosis. About 260 women with confirmed endometriosis and chronic pelvic pain will take part. The program includes sessions with different health experts and reg…

This study tests whether a single mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Researcher…

This study tests whether a special 'good pain consultation' that includes education about pain from a biopsychosocial perspective can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive this consu…

This study tests a custom, hemp-derived CBD product against a placebo to see if it can reduce pain and improve quality of life in people with endometriosis. Researchers will track pain levels and other symptoms over 12 weeks. The goal is to provide much-needed evidence on whether…

This study follows 15,000 women with endometriosis for up to 10 years to see how well different medical and surgical treatments work. Researchers will track pain, quality of life, disease return, and pregnancy rates. The goal is to learn which approaches help most over the long t…

This study looks at a new surgical tool called CUSA Clarity that uses ultrasound to gently remove endometriosis cysts from the ovary. The goal is to see if it can take out only the diseased tissue while leaving healthy ovary tissue untouched. Ten women will have their cyst walls …

This study aims to collect detailed information from 1000 people in the UK with endometriosis to help doctors diagnose and treat the condition more effectively. Participants will use a mobile app to track symptoms, provide biological samples, and wear a smartwatch to monitor slee…

This study looks at why some women develop endometriosis, a painful condition affecting 1 in 10 women. Researchers will measure body distances and hormone levels in 40 women with and without the disease. The goal is to find early signs that could lead to better understanding and …

This study aims to see if brain imaging can predict which women with severe endometriosis will have less pain after surgery. Researchers will scan the brains of 100 women before their operation and check their pain levels a year later. The goal is to better understand why some wo…

This study listens to 150 people with endometriosis across Europe to understand how they manage their condition day-to-day. Through diaries, interviews, and group discussions, researchers want to learn what makes people feel empowered or abandoned. The goal is to improve support …

This study follows 650 women with endometriosis who want to have a baby after diagnosis. Researchers compare pregnancy rates and live births between those who had medical treatment versus surgery. The goal is to understand which approach leads to better fertility outcomes.

This study looks at how surgery for severe deep endometriosis affects a woman's ovarian reserve (egg supply). Researchers will measure a hormone called AMH before and 12 months after surgery in 100 women aged 18-39. The goal is to see if the surgery reduces ovarian reserve, which…

This study is following 5,300 women to learn if endometriosis and adenomyosis get worse over time. Researchers will track pain, bleeding, and fertility, and also study the immune system and gut bacteria. The goal is to better understand these conditions, not to test a new treatme…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. 140 healt…

This study is looking at whether a simple, noninvasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare eye images from 100 women with and without the condition. The goal is to learn more about how endometriosis affects the body, not…

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or symptoms like pelvic pain. Researchers want to see if the emergency visit leads to proper follow-up care, such as specialist appointments or imaging. The goal is to understand…

This study is building a national database to track how well two treatments—surgery and a freezing technique called cryoablation—work for parietal endometriosis (endometriosis in the abdominal wall). Researchers will follow 300 adults with symptomatic nodules to compare outcomes …

This study aims to see if measuring how much pelvic organs move during an MRI can help doctors better diagnose endometriosis and understand why some treatments don't work. Researchers will compare MRI scans taken at rest and while pushing to measure organ movement in 52 women wit…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study aims to create a realistic model of the endometrium (the lining of the uterus) using tissue from 90 women with and without endometriosis. The goal is to test how well different hormone treatments work on each person's tissue, so doctors can choose the best therapy with…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their healthcare team. Twenty pre-menopausal women aged 18 and older with known or suspected endometriosis will use the app for 6 months,…

This study looks at how different ovarian stimulation protocols affect blood clotting and breakdown in women with infertility. Researchers will compare changes in clot properties before and after treatment, including in women with endometriosis. The goal is to understand risks an…

This study looks at how pesticides and the bacteria in the gut and reproductive tract might affect infertility in women with endometriosis. Researchers will compare 160 women with and without endometriosis to find patterns in DNA damage and bacterial signatures. The goal is to be…

This study is looking for better ways to diagnose endometriosis and adenomyosis, two conditions that can cause pain and fertility problems. Researchers will collect blood and fluid samples from 530 women, including those with these conditions and those seeking fertility treatment…

This study aims to understand how a hormone-suppressing drug (Relugolix Combination Therapy) affects pelvic pain, inflammation, and pain sensitivity in women with moderate-to-severe endometriosis. Researchers will measure changes in blood markers and brain activity to see how the…