COLON CANCER

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in adults with advanced solid tumors (such as lung, colon, pancreatic, or brain cancer) that have not responded to or cannot tolerate standard treatments. The study has two …

This study tests a combination of two treatments (fruquintinib plus FOLFIRI) in people with metastatic colorectal cancer whose disease has worsened after first-line therapy. About 60 participants will receive the drug combo to see if it can stop or slow cancer growth. The goal is…

This early-stage study tests a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors (such as lung, stomach, colon, rectal, esophageal, or pancreatic cancer) that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study tests whether giving immunotherapy before surgery can help completely remove T4 colon cancer in people whose tumors have a specific DNA repair problem (dMMR). About 18 adults aged 18-75 with newly diagnosed, non-spread colon cancer will receive immunotherapy first, the…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 80 participants will receive the drug through an IV, and r…

This study tests a less invasive surgery for people with early-stage colon cancer (stage I). Instead of removing a large section of the colon, doctors will remove only the tumor and a few key lymph nodes using a special dye. The goal is to see if this gentler approach can reduce …

This study compares a new, less invasive procedure called endoscopic full-thickness resection (eFTR) to standard surgery for early-stage colon cancer. About 434 adults with small, low-risk tumors will be randomly assigned to one of the two treatments. The goal is to see if eFTR i…

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor, then block that artery with tiny beads. This traps the chem…

This study tests a new approach for people with a hard-to-treat type of colon cancer (pMMR/MSS). The treatment combines low-dose radiation (sparing lymph nodes), chemotherapy, and an immunotherapy drug (PD-1 inhibitor) before surgery. The goal is to see if this combination can ma…

This study tests a new combination of chemotherapy drugs (TAS-102, oxaliplatin, irinotecan) plus bevacizumab for people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this approach can control the disease and slow its gro…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This study is testing whether cleaning out the bowel before laparoscopic colon cancer surgery reduces the risk of infections. About 74 people with colon cancer will be randomly assigned to receive or skip bowel preparation. The main goal is to see if bowel prep lowers surgical si…

This study tests whether giving chemotherapy plus an immunotherapy drug before surgery can help people with locally advanced colon cancer. About 56 adults with a specific type of colon cancer will receive the treatment and then have standard surgery. The main goal is to see if th…

This early-stage study tests a new drug called PHN-012, which is designed to deliver a powerful cancer-killing agent directly to tumor cells. It is for people with advanced colon, pancreatic, or lung cancer who have tried other treatments without success. The main goals are to ch…

This study tests a new drug called QL1706 given before surgery for people with a specific type of colon cancer (MSI-H/dMMR) that has not spread too far. About 363 participants will either get QL1706 or standard treatment. The goal is to see if QL1706 can make the tumor disappear …

This study looks at two ways to treat colon cancer that has blocked the bowel. One group gets emergency surgery right away. The other group first gets a stent (a small tube) or a stoma (an opening in the belly) to relieve the blockage, then has surgery later. Researchers will com…

This study tests if giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer get the full planned treatment. About 232 adults with stable tumor genetics will be randomly assigned to standard care or the new approach. The goal is to see if …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study compares laparoscopic (keyhole) surgery to traditional open surgery for removing the right side of the colon in people with right colon cancer. Both surgeries use a special technique called complete mesocolic excision (CME) to remove the cancer and surrounding tissue. …

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This study aims to improve how doctors see digestive system cancers (like liver, stomach, and pancreatic cancer) using special PET/CT imaging probes. Researchers will test these probes in 400 adults to measure how they spread in the body and how well they find tumors. The goal is…

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study is testing a new blood test that uses laser light and artificial intelligence to find signs of five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will collect blood samples from 1,400 people aged 45 and older who are su…

This study is testing a new type of PET scan that uses a special tracer called 18F-FAPI-74 to see if it can find colon cancer that has spread to lymph nodes or other organs better than current scans. About 100 people with colon cancer will get this scan, and researchers will comp…

This study tests if wearing surgical gloves during oxaliplatin treatment can prevent hand nerve damage (peripheral neuropathy) in colon cancer patients. About 84 adults with high-risk stage III or stage IV colon cancer will be randomly assigned to wear gloves or not. The goal is …

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests whether giving the numbing drug lidocaine through a vein during colon cancer surgery can reduce pain, lower the need for strong painkillers, and help the bowels start working again sooner. About 100 adults having laparoscopic colon cancer surgery will be randomly…

This study looks at whether yoga and mindfulness can improve the emotional, social, and physical well-being of people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect inflammation and gene activity. About 100 a…

This study is testing an 8 to 12 week exercise program for people who have or had cancer. The program includes supervised exercise classes, either online or in person, twice a week. The goal is to help participants increase their physical activity and reduce cancer-related sympto…

This study looks at whether giving lidocaine (a numbing medicine) or high-dose dexamethasone (a strong anti-inflammatory) during colon cancer surgery can help the immune system recover better afterward. About 100 adults having colon cancer surgery will be randomly assigned to rec…

This study tests a special home-care program for frail patients aged 65 and older after colon cancer surgery. The program includes diet advice, exercise guidance, and health check-ups at home. Researchers want to see if this extra support helps patients feel better and recover fa…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study is testing a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with solid tumors like lung, breast, or colon cancer…

This study looks at whether preserving the left colic artery during surgery for colon, rectal, or ovarian cancer helps keep the remaining colon well-supplied with blood. About 50 adults scheduled for surgery will have their colon's blood flow measured with and without the artery …

This study looks at whether adding a geriatrician to the care team can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online fitness questionnaire is easy to use and if geriatric c…

This study looks at how the bacteria in your gut and what you eat might influence diarrhea caused by chemotherapy in people with colon cancer. Researchers will collect stool samples and diet surveys from 11 participants before and during treatment. The goal is to find patterns th…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study looks at whether a special nutritional supplement (HMB and vitamin D) combined with a structured exercise program can help adults with colon cancer regain muscle strength and improve recovery after surgery. About 120 participants will be randomly assigned to different …

This study looks at people who have a gene variant (called a secondary finding) found during genetic testing. Researchers want to learn how these variants affect health and how people understand and share their results. Up to 5,000 participants will complete surveys, phone interv…

This study looks at whether a special stitch material (MonoPlus®) can lower the chance of leaks where the bowel is reconnected after colon cancer surgery. About 249 people having this surgery will be followed for 30 days. The goal is to see if this material works as well as or be…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma. Researchers will collect DNA and blood samples from people who have these cancers and their family members. No treatment is given—the goal is to learn more about why…

This study follows 368 colorectal cancer survivors aged 25 to 65 to see how their quality of life changes 6, 12, and 24 months after finishing treatment. Researchers will use questionnaires to measure physical, mental, and social well-being, as well as any long-term side effects.…

This study aims to develop a machine learning tool that analyzes tiny particles called exosomes in the blood to better determine how aggressive a person's colon cancer is before surgery. By combining this molecular information with standard clinical assessments, doctors hope to m…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study looks at whether a blood test that detects tiny bits of tumor DNA (called ctDNA) can help doctors better manage gastrointestinal cancers like pancreas, colon, and bile duct cancer. About 100 adults with these cancers will provide blood and stool samples to see if certa…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, researchers check participants' health each year for 15 years to watch for any long-term side effects. The goal is to make sure th…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genes in the samples and link them to patient health details. The study does not provide any treatment, but pa…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study will collect genetic information and health records from 25,000 people who have cancer or are at risk for it. The goal is to learn more about what drives cancer and how to better tailor treatments. Participants will not receive a new therapy, but their data may help fu…

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colorectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death and injury occurs. The go…