COLON CANCER

This study tested a combination of three drugs (encorafenib, binimetinib, and cetuximab) given before surgery to people with a specific genetic type of colorectal cancer (BRAF V600E). Only 2 people took part. The main goal was to see how much the tumor shrank after treatment and …

This early-phase study tested whether giving specially activated cord blood natural killer (CB-NK) cells along with the drug cetuximab could clear minimal residual disease (MRD) in 15 colon cancer patients who had completed standard treatment but still had cancer DNA in their blo…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. While not a cure, it aims to give patients mo…

This early-phase study tested the safety and best dose of two drugs—regorafenib and nivolumab—given together to people with advanced colorectal cancer that has not responded to standard treatments. The cancer type studied is mismatch repair proficient, meaning it does not have a …

This study looked at whether a combination of daily vitamin D, aspirin, exercise, and a low-fat diet could reduce the chance of colorectal cancer returning in people who had already been treated. Sixteen participants with no visible cancer but with signs of leftover disease in th…

This study tested a new treatment for people with advanced gastrointestinal cancers that had spread and stopped responding to standard therapies. Doctors took immune cells from each patient's tumor, used CRISPR gene editing to remove a gene called CISH that slows down the immune …

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 adults with a specific type of metastatic colon cancer (KRAS/NRAS/BRAF wild-type). The goal was to see if the combination could shrink or stop tumor growth. The study is complete, and results will help…

This study looked at how well people aged 75 and older with stage III colon cancer handle chemotherapy after surgery. Researchers measured changes in daily living activities, side effects, and quality of life. The goal is to better identify which older patients can benefit from c…

This study tested a new blood test designed to find colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45 to 85 gave a blood sample before their routine colonoscopy. The goal was to see how well the blood test could detect cancer and advanced growths com…

This study tested whether offering a simple blood test (Guardant SHIELD) helps more people complete colorectal cancer screening compared to usual care. About 2,000 adults aged 45-75 who had not returned their stool test took part. The main goal was to see how many got screened wi…

This study tested two standard pain control methods after colon or rectal surgery: a local anesthetic delivered through small tubes placed near the surgical site (preperitoneal analgesia) versus an epidural. About 98 adults having planned surgery took part. The goal was to see if…

This study looked at whether a supervised exercise program can help people with breast or colon cancer feel better and have a better quality of life. 78 patients either did supervised exercise for 6 weeks or received usual care. Researchers measured quality of life, fatigue, and …

This study looked at 200 adults having elective colorectal surgery for conditions like colon cancer or diverticulitis. It compared two pain management methods: a TAP block (injection of numbing medicine into the abdominal wall) and epidural anesthesia (medicine delivered near the…

This study looked at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) can reduce the risk of low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. The trial involved 80 adults …

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connected patients with specialists like physiotherapists, dietitians, and psychologists based on their needs. The goal was to improve quality of life …

This study looked at three different screening methods—colonoscopy, a pill-sized camera (colon capsule), and a stool test—to see how well they find colorectal cancer or advanced growths in people aged 45 and older who have a close relative with colorectal cancer. The goal was to …

This study tested whether an educational session at a church could help Spanish-speaking Latinos learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty adults attended a session with videos and questionnaires, and 20 also gave one-on-one in…

This study tested an AI system called EndoStyle that can transform colonoscopy images to look like they came from different types of equipment. 40 doctors with colonoscopy experience were shown real and AI-transformed images to see if they could tell the difference. The goal is t…

This study followed 3,647 people with early to mid-stage colon cancer who had surgery to remove the tumor. Researchers tracked where cancer had spread to nearby lymph nodes and how much bowel was removed. The goal was to find the best surgical approach to improve long-term outcom…

This study looked at 1,471 people with colon cancer to see how their tumor's DNA repair system (called mismatch repair status) relates to where cancer spreads in lymph nodes and how long patients live. Researchers compared two types: pMMR (normal repair) and dMMR (defective repai…

This study looked at 320 men to find out whether a digital rectal exam works better when the patient lies on their back or on their side. The goal was to see which position allows the doctor to feel the entire rectum more completely. Participants had conditions like colon cancer,…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Houston-area households to understand how culture and family relationships help or hinder health conversatio…

This study looked back at over 7,000 people who had surgery for stage I to III colon cancer to see how the cancer's stage and lymph node involvement affect the chance of it returning. The goal was to find patterns in where the cancer comes back (like in the liver or lungs) and ho…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested a 12-week web-based diet program with text messaging for 50 colorectal cancer survivors. The goal was to see if the program was easy to use and could help people eat more vegetables, whole grains, and fish while cutting back on red meat and sugary drinks. All pa…

This study looked at 70 people with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it affects recovery. Researchers measured muscle strength, mass, and physical performance before surgery, then tracked complications and hospital stay le…

This study looked at how DNA from tumors changes in the blood before, during, and after cancer surgery. Thirty adults with breast, prostate, or colon cancer had blood samples taken to measure these DNA levels. The goal was to understand the natural changes, not to test a treatmen…

This study reviewed how closely eight hospitals in Rome followed Enhanced Recovery After Surgery (ERAS) protocols for 1,000 patients having colon surgery for cancer or diverticulum. The goal was to see which recovery steps were used and how they affected complications and hospita…

This study looked at 1500 people with colon cancer to see if a new way of staging the disease—based on where cancer is found in lymph nodes and the number of tumor deposits—could better predict survival than the current system. Researchers collected medical records and followed p…

This study looked at whether text message reminders work better than phone calls to get people to finish their at-home colon cancer screening test (FIT). Over 1,200 adults from NYU family health centers took part. The goal was to see if texts lead to more tests completed within 7…

This study looked at whether practicing mindfulness can reduce chronic stress and lower colon cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods. Twenty-four women who had a past colon polyp and reported high stress took part. The goal was …