COLON CANCER

This study tested a combination of three targeted drugs given before surgery for patients with a specific type of localized colon cancer that has a BRAF V600E mutation. The goal was to see if the drugs could shrink the tumor to make surgery more effective. After surgery, many pat…

This early-phase trial tested a new type of gene therapy for advanced gastrointestinal and other cancers. Researchers collected a patient's own white blood cells, genetically modified them in a lab to recognize and attack cancer cells with a specific mutation called KRAS G12D, an…

This study investigated whether older adults (age 75+) can tolerate standard chemotherapy after surgery for stage III colon cancer. Researchers compared patients who received 6 months of chemotherapy pills to those who were simply observed. The main goal was to see if the treatme…

This study tested a new combination treatment for people with colon cancer who had surgery and chemotherapy but still had tiny amounts of cancer left in their blood. The treatment used specially prepared immune cells (CB-NK cells) from donors, given along with the drug cetuximab.…

This study tested whether a combination of daily aspirin, vitamin D, a low-fat diet, and regular exercise could help prevent colorectal cancer from coming back. It involved 16 patients who had completed their main cancer treatment but still had tiny traces of cancer DNA in their …

This early-phase trial tested a new cell therapy for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Researchers collected a patient's own immune cells from a tumor, used CRISPR gene editing to remove a molecular 'brake' (CISH), a…

This study tested whether combining two targeted drugs, palbociclib and cetuximab, could help control advanced colon cancer that has spread. It involved 24 patients whose cancer had specific genetic features and who had already tried other treatments. The goal was to see if hitti…

This study tested the safety and best dose of a combination of two drugs, regorafenib and nivolumab, for people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to see how much of the drug combination patients could tolerate an…

This study tested a new web and text message program designed to help people who have had colorectal cancer eat healthier. Researchers wanted to see if the program was easy to use and acceptable to 50 cancer survivors over 12 weeks. The goal is to help survivors make dietary choi…

This study tested whether offering a simple blood test could get more people screened for colon cancer compared to standard reminders for stool tests. It involved over 2,000 adults aged 45-75 who were behind on their recommended screenings. Researchers compared how many people in…

This study aimed to find out if one patient position is better than another for doctors performing a digital rectal exam, a common check for conditions like colon cancer. It involved 320 male participants with various conditions like cancer or rectal bleeding. Researchers randoml…

This study compared three different screening methods for colon cancer in people with a family history of the disease. Researchers tested whether a swallowable camera capsule or a simple annual stool test could be as effective as traditional colonoscopy. The goal was to find safe…

This study tested whether a simple blood test using artificial intelligence could detect colorectal cancer early. Researchers collected blood samples from nearly 49,000 average-risk adults aged 45-85 who were already scheduled for routine colonoscopy screening. The goal was to se…

This small pilot study tested whether an 8-week mindfulness program could help reduce chronic stress and related biological factors that may increase colon cancer risk. It involved 24 Black women, aged 45-65, living in high-stress Chicago neighborhoods who were already at elevate…

This study tested whether sending text message reminders helps more people complete their at-home colon cancer screening test (called a FIT kit) compared to the usual phone call reminders. Researchers enrolled over 1,200 adult patients from NYU family health clinics. They measure…

This study tested whether a coordinated, personalized rehabilitation program could improve life quality for people recovering from colorectal cancer. 150 patients in Slovenia were assigned to either receive standard care or a new program that connected them with specialists like …

This study tested whether a 6-week program of supervised exercise could improve quality of life and reduce fatigue for people with breast or colon cancer. 78 patients were randomly assigned to either follow the exercise program or receive their usual care, and their progress was …

This study compared two methods for managing pain after planned colon or rectal surgery. Researchers tested a newer nerve-block injection (TAP block) against the traditional epidural to see which better controlled pain and improved recovery. The trial involved 200 adults undergoi…

This study compared two standard methods for controlling pain after colon or rectal surgery. Researchers tested whether a simpler method using a local pain medication catheter placed near the surgical site works as well as the more complex epidural method. They measured patients'…

This study tested whether a special high-flow nasal oxygen device could help prevent low oxygen levels during sedated endoscopy procedures. It focused on 80 patients at high risk for obstructive sleep apnea who were undergoing stomach or colon exams. Researchers compared breathin…

This study aimed to understand the best ways to encourage Mexican American family members to talk about their risk for common diseases like diabetes, heart disease, breast cancer, and colon cancer. Researchers worked with 498 adults from multigenerational households to see if pro…

This study tested whether Spanish-language educational videos about colorectal cancer, delivered in a church setting, could increase knowledge and willingness to participate in cancer clinical trials among Latino adults. Researchers recruited 60 Spanish-speaking Latino churchgoer…

This study aimed to understand how cancer-related DNA in the blood changes before, during, and after surgery. Researchers measured specific DNA fragments in 30 patients undergoing surgery for breast, prostate, or colon cancer. The goal was to gather baseline information to help f…

This study looked at 1500 colon cancer patients to see if a new way of classifying lymph node spread could better predict survival. Researchers analyzed patient records to compare their new classification system against the current standard method. The goal was to help doctors mo…

This study tested whether smartphones and smartwatches could be used to reliably measure symptoms like fatigue and changes in activity in cancer patients. Researchers enrolled 49 adults with various cancers who were already receiving treatment. They used iPhones and Apple Watches…

This study tested a new AI system called EndoStyle that can change the look of colonoscopy images to match different medical equipment brands. Doctors experienced in colonoscopy viewed sequences of images and tried to identify which ones were altered by the AI. The goal is to see…

This study looked back at medical records of 7,259 colon cancer patients who had surgery to remove their tumors. Researchers analyzed how the size of the original tumor and whether it had spread to lymph nodes influenced if and where the cancer came back. The goal is to better un…

This study looked at 1,471 colon cancer patients to understand how a specific protein status in the tumor (called MMR status) relates to how the cancer spreads to lymph nodes and patient survival. The goal was to gather evidence to help doctors decide the best extent of lymph nod…

This international study aimed to find the best amount of bowel and surrounding lymph nodes to remove during colon cancer surgery. Researchers observed over 3,600 patients who had surgery to see how far the cancer had spread. The goal was to gather evidence to help surgeons decid…

This study aimed to understand how common muscle loss (sarcopenia) is in people about to have colorectal cancer surgery and how it affects their recovery. Researchers followed 70 patients, measuring their muscle strength, mass, and physical ability before surgery. They then track…

This study checked how closely eight hospitals in Rome followed established recovery guidelines for patients having colon surgery for cancer or diverticulitis. It involved 1000 patients and aimed to see if following the guidelines more closely led to fewer complications and short…