COLON CANCER

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore the natural balance of gut bacteria, which is often disrupted by the procedure. Researchers will compare changes in gut bacteria diversity between 30 adults who receive the suppleme…

This study tests a combination of team-based clinic changes and a patient app to help more people complete a colonoscopy after an abnormal stool-based cancer screening. About 2,000 adults who speak English, Spanish, or Cantonese and had an abnormal FIT result will take part. The …

This early-stage study tests an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal is to find a safe dose and see how the body handles the drugs. Participants must …

This study tests if the drug cemiplimab can control a specific type of colon cancer (called dMMR) without needing surgery. About 50 adults with this cancer type will receive the drug to see if it shrinks or stops the cancer. The main goal is to check for side effects and see how …

This study tests a two-drug combination (cabozantinib and nivolumab) in people with advanced colorectal cancer that is microsatellite stable (MSS) and has stopped responding to standard treatments. The goal is to see if the combination can control the cancer for at least 16 weeks…

This study tests an experimental pill (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug targets a DNA repair protein to try to shrink tumors. The trial will check safety, side effects, and how well the drug works alone …

This study tests an oral drug called selpercatinib in people with advanced solid tumors that have a specific RET gene change. The goal is to see if the drug is safe and can shrink tumors. About 857 adults with lung, thyroid, colon, or other cancers took part. The drug is taken by…

This study tests whether giving chemotherapy before surgery can help prevent colon cancer from coming back. It involves 708 adults with locally advanced colon cancer that has not spread. The goal is to see if this approach improves survival and reduces the chance of recurrence co…

This study compares two cold (no heat) methods for removing colon polyps: piecemeal resection (taking it out in pieces) and endoscopic mucosal resection (removing it in one piece). About 570 adults with polyps 10-19mm will be randomly assigned to one method. The goal is to see wh…

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic mutation called KRAS G12C. The main goals are to find a safe dose and understand how the drug moves through the body. About 44 adults …

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded to standard treatments. The goal is to find a safe dose and see if the treatment can shrink tumo…

This study compares giving chemotherapy before surgery (3 cycles) to the standard approach of surgery followed by 8 cycles of chemo in 250 people with locally advanced colon cancer. The goal is to see if the pre-surgery chemo can reduce or eliminate the need for post-surgery chem…

This study looked at whether starting chemotherapy 10 to 14 days after surgery for stage III colon cancer is safer and more effective than the usual approach of waiting more than 2 weeks. About 300 patients took part. The goal was to see if earlier treatment improves the chance o…

This early-phase trial tests a new drug called adagrasib (MRTX849) combined with two other drugs (cetuximab and irinotecan) in people with colorectal cancer that has a specific genetic change (KRAS G12C). The main goal is to find a safe dose and check for side effects. About 24 a…

This study follows 150,000 adults in the U.S. who were prescribed the Cologuard stool test for colorectal cancer screening. Researchers want to see how many people get a follow-up colonoscopy after a positive result, how often cancer is found, and whether the test helps lower dea…

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This early-phase study tests whether a compound from green tea, EGCG, can help prevent colon cancer from returning after surgery. About 51 patients who had their colon cancer removed will take EGCG or a placebo. Researchers will check for changes in DNA markers linked to cancer r…

This study tests a new fluorescent clip that helps surgeons see exactly where a colon tumor is during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to get either the clip or a standard dye injection before surgery. The goal is to see if …

This study tests whether using a FitBit and mobile health apps can help people who have had surgery for cancers of the stomach, liver, pancreas, colon, or small intestine avoid being readmitted to the hospital. About 107 adults who own a smartphone and are scheduled for surgery w…

This study looks at whether cryotherapy (cooling therapy) can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colon cancer. About 40 participants will use cryotherapy during their standard chemo treatment. The goal is to see if this …

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have a stoma after digestive surgery. About 70 adults with a permanent or long-term ostomy will take part. They will attend workshops and get follo…

This study tests whether a 6-week online program based on acceptance and commitment therapy can reduce anxiety and depression in cancer survivors. 32 people who finished treatment for breast, colon, or related cancers will be randomly assigned to the program or a waitlist. The go…

This study looks at whether a special payment model helps doctors coordinate care better for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who are getting chemotherapy. The goal is to see if this approach improves health outcomes and low…

This study looks at whether using a physical activity questionnaire, along with exercise coaching and self-monitoring, can help breast and colon cancer survivors become more active and spend less time sitting. About 20 survivors aged 50 and older who finished their main cancer tr…

This study looks for brand-new gene changes that appear in a child but not in their parents, which might raise the risk of certain cancers. Researchers will compare DNA from cancer patients and their healthy parents to spot these changes. The goal is to better understand cancer r…

This study looked at whether certain genes that make people more prone to bleeding can cause a stool test for colon cancer to show a false-positive result. Researchers planned to collect saliva samples from people who had a raised stool blood test but a normal colonoscopy, and co…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study collects DNA from over 21,000 New York cancer patients to look for inherited gene changes linked to several cancer types. It is an exploratory project that does not offer treatment but aims to find clues for future research. Participants include people with breast, col…

This study tests a program called IGNITE-TX that uses a website and a genetic family navigator to help relatives of people with hereditary cancer get free genetic counseling and testing. It involves 205 adults who have a known cancer gene mutation and their at-risk family members…

This pilot study looks for better ways to find out if colon cancer might spread to the liver. Researchers are testing new imaging and lab tests in 51 people having surgery for colon cancer or benign colon growths. The goal is to improve early detection and guide future treatment.

This study looks at how exercise might affect the body's processes that could stop colorectal cancer from returning. Researchers are measuring changes in blood markers linked to inflammation and cancer cells in 60 people who have finished their cancer treatment. The goal is to un…

This study looks at two different surgeries for a rare type of colon cancer located at the splenic flexure. About 140 patients will be enrolled to compare a smaller surgery (removing only the tumor section) with a larger one (removing more colon and lymph nodes). The goal is to s…