COLON CANCER

This early-stage study tests a new cell therapy called KT032 in 24 adults with advanced solid tumors (ovarian, mesothelioma, or colon cancer) that have spread in the belly. The main goals are to check safety and find the best dose. Participants must have tried standard treatments…

This study tests a drug called fruquintinib in 88 adults with advanced colon cancer that no longer responds to standard chemotherapies. The drug is given along with extra care to manage side effects like high blood pressure and hand-foot syndrome. The goal is to see if it can slo…

This study tests whether two immunotherapy drugs (cemiplimab and fianlimab) can safely shrink colon tumors before surgery in people with stage II-III colon cancer that hasn't spread. Participants get two IV doses, then surgery, and are followed for up to three years. The goal is …

This study tests a new drug combination (iparomlimab and tuvonralimab, called QL1706) plus chemotherapy (XELOX) given before surgery to people with stage III colon cancer that is MSS/pMMR. The goal is to see if this treatment can completely eliminate the tumor by the time of surg…

This study looks at where cancer spreads to lymph nodes in people with colorectal cancer. Researchers will track 1,200 patients for at least 5 years after surgery to map these patterns. The goal is to help doctors better understand and treat the disease in the future.

This study aims to find out if people with metastatic breast or colon cancer produce antibodies that might also attack the heart, potentially causing dangerous heart rhythms. Researchers will test blood samples from 196 participants at the start of the study and again after 6 and…

This study looks at where colon cancer spreads to lymph nodes in the small bowel area for people with cecal or early ascending colon cancer. Researchers will examine tissue removed during surgery to find patterns of spread. The goal is to help surgeons decide how much bowel to re…

This study looks at whether a 6-month or 12-month follow-up colonoscopy is better for people who had a large colon polyp (20-50 mm) removed. The goal is to see which schedule finds any regrowth of the polyp sooner. About 546 adults will take part, and the results will help doctor…

This study looks at how a personalized strength training program affects people with different cancers (lung, colon, breast, lymphoma, and leukemia). 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers will…

This study looks at why some people who had surgery for colon cancer continue to have loose stools. Researchers will use a new device to check for bile acid problems and bacterial overgrowth in the small intestine. The goal is to better understand these symptoms and how they affe…