ATRIAL FIBRILLATION (AF)

This study tests whether SGLT2 inhibitors, a type of diabetes drug, can improve the heart's upper chamber function in people with intermittent atrial fibrillation, high blood pressure, and abnormal blood sugar. The goal is to prevent heart failure. About 66 adults will receive ei…

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 people with atrial fibrillation will be random…

This study compares a new pulsed field ablation (PFA) catheter to standard heat or cold ablation for treating atrial fibrillation (AF) in 136 adults. Participants are randomly assigned to receive either the new PFA device or standard thermal ablation. The goal is to see if the ne…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can reduce the amount of AF or prevent it from becoming a full-blown condition. About 520 adults with heart devices will be split into two groups: one gets ear…

This study tests whether re-sterilized (reprocessed) catheters are as safe and effective as new ones for a common heart procedure called pulmonary vein isolation, used to treat atrial fibrillation. About 200 adults with AFib will be randomly assigned to receive either a new or a …

This study looks at 1,200 people with atrial fibrillation (an irregular heartbeat) and heart failure. It compares two treatments: catheter ablation (a procedure to fix the heart's rhythm) plus standard medications, versus medications alone. The goal is to see if ablation reduces …

This study compares a new procedure called electroporation (using targeted electrical pulses to fix heart rhythm) against standard medications for people with early-stage atrial fibrillation and heart failure. 200 participants will be randomly assigned to either the procedure or …

This study compares two ways to prevent stroke in people with atrial fibrillation (an irregular heartbeat) who have already had a brain bleed. One option is a device that closes off a part of the heart where clots often form, requiring only short-term blood thinners. The other is…

This study tests a new approach for people with atrial fibrillation who have received a heart stent. Instead of taking multiple blood thinners together for months, the plan uses just one drug at a time: an antiplatelet for the first month, then a different blood thinner long-term…

This study tests a new way to treat atrial fibrillation (AFib), a common heart rhythm problem that raises stroke risk. The new method, called pulsed field ablation, uses short electrical pulses to destroy only the faulty heart cells while sparing nearby tissues like the esophagus…

This study is testing a new device that uses short bursts of electricity to fix irregular heartbeats in people with atrial fibrillation. About 360 adults aged 18-80 with this condition will receive the treatment. The goal is to see if it safely restores normal heart rhythm and im…

This study looks at how well and how safely a new catheter (Varipulse) can treat a type of irregular heartbeat called non-paroxysmal atrial fibrillation. About 50 adults will get the procedure, which uses energy to create small scars in the heart to block faulty signals. Research…

This study tests a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) using pulsed field ablation, a procedure that destroys tiny areas of heart tissue causing the problem. About 699 adults with persistent AFib that hasn't improved with medication wil…

This study tests a new, personalized approach to treat atrial fibrillation (AF), a common heart rhythm problem. Instead of the standard one-size-fits-all ablation, doctors will use a special mapping system to find and destroy the exact areas causing the irregular heartbeat. The g…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation. About 146 adults aged 18-80 with both conditions will be randomly assigned to either ablation or standard drug therapy. The main goal is to…

This phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation (AF) spend in an irregular heart rhythm compared to a placebo. About 200 adults with paroxysmal or persistent AF will wear a heart monitor to track their A…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests a device called AtriLASH that closes a small heart pouch (left atrial appendage) during planned heart surgery in 200 adults with atrial fibrillation. The goal is to reduce stroke risk and possibly lower the need for long-term blood thinners. Participants will be …

This study looks at two ways to treat atrial fibrillation (an irregular heartbeat) in people who also have heart failure with preserved or mildly reduced heart function. Participants will be randomly assigned to either a procedure called catheter ablation to restore normal rhythm…

This study tests a new catheter system (Sphere-9 and Affera) for a repeat heart ablation procedure in people whose atrial fibrillation (AFib) came back after a first ablation. About 400 adults with recurrent symptomatic AFib will be treated and followed for 12 months. The goal is…

This study is testing a new circular-shaped catheter that uses pulsed field ablation to treat atrial flutter, a type of irregular heartbeat. Researchers want to see if it is safe and effective. About 150 adults with atrial fibrillation or flutter will take part. The procedure is …

This study tests whether giving extra fluids through an IV before and after a new type of heart procedure (pulsed field ablation) can prevent kidney injury in people with atrial fibrillation. About 290 adults will be randomly assigned to receive either standard care or extra flui…

This study tests doing two heart procedures at the same time in people with atrial fibrillation (AF) who are at high risk for stroke but cannot take long-term blood thinners. The first procedure uses pulse field ablation to fix the heart's electrical signals, and the second close…

This study tests whether dapagliflozin, a drug used for diabetes, can reduce the return of atrial fibrillation (an irregular heartbeat) after a procedure called cardioversion that restores normal rhythm. About 1600 adults aged 55 and older with AFib will take dapagliflozin or rec…

This study tests a new way to treat persistent atrial fibrillation (AFib) by using advanced heart mapping to find and burn specific areas that keep the abnormal rhythm going. About 78 adults with long-lasting AFib or dangerous ventricular arrhythmias will take part. The goal is t…

This study tests whether using an artificial intelligence system (vMap) to find and burn extra heart tissue, along with the standard procedure, helps people with atrial fibrillation stay free of the condition longer. About 423 adults with persistent or recurrent AF will be random…

This study looks at a new way to pace the heart called left bundle branch area pacing (LBBAP) for people with conditions like slow heartbeat, heart failure, or atrial fibrillation. About 200 adults will get a special pacemaker lead, and researchers will track safety issues like i…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful heart ablation procedure. About 4,100 adults who have been free of AF for at least 2 months after ablation will either stop or continue their blood thinner. E…

This study tests whether using a non-invasive body-surface map to guide catheter ablation can better treat atrial fibrillation (AF) compared to the standard approach. About 45 adults with persistent AF and an enlarged left atrium will receive a personalized ablation based on this…

This study tests if a newer pacemaker method (left bundle branch pacing) can reduce the time spent in fast heart rate episodes compared to standard pacing. About 244 adults who need a pacemaker for heart block and have normal heart function will be randomly assigned to one of the…

This study tests a monthly injection called abelacimab to prevent strokes in about 1,900 people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard oral blood thinners. Participants will receive either the study drug or a placebo. The goal is to see …

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (AF) in people who recently had a stroke or mini-stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual care wi…

This study tests whether wearing a portable ECG monitor for 30 days after transcatheter aortic valve replacement (TAVI) can detect dangerous heart rhythm issues better than the usual short hospital monitoring. 250 adults with severe aortic stenosis will be randomly assigned to ei…

This study tests whether an artificial intelligence system can help doctors spot hidden atrial fibrillation (AF) early by analyzing standard ECG results. About 15,000 patients will be randomly assigned to have their ECGs reviewed with or without the AI alert. The goal is to see i…

This study tests whether a special blood pressure monitor (TH-75) can accurately detect atrial fibrillation, a common heart rhythm problem. About 392 adults—some with AF and some without—will use the monitor, and its results will be compared to a standard heart test. If successfu…

This study looks at whether using a 7-day heart monitor can help find hidden atrial fibrillation (an irregular heartbeat) in people with high NT-proBNP levels, a sign of heart strain. 4,000 adults without known AF will be split into two groups: one gets the monitor, the other doe…

This study tests if placing a biodegradable patch soaked with the heart drug amiodarone directly on the heart during surgery can prevent atrial fibrillation (a common irregular heartbeat) afterward. About 500 adults having elective open-heart surgery will be randomly assigned to …

This study tests whether a 12-week digital MediYoga program—combining deep breathing, gentle yoga, and meditation—can improve quality of life, blood pressure, and heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get online suppor…

This study compares two catheters used to treat atrial fibrillation (AFib) by isolating the pulmonary veins. The newer catheter has built-in navigation that may eliminate the need for a pre-procedure CT scan, reducing radiation exposure and costs. About 58 adults with AFib who ar…

This study tests whether a supervised exercise program before a common heart procedure (catheter ablation) can help people with atrial fibrillation recover better. About 100 adults aged 18-70 will be randomly assigned to either the exercise program or usual care. The goal is to s…

This study tests if a new device called AccuSafe guidewire is safer and more effective than the traditional needle used to cross the wall between heart chambers during a procedure for atrial fibrillation (an irregular heartbeat). About 144 adults with atrial fibrillation will be …

This study looks at whether a procedure called catheter ablation can improve quality of life in people aged 80 and older who have atrial fibrillation (an irregular heartbeat). Participants will be randomly assigned to receive either the real procedure or a sham (fake) procedure. …

People with serious mental illness often have undiagnosed physical problems like heart disease, diabetes, or cancer. This study adds routine health checkups to psychiatric clinics to see if they catch these hidden conditions better than usual care. About 2,800 adults with psychot…

This study follows 100 people who had a new episode of atrial fibrillation (AF) during a hospital stay for surgery or medical illness. Participants receive a small implantable heart monitor to track their heart rhythm for up to 12 months. The goal is to see how often AF comes bac…

This study follows 1,200 people with atrial fibrillation (AF) in China who are getting a newer, gentler type of ablation called pulsed field ablation. Researchers want to see if early heart rhythm issues in the first few months can predict if AF comes back later. Participants wil…

This study is testing a new catheter called OPTRELL to better locate the heart areas causing long-lasting atrial fibrillation (AF). Researchers will map the heart's electrical signals during AF and use that information to guide targeted ablation. The goal is to see if this approa…

This study watches sleep patterns in 100 adults with atrial fibrillation who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests (two before and two after the procedure) to see if sleep quality improves. The st…

This study looks at whether certain gene changes make some people more likely to develop a weakened heart muscle (cardiomyopathy) from atrial fibrillation (AF). Researchers will compare DNA from 299 adults with AF and heart failure to those with AF alone or other heart conditions…

This study looks at whether a night of poor sleep can increase abnormal heartbeats in people with obstructive sleep apnea. Researchers will ask 100 adults to wear a heart monitor for 14 days and sometimes skip using their sleep device. The goal is to understand the short-term lin…

This study is testing whether certain heart ultrasound findings can identify people who have hidden atrial fibrillation (AF) but don't know it. Researchers will monitor 3000 participants with abnormal ultrasound results using extended ECG recordings to see if they detect more AF …

This study looks at whether drinking alcohol increases the chance of atrial fibrillation (AFib) episodes in people with a type of AFib that comes and goes. One hundred participants will be randomly assigned to drink or avoid alcohol on different days while wearing heart monitors …

This study tests whether a smartwatch and a digital platform can help doctors spot heart rhythm problems like atrial fibrillation early in people with heart disease. About 520 adults will wear a smartwatch and a standard heart monitor for up to 45 days. The goal is to see if the …

This study looks at why some people with persistent atrial fibrillation (AFib) continue to have heart rhythm problems even after a standard ablation procedure. Researchers will create detailed 3D maps of the heart's electrical activity and scar tissue in 160 adults having their f…

This study will follow 30,000 people aged 60 and older in Qujiang, China, who have chronic heart conditions like high blood pressure, heart failure, or atrial fibrillation. Researchers want to see if a program combining medication, lifestyle advice, education, and regular check-u…

This study collects information from 1,000 people who have had or will have a heart rhythm procedure at University Hospital Düsseldorf. The goal is to track how safe and effective these standard procedures are in everyday practice. No new treatments are being tested; instead, res…

This study looks at whether using a special CT scan in the emergency department to rule out blood clots before restoring normal heart rhythm can help people with atrial fibrillation or atrial flutter. About 190 adults will be randomly assigned to either the CT-scan approach or us…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in people with a type of irregular heartbeat called paroxysmal atrial fibrillation. Researchers will measure changes in heart function using ultrasound during the procedure. The…

This study watches 40 adults with atrial fibrillation who get a new heart procedure called pulsed field ablation. The goal is to see if tiny, symptomless spots appear on brain scans afterward. Researchers want to learn how safe this new technique is for the brain.

This study is testing whether a wearable, AI-enhanced heart monitor worn for 7 days can find more cases of atrial fibrillation (an irregular heartbeat that raises stroke risk) than usual care in people aged 60 and older living in rural China. About 15,360 participants from 128 vi…