ATRIAL FIBRILLATION (AF)

This study compares two ways to treat persistent atrial fibrillation (AF), a heart rhythm problem. One group gets the standard procedure (isolating the pulmonary veins), while the other gets that plus extra scar lines in the heart. The goal is to see which approach better prevent…

This study tests whether a new catheter ablation method using pulsed field energy can better control persistent atrial fibrillation (a type of irregular heartbeat) than standard treatment. About 618 adults with persistent AF will be randomly assigned to receive either the new tar…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats after a common heart procedure called catheter ablation. About 120 adults with persistent atrial fibrillation will be randomly assigned to receive either acupuncture plus us…

This study compares two types of medicine for atrial fibrillation (AF), a condition causing irregular heartbeat. About 1,900 adults diagnosed with AF in the past year will be randomly assigned to take either dronedarone or a standard Class Ic drug (like flecainide). Researchers w…

This study compares a new dual electrical shock technique to the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation (an irregular heartbeat). About 177 adults will be randomly assigned to receive either the dual shock or the conv…

This study tests whether dapagliflozin, a drug typically used for diabetes, can help prevent atrial fibrillation from coming back after a heart procedure called catheter ablation. The trial includes 280 adults with persistent AF and increased fat around the heart, but without dia…

This study looks at doing two heart procedures at the same time: using pulsed field ablation to treat atrial fibrillation (an irregular heartbeat) and closing the left atrial appendage to reduce stroke risk. About 500 adults who need both treatments will be followed to see if the…

This study looks at doing two heart procedures at the same time in people with atrial fibrillation (an irregular heartbeat). The first uses targeted energy to fix the heart's electrical signals, and the second closes a small pouch in the heart to lower stroke risk. Researchers wa…

This study compares two heart pacing methods after a procedure to control heart rate in adults with atrial fibrillation and heart failure. Participants will receive either a new type of pacing (conduction system pacing) or standard cardiac resynchronization therapy. The goal is t…

This study tests whether adding fexuprazan, a stomach acid reducer, can prevent upper gastrointestinal bleeding in 1000 people with atrial fibrillation who are taking blood thinners (NOACs). Participants are at high risk for bleeding due to age, kidney problems, or other medicati…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a procedure to fix a leaky mitral valve. Researchers want to see if doing a catheter ablation (a procedure to correct the heartbeat) is better than standard care at preventing seriou…

This study tests two common heart rate-lowering drugs, verapamil and metoprolol, in 436 adults with paroxysmal atrial fibrillation (AF), a condition causing irregular heartbeats. Some participants will also use a smartwatch to track their heart rhythm and guide self-care. The goa…

This study tests whether taking semaglutide (a diabetes/weight-loss drug) before a standard heart procedure called catheter ablation helps prevent atrial fibrillation from coming back. About 240 adults with obesity and symptomatic AF will receive either semaglutide or standard ca…

This study tests whether adding relaxin, a natural hormone, to standard care can reduce abnormal heart rhythms in 208 veterans with atrial fibrillation who are scheduled for a heart procedure called catheter ablation. The goal is to see if relaxin lowers the daily burden of atria…

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes less major bleeding while still preventing blood clots. Participants will be followed fo…

This study tests whether taking probiotics can lower the chance of atrial fibrillation (AF) returning after a procedure called cardioversion, which restores normal heart rhythm. About 56 adults aged 40 and older with persistent AF will take probiotics or a placebo and be followed…

This study will test if using a smartwatch to continuously monitor atrial fibrillation (AF) can help doctors decide when to start or change treatment. About 3,194 people with paroxysmal AF will wear a smartwatch that tracks their AF burden. Those with a high burden will receive e…

This study looks at whether using a CPAP machine for 12 months after a heart procedure (catheter ablation) can lower the chance of atrial fibrillation coming back in people who also have obstructive sleep apnea. About 658 adults aged 18-75 with both conditions will be randomly as…

This study compares the safety of the drug flecainide to standard rhythm-control medications (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least …

This study looks at two different heart procedures for people who have both atrial fibrillation (an irregular heartbeat) and heart failure (a weakened heart pump). The goal is to see which approach—catheter ablation to restore normal rhythm or a pacemaker plus ablation to control…

This study tests whether taking semaglutide (Wegovy) before a standard heart procedure for atrial fibrillation (AF) can help prevent the abnormal heart rhythm from coming back. About 200 adults with AF and overweight or obesity will receive either standard care or semaglutide plu…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study is testing a new type of pacemaker that doesn't need wires (called a leadless pacemaker) in 10 adults with a slow heart rate (bradycardia). The goal is to see if it is safe and works well. The device is placed directly in the heart to help keep the heartbeat steady.

This study looks at two common treatments for atrial fibrillation (an irregular heartbeat) in people aged 78 and older. One treatment is a procedure called catheter ablation, which targets the heart's faulty electrical signals. The other is medication to control heart rate or rhy…

This study looks at two ways to treat atrial fibrillation (AF) that comes back after a first ablation procedure. Sixteen people who still have symptoms despite medication will be randomly assigned to either a repeat ablation or a pacemaker with a special type of pacing plus a pro…

This study tests whether a procedure that closes off a small heart pouch (left atrial appendage occlusion) combined with a heart-rhythm correction (catheter ablation) is safer and more effective than ablation plus daily blood thinners for frail patients aged 75 and older with atr…

This study tests a new way to treat atrial fibrillation (AF), a condition where the heart beats irregularly. The method uses short electrical pulses instead of heat to block faulty signals in the heart. Thirty adults with AF will receive this treatment during a standard procedure…

This study looks at whether people with atrial fibrillation (AF) and prior heart stents can safely stop taking blood thinners if their heart rhythm stays normal for at least a year after AF ablation. Participants will either continue blood thinners or switch to a single antiplate…

This study compares a newer pacing method (left bundle branch area pacing) with the standard approach for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if the newer method improves the heart's pump…

This study tests a new method to treat atrial fibrillation (a common heart rhythm problem) during open-heart surgery. About 200 adults having heart surgery will receive a special procedure that isolates the pulmonary veins using a device called GeminiS. The goal is to see if this…

This study looks at whether staying away from alcohol for six months after a common heart procedure (ablation) can lower the chance of atrial fibrillation (AF) coming back. About 414 adults who drink moderately or more will be split into two groups: one that stops drinking and on…

This study tests a new way to find cardiac amyloidosis—a serious heart condition—early in 500 adults with atrial fibrillation and warning signs. Half will get AI-ECG and CT scans plus usual care, while the other half gets usual care only. Researchers will compare how many cases a…

This study tests whether smartphone sensors and bed sensors can detect supraventricular tachycardia (a fast heart rhythm) in children aged 0-10. Researchers will compare these methods to standard hospital heart monitoring. The goal is to develop a simple, non-invasive way to iden…

This study aims to see if an artificial intelligence (AI) program can accurately detect and predict atrial fibrillation (AF) using data from consumer wearable devices like smartwatches. Researchers will enroll 40 adults with AF to develop and test the AI algorithm against standar…

This study compares an AI-enhanced electrocardiogram (ECG) to the standard echocardiogram for detecting heart problems in 1,724 adults with atrial fibrillation. The goal is to see if the AI-ECG approach is just as safe and effective, potentially reducing the need for more complex…

This study tests a new technology that analyzes a person's voice during short phone calls to detect atrial fibrillation, a common heart rhythm problem. Researchers will enroll 40 adults scheduled for a cardioversion procedure to reset their heart rhythm. Participants will make th…

This study tests two methods—a surgical window or a special drain—to prevent atrial fibrillation (a common irregular heartbeat) and other heart sac complications after coronary artery bypass surgery. About 122 adults having their first bypass will be randomly assigned to one of t…

This large, late-stage study is testing two new injectable drugs, REGN7508 and REGN9933, to prevent strokes and blood clots in people with an irregular heartbeat called atrial fibrillation. The study is specifically for people who cannot or choose not to take standard oral blood …

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. The program starts with resistance training (like lifting weights) to build muscle, then adds aerobic exercis…

This study compares two sedation methods for a heart procedure that checks for blood clots and then delivers a controlled electric shock to restore normal rhythm in people with atrial fibrillation or flutter. Currently, a stronger sedative given by an anaesthesiologist is used, w…

This study tests whether simple nudges—like text message reminders, a medication calendar, and a personal plan—can help people with atrial fibrillation stick to their blood-thinning medication. About 84 adults will be split into two groups: one gets the nudging program plus usual…

This study tests a simple mental exercise called Episodic Future Thinking (EFT) to help people with atrial fibrillation remember to take their blood thinners. 68 participants will either get the EFT training plus usual care, or just usual care. Researchers will check if EFT impro…

This study tests whether a WhatsApp-based chatbot is a practical and helpful way for people to report symptoms and health updates after atrial fibrillation ablation. About 76 adults who had the procedure will either use the chatbot or get standard follow-up care for 3 months. The…

This study tests a new software tool that measures tiny electrical signals in the heart after a procedure called pulsed field ablation (PFA) for atrial fibrillation. About 30 adults with this heart condition will take part. The goal is to find a clear signal level that tells doct…

This study aims to improve how doctors measure heart function in patients who have both heart failure and atrial fibrillation. Current ultrasound methods are not reliable for these patients, making it hard to diagnose and treat them properly. Researchers will test new ultrasound …

This study looks at how closely heart failure and atrial fibrillation patients follow their medication plans after being admitted to the coronary care unit. Researchers will interview 250 adults to check if their prescriptions are appropriate and understand their beliefs about ta…

This study looks at how safe current blood thinner management is for 700 cancer patients who need surgery or medical procedures. Researchers will track bleeding and clotting problems within 30 days after surgery. The goal is to learn how to improve care and lower these risks in t…

This study will collect information and ultrasound images from 1,000 adults who are already having a heart procedure. Doctors will use a special catheter called VeriSight Pro to take pictures inside the heart. The goal is to see if it is safe and works well for guiding treatments…

This study will follow about 3,459 adults in China who have both atrial fibrillation (an irregular heartbeat) and metabolic disorders like obesity or diabetes. Researchers want to learn how these conditions together affect health, such as risk of stroke or heart failure. The goal…

This study is a registry that will follow about 3,500 people with atrial fibrillation (a type of irregular heartbeat) to see how the condition progresses and what treatments are used in everyday medical practice. Participants must be between 18 and 64 years old and have a low ris…

This study looks at how men and women differ in heart structure and procedure results after a first-time ablation for atrial fibrillation. Researchers will compare anatomy, procedure details, and success rates in 700 patients. The goal is to understand these differences to tailor…

This study looks at why women often have more trouble with atrial fibrillation (AF) after standard treatment. Researchers will map the heart's electrical activity in 100 men and women right after a common procedure called pulmonary vein isolation. They want to see if women have m…

This study looks at how well the heart works during exercise in people who have both atrial fibrillation (an irregular heartbeat) and heart failure. Researchers want to see if the current standard of allowing a resting heart rate of 100-110 beats per minute is too high and harms …

This study aims to develop and test an artificial intelligence (AI) model that can better predict the risk of stroke and other major heart problems in people with atrial fibrillation (an irregular heartbeat). Researchers will use data from 1,000 adults aged 65-95 who are at high …

This study will use a small heart monitor (implantable loop recorder) for up to three years to find hidden atrial fibrillation in 100 people with moderate-to-severe mitral valve regurgitation who have few or no symptoms. The goal is to learn how common these hidden heart rhythm p…

This study compares two catheters used during heart ablation for atrial fibrillation. Researchers want to see if one catheter can confirm that the treatment worked faster than the current method. The study involves 30 adults with persistent atrial fibrillation or atrial flutter.

This study looks at why people with hypertrophic cardiomyopathy (thickened heart muscle) often develop atrial fibrillation (an irregular heartbeat) and why standard treatments may not work as well for them. Researchers will study electrical signals and images of the heart in 40 a…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation changes the size and thickness of the heart's upper chambers in people with atrial fibrillation (an irregular heartbeat). Researchers will compare CT scans taken before and 3 months after the…

This study looks at 460 adults who need a pacemaker but have no history of atrial fibrillation. It compares three pacing methods to see which one best reduces brief, undetected rapid heartbeats (atrial high-rate episodes) that can lead to serious rhythm issues. Participants will …

This study will observe 300 adults having planned heart bypass surgery to see if the amount of belly fat (measured by ultrasound before surgery) is linked to a higher chance of developing atrial fibrillation, a common irregular heartbeat, after the operation. The goal is to bette…

This study will follow 10,000 people with atrial fibrillation (AF) for two years to see if the total time they spend in AF (called AF burden) is linked to strokes and blood clots. Participants will use their own smartphones and smartwatches to track their heart rhythm. The goal i…

This study observes 30 adults in Mexico who are already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans, heart CT scans, and body composition tests to see how the drug affects knee cartilage, heart fat, and overall body health over one y…

This study uses CT scans to compare fat around the heart in people with and without atrial fibrillation (AF). Researchers will look at 600 adults to see if fat distribution differs between those with normal rhythm, occasional AF, and persistent AF. The goal is to better understan…

This study looks at 3,000 adults having planned heart surgery to find out if things like genes, blood markers, and even voice recordings can help predict serious complications such as kidney injury, delirium, or bleeding. Researchers will collect samples and data before, during, …