ATRIAL FIBRILLATION (AF)

This study is testing if using a CPAP machine for sleep apnea after a heart procedure helps prevent the irregular heartbeat from coming back. About 660 adults who have both an irregular heartbeat and sleep apnea will be randomly assigned to either use CPAP for a year or receive t…

This study aims to see if the heart medication verapamil works better than the more commonly used metoprolol at controlling heart rate in people with a type of irregular heartbeat called paroxysmal atrial fibrillation (AFib). It will involve 436 adults with symptomatic AFib who n…

This study is collecting information on a combined medical procedure. Doctors perform two tasks at once: they use a special energy (pulse field ablation) to correct an irregular heartbeat (atrial fibrillation), and they place a small device to seal off a part of the heart to help…

This study is testing whether adding a natural hormone called Relaxin to standard catheter ablation treatment can better control atrial fibrillation (AFib) in veterans. Researchers want to see if Relaxin reduces oxidative stress in the heart and lowers how often AFib returns afte…

This study compares two blood-thinning medications for patients who have irregular heartbeat and recently had heart valve surgery. Researchers want to see if a newer medication (apixaban) is as safe and effective as the standard medication (warfarin) during the first three months…

This study is testing if using a weight loss medication before a heart procedure helps patients stay in normal rhythm longer. It will include 200 adults with a common irregular heartbeat who are overweight and scheduled for their first procedure. Participants will either receive …

This study is testing whether a simple WhatsApp chatbot can help people recovering from a procedure for atrial fibrillation (an irregular heartbeat). Researchers want to see if using the chatbot to report symptoms and health updates is easy and helpful compared to standard follow…

This study aims to find out which of two common types of medicine works better for people recently diagnosed with atrial fibrillation (AF), an irregular heartbeat. About 1,900 adults will be randomly assigned to take either the drug dronedarone or a standard 'Class Ic' drug like …

This study is testing whether adding the drug dapagliflozin around the time of a heart ablation procedure can help prevent the irregular heartbeat from coming back. It will involve 280 adults with a specific type of long-lasting atrial fibrillation who have extra fat around the h…

This study is testing if taking the weight-loss medication semaglutide before a standard heart procedure (catheter ablation) leads to better long-term control of atrial fibrillation (AFib) in people who are obese. It will involve 240 adults with symptomatic AFib who are scheduled…

This early study aims to test the initial safety and performance of a new type of leadless pacemaker called the ALPS system in patients with a slow heart rate (bradycardia). Up to 10 participants will have the device implanted and will be followed for 24 months. The key innovatio…

This study compares two different ways to drain fluid after heart bypass surgery. Researchers want to see which method better prevents irregular heartbeats and fluid buildup around the heart. The trial will involve 122 patients having their first elective bypass surgery. Results …

This study is testing whether adding acupuncture to standard care helps prevent the return of a dangerous irregular heartbeat (atrial fibrillation) after a common heart procedure called catheter ablation. It will involve 120 people who have persistent atrial fibrillation and have…

This study is for people with atrial fibrillation (AFib) and a history of a heart stent who have had a successful ablation procedure and have stayed in normal rhythm for at least a year. It aims to find out if it's safe to stop their blood thinner medication and switch to just a …

This study is testing a specific medical device system for people who need a second heart ablation procedure because their irregular heartbeat (atrial fibrillation) has come back. It will enroll about 400 people in the US, Europe, and Australia who have had one prior ablation. Th…

This study tests a new surgical technique performed during planned heart surgery to control atrial fibrillation (AF), a common irregular heartbeat that increases stroke risk. Researchers will use a special device to create scar tissue around heart areas that trigger AF, aiming to…

This study examines whether lowering heart rates in people with both atrial fibrillation (irregular heartbeat) and heart failure improves their ability to exercise and quality of life. Researchers will test 40 patients before and after they receive either an electrical reset of t…

This study is testing if a mental exercise called 'Episodic Future Thinking' can help people with atrial fibrillation (AFib) remember to take their blood-thinning medication. 68 participants will be split into two groups: one group will practice imagining positive future events l…

This study aims to test a new AI tool designed to better predict the risk of strokes and other major heart events in older adults who are at high risk for a common heart rhythm problem called atrial fibrillation (AFib). Researchers will use health records from 1,000 participants …

This trial aims to find the best way to manage atrial fibrillation (AFib) in people who also have heart failure. It will compare two main approaches: using catheter-based procedures to restore normal heart rhythm versus using medications and devices to control the heart rate. The…

This study is testing two different approaches for people whose atrial fibrillation returns after previous ablation treatment. Sixteen participants will be randomly assigned to either receive another ablation procedure or get a pacemaker combined with AV node ablation. The study …

This study compares two approaches to heart ablation for people with persistent atrial fibrillation (AF), a common irregular heart rhythm. Researchers want to see if adding extra ablation lines to the standard procedure works better at keeping the heart in normal rhythm. The tria…

This study is gathering real-world data on patients who receive two heart procedures during a single hospital visit. The first procedure uses pulsed energy to correct an irregular heartbeat (atrial fibrillation), while the second procedure implants a small device to close off a p…

This study aims to find the safer, more effective treatment for frail elderly patients with atrial fibrillation (AFib), a common heart rhythm problem that raises stroke risk. It will compare two approaches: a heart procedure (ablation) combined with a small plug to seal off a par…

This study is testing a newer type of heart procedure called pulsed field ablation (PFA) against the standard heat or cold ablation methods for treating atrial fibrillation (AFib). It will involve 136 adults with AFib who are getting their first procedure to electrically isolate …

This study aims to find the best way to manage atrial fibrillation (AF), a common irregular heartbeat, in people aged 78 and older. It will randomly assign 282 participants to receive either a catheter ablation procedure or optimized medication therapy. Over two years, researcher…

This large Phase 3 study is testing two new injectable drugs, REGN7508 and REGN9933, to prevent strokes and blood clots in people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard oral blood thinners. The study will compare these experimental drugs…

This study is for people whose first atrial fibrillation (AFib) ablation procedure didn't work. It compares two approaches for the second attempt: the standard repeat procedure versus adding treatment to an extra area of the heart. The goal is to see which method better reduces s…

This study is for people who have had a successful, minimally invasive repair for a leaky heart valve (mitral regurgitation) and also have a common irregular heartbeat called atrial fibrillation (AF). Researchers want to see if performing a catheter ablation procedure to fix the …

This study aims to determine if the heart rhythm medication flecainide is as safe as standard drugs (sotalol or amiodarone) for people who have both atrial fibrillation (an irregular heartbeat) and stable coronary artery disease (narrowed heart arteries). Researchers will randoml…

This study is testing whether placing pacemaker wires in specific, more natural locations in the heart is better at preventing irregular, fast heartbeats (called atrial high-rate episodes) than standard placements. It will follow 460 patients who need a pacemaker but have no hist…

This study aims to test if new, less invasive technology can reliably detect a fast heart rhythm condition in young children. Researchers will compare measurements from a smartphone placed on the chest and a special smart mattress to the standard hospital heart monitor. The goal …

This study aims to see if using artificial intelligence to analyze simple ECG heart tracings can effectively screen for heart structure and function problems in people with atrial fibrillation (AF). Researchers will compare this AI-ECG approach to the current standard of routine …

This study aims to see if a consumer smartwatch, combined with artificial intelligence (AI), can accurately predict and detect atrial fibrillation (AF), a common irregular heartbeat. It will recruit 40 adults with a history of AF to wear a smartwatch and compare its readings agai…

This study is testing a computer algorithm designed to predict whether a patient's irregular heartbeat (atrial fibrillation) will return after a common treatment procedure called pulmonary vein isolation. The tool analyzes simple heart signal measurements taken before and during …

This study aims to develop better ultrasound methods to measure heart pressure in people who have both heart failure and atrial fibrillation. Current ultrasound tools are unreliable for these patients, making diagnosis and treatment planning difficult. Researchers will test new t…

This study is testing whether a person's voice during a short phone call can reveal an irregular heartbeat. Researchers are enrolling 40 adults who are scheduled for a procedure to reset their heart rhythm. Participants will make three brief voice recordings to see if the technol…

This study aims to see if giving patients extra IV fluids during and after a heart procedure can prevent kidney damage. It will involve 290 adults with atrial fibrillation who are scheduled for a specific type of heart treatment called pulsed field ablation. Participants will be …

This study is testing a new exercise program designed for older adults who have both a common heart rhythm problem (atrial fibrillation) and a type of heart failure. Researchers want to see if starting with strength training to build muscle makes it easier and more effective to t…

This study aims to understand if the amount and location of fat around the heart differs between people with a normal heartbeat and those with atrial fibrillation (AFib), an irregular heartbeat. Researchers will compare CT scan images from 600 people grouped by their heart rhythm…

This study aims to understand why atrial fibrillation (an irregular heartbeat) is more common and harder to treat in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is abnormally thick. Researchers will study 40 adults with both conditions who ar…

This large observational study aims to better understand how atrial fibrillation (an irregular heart rhythm) and common metabolic disorders like obesity and diabetes interact in Chinese patients. Researchers will follow 3,459 participants over time to track health outcomes, quali…

This large observational study aims to understand the link between the amount of time a person spends in atrial fibrillation (AF) and their risk of having a stroke. It will follow 10,000 people with AF for two years, using their own smartwatches to monitor their heart rhythms, bu…

This study aims to understand if the amount of deep belly fat a person has before heart bypass surgery can predict their risk of developing an irregular heartbeat after the operation. Researchers will use an ultrasound to measure belly fat in 300 patients before their scheduled s…

This study is a large registry that will observe and collect information from 3,500 patients with atrial fibrillation (an irregular heart rhythm) over three years. It aims to understand how the condition is managed in real-world clinics and what happens to patients over time, foc…

This study aims to understand how a newer heart procedure called pulse-field ablation changes the structure of the heart's upper chambers (atria) in people with atrial fibrillation. Researchers will compare detailed CT scans taken before and after the procedure in 200 patients to…

This study aims to understand how men and women respond differently to a common procedure for irregular heartbeats. Researchers will compare 700 patients who had their first treatment for atrial fibrillation, tracking their heart health for one year. The goal is to learn if anato…

This study aims to find out how common hidden, symptomless irregular heartbeats are in people with a significant leak in their mitral heart valve. Researchers will implant a small heart monitor under the skin of 100 participants and track their heart rhythm for up to three years.…

This study aims to test whether new software can properly measure heart electrical signals from different pulsed field ablation catheters. Researchers will collect data from 30 adults with atrial fibrillation who are undergoing a standard heart procedure to isolate their pulmonar…

This study aims to discover early warning signs for serious complications after heart surgery. Researchers will collect blood, voice recordings, and other data from 3000 patients to look for patterns that predict problems like kidney injury, delirium, or irregular heartbeat. The …

This study aims to understand how safe current practices are for managing blood thinners in people with cancer who need surgery or medical procedures. Researchers will observe 700 patients to measure how often serious bleeding or dangerous blood clots happen after surgery. The go…