Mental disorder

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers wil…

This study tests an updated version of the BRITE app, called ViraBrite, which sends suicide safety planning materials and coping skills to teens when they are feeling high emotional distress. Twenty teens who have recently attempted suicide or had suicidal thoughts with a plan wi…

This trial tests a Family Mental Health Navigator (FMHN) program for publicly insured youth aged 6-17 who are already receiving services at a San Francisco hospital. The program pairs families with a navigator who uses mobile health tools to help them get referrals and start trea…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This study looked at whether taking a daily mix of food supplements (like polyphenols and prebiotics) for 12 weeks helps people who recently lost weight with GLP-1 drugs. The goal was to see if it could improve body composition, emotional well-being, and gut health after stopping…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

This trial tests whether short, equipment-free exercise sessions in the classroom can ease anxiety, depression, and stress while boosting physical activity in medical students. Around 105 students will be split into groups receiving either two, one, or no exercise sessions per we…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This study tested a digital toolkit called mSELY that helps teens and parents screen for common mental health problems like anxiety, depression, and conduct issues. Over 560 families in Kenya used the app to learn about mental health and connect with resources. The goal was to se…

This study tested an online program called EMPATIA designed to prevent mental health issues in teenagers who already have mild symptoms. 158 adolescents aged 12-18 used the program for 8 weeks. Researchers compared them to teens receiving usual care to see if the online intervent…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This study tested a school-based program called Fuerte for newcomer immigrant teens who have been in the U.S. for five years or less and are at risk for traumatic stress. The program aims to help teens understand mental health, build social connections, and connect those who need…

Researchers are testing a cognitive behavioral therapy program designed for autistic teens who have anxiety, depression, or both. The therapy focuses on exposure and behavioral activation, with adjustments for autism. Teens and their caregivers take part together. The trial compa…

Researchers at the University of Reading are testing an online guided-writing program for people who care for a loved one with Parkinson's disease. The program asks caregivers to complete four writing exercises that encourage them to respond to their own struggles with the same k…

This trial tests a year-long caregiver training program called MISC-CBO. The program uses video feedback to help community-based organization caseworkers improve their interactions with orphaned and vulnerable children. Researchers will compare children whose caseworkers receive …

This trial tests a web-based parent training program, called Parenting Wisely for Residential Treatment, for parents of adolescents aged 11 to 17 in psychiatric residential treatment. The program includes online modules and facilitated parent groups to prepare families for the te…

This pilot study tests a 10-session group program called AgingUP, designed for adults aged 50 and older living with severe mental illness. The program uses cognitive-behavioral and self-compassion techniques to help participants challenge negative beliefs about aging and mental i…

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was c…

This study looks at whether Tai Chi, a gentle moving meditation, can improve chronic insomnia in breast cancer survivors. About 90 women who have completed cancer treatment and have had trouble sleeping for at least 6 months will practice Tai Chi. Researchers will measure sleep q…

This study tested whether therapeutic horseback riding can improve behavior, social skills, and emotional control in 250 autistic youth who also have a mental health condition. Participants were randomly assigned to riding, barn activities without riding, or a hybrid group. Resea…

This study tests a 12-week supervised exercise program for adults with severe mental illness, such as schizophrenia, bipolar disorder, or major depression. The program combines cycling, strength training, and breathing exercises in twice-weekly sessions. Researchers will measure …

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This study tests an online psychological support program based on Acceptance and Commitment Therapy (ACT) for mothers of children with autism. The program aims to reduce parenting stress and improve mothers' mental health, which may also benefit their children's behavior. Mothers…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This study tested a 15-session program called 'Think and Cope Positively' for people with severe mental illness (like schizophrenia or bipolar disorder). The program uses techniques from cognitive behavioral therapy and positive psychology to increase positive emotions, optimism,…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This study tested a program based on Acceptance and Commitment Therapy (ACT) for 64 caregivers of people with mental disorders. The program aimed to help caregivers build psychological resilience, manage stress better, and feel less burdened. Results showed that those who took pa…

This study tested a virtual peer agent—a friendly AI that talks with teens—to see if it can help them handle stressful life events. Fifty-five teens aged 14 to 25 used the agent for 4 weeks, having conversations about emotions, coping strategies, and support. Researchers checked …

This study looked at whether pairing first-year nursing students with older student mentors can lower their stress. Starting nursing school can be tough, and the program offered guidance on time management, studying, and coping. 120 students took part, with some getting a mentor …

This study tested a resilience coaching program (PRISM) for 260 teens aged 12-17 with chronic musculoskeletal pain. The goal was to see if coaching improves daily function, reduces distress, and lessens pain compared to usual care. Participants completed surveys and coaching sess…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested an online psychological service called eClinic for young adults aged 15 to 35 in Hong Kong who have moderate to severe anxiety or depression. The eClinic offers a private, flexible online platform with therapist-guided self-learning modules. Researchers measured…

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested an internet-based cognitive behavioral therapy (CBT) program called AMTE for adolescents with anxiety and depression. Sixty teens were randomly assigned to either the online program or a control group. The goal was to see if the program could reduce symptoms of …

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study looked at whether creating personalized profiles for children with disruptive behavior disorders (like ADHD or oppositional defiant disorder) and their parents could help predict which therapy works best. Researchers tested two common treatments—child cognitive behavio…

This study tested whether an eight-session expressive arts therapy program could increase hope in 50 hospitalized adults with schizophrenia. Participants in the therapy group showed significantly higher hope scores compared to those receiving standard care alone. The findings sug…

This study tested a 10-week peer support program called 'Paths to everyday life' for adults with mental health difficulties. Participants were randomly assigned to either the peer support group plus usual services, or usual services alone. The goal was to see if the program impro…

This pilot study tested whether music therapy could improve hope, quality of life, and social functioning in 12 people with severe mental illness living in the community. Participants chose music to listen to during 12 sessions over 20 weeks, followed by a conversation with a nur…

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested whether a non-invasive brain stimulation technique called tDCS can help people with schizophrenia whose symptoms persist despite medication. 141 adults received either real or sham tDCS over 10 sessions. The goal was to see if active stimulation leads to a meani…

This study tested a 10-session dog-assisted therapy program for 60 adults with severe mental illness. The goal was to see if spending time with trained therapy dogs could help participants build positive mental health behaviors like communication and socialization. Researchers me…

This study tested whether using virtual reality (VR) for education could help hospitalized children feel more motivated and improve their mental well-being. 158 children aged 5 to 25 were randomly assigned to receive VR sessions or standard care. The goal was to see if VR could m…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This study tested a group version of a therapy program called UP-A for 15 teenagers with severe emotional disorders like anxiety and depression. The teens were treated at a day hospital in Spain. The program aimed to help them manage their emotions and reduce symptoms. Researcher…

This study tested a 6-week supervised physical activity program for university students dealing with mild-to-moderate mental health issues like stress, anxiety, or feeling isolated. Seventeen students took part in group exercise sessions including walking, aerobics, and strength …

This study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…

This study tested a 10-session art therapy program for adults with trauma-related symptoms who have difficulty with traditional talk therapy. 38 participants made artwork to process memories and emotions. Researchers measured changes in emotional expression, self-esteem, and resi…

This study tests a training program called DECIDE for MOM, designed to help healthcare providers better support pregnant and postpartum individuals with mental health concerns. The training teaches skills like shared decision-making and understanding patients' perspectives. Resea…

This study tests whether a simple team debriefing tool, called an After-Action Review, can help child welfare teams better connect children and families to mental health services. Researchers will work with 320 participants, including caseworkers and family members, to see if the…

This study tests a new approach called the Collaboration-Screening-Referral (SSH) model, which aims to identify parents involved with child welfare services who may have depression or anxiety. Social workers will be trained to use screening questionnaires and refer parents to men…

This study tested whether an AI-powered smartwatch could help teenagers and young adults with mental health conditions stick to their medication schedule. Researchers compared medication adherence in 78 people who wore the watch to those who did not. The goal was to see if the wa…

This study looks at whether spending 2 to 3.5 weeks at a device-free summer camp in Maine can improve mental health and brain activity in teens aged 12 to 17. Researchers will measure changes in mental health scores and brain waves (EEG) from the start to the end of camp. The goa…

This study explores whether two non-invasive measures—fat in the liver and thickness of the carotid artery—can serve as early warning signs of heart and metabolic problems in children treated with antipsychotic medications. Researchers will compare these measures in children on a…

This study tests an 8-week school program called INSPIRE, designed to help Indonesian teenagers aged 13-15 learn about mental health, build resilience, and reduce symptoms of depression and anxiety. Trained school counselors deliver the program using lesson plans and activities, …

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study tested a program that uses technology and trained family navigators to help children with autism and their families get connected to mental health services more quickly. The program was used in primary care clinics. Researchers measured how acceptable, feasible, and he…

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study tested a program called Naungan Kasih-Hybrid that combines a single in-person session, teacher-led WhatsApp groups, and a chatbot to help parents of preschoolers in low-income families in Malaysia. Over 770 parents and 750 children from 50 preschools took part. The goa…

This study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…

This study looked at whether digital services like smartphone apps can help people with psychosomatic disorders continue their treatment during the COVID-19 pandemic, when social distancing and hygiene rules limit in-person therapy. About 2000 patients from clinics took part, usi…

This study tested a program for people with long-COVID that includes an online screening, a detailed in-person assessment, and digital training modules with a personal counselor. 192 participants from Bavaria took part to see if this approach is practical and helpful. The goal wa…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the mental health of hospital staff and medical students after the 2016 Nice terrorist attack. Researchers surveyed 804 people to understand how the event affected them and to find better ways to support caregivers in future crises. The goal was to learn, not…

This completed study placed a full-time chaplain in a primary care clinic to see how often patients and doctors asked for spiritual or emotional support. Researchers tracked what topics patients discussed with the chaplain and tested a way for clinic staff to identify who might b…

This study looked at whether a program called MISSION-CJ can help homeless veterans who have both substance use and mental health problems stay out of trouble with the law. 134 veterans took part, and researchers tracked arrests, substance use, housing, and employment. The goal w…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study looked at how people with long-term mental disorders and their caregivers can work together to improve heart health. People with these conditions often die 20 years earlier than others, mainly from heart disease. The researchers interviewed 127 participants to understa…

This study tested whether people with hypopituitarism (a condition where the pituitary gland doesn't work properly) have lower oxytocin levels compared to healthy individuals. Researchers gave participants a drug called exenatide (a GLP1 receptor agonist) to see if it could stimu…

This study tested a program called iCOT to improve how occupational therapy interns communicate with patients in mental health settings. The program included online training and feedback from patients, supervisors, and experts. Researchers compared interns who received iCOT to da…

This study tested whether training staff in residential facilities can help prevent suicide and improve mental health for youth in the legal system. About 1000 youth and staff took part. Researchers compared facilities that received the special training to those that did not, mea…

This study followed 252 French-speaking teenagers from age 17 to 19 to understand what factors increase or decrease the risk of mental health problems. Participants completed surveys about their mental health, quality of life, and family life at the start and two years later. The…

This study interviewed 26 older adults (75+) with chronic illnesses who take many medications. Researchers wanted to understand how patients feel about being cared for by the same doctor over time, and what happens when they lose that regular doctor. The goal was to learn about t…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study tested a program where trained peer coaches (people who have their own experience with mental illness) helped 16 young adults (ages 18-30) with serious mental illness make decisions about joining community activities like work, school, or social events. The goal was to…

This study tested different parts of a family navigation program to see which ones work best for helping low-income and minority families get mental health services for their children. 312 children aged 3-12 who showed signs of behavioral health concerns took part. The goal was t…

This study used artificial intelligence to predict how engaged people would be in online therapy and how much their symptoms would improve. Researchers analyzed data from over 6,600 adults who took part in a digital psychotherapy program. The goal was to create fair and accurate …

This study tested whether teens on probation would use a meditation app called Bodhi AIM for one month. Researchers wanted to see if it was possible to collect data remotely on cannabis use, sexual health, and mental health. The study involved 107 teens aged 13-18 in Cook County,…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study looked at how to make mental health care more available in Sub-Saharan Africa. Researchers worked with 901 clinic staff in Mozambique to train local health workers and use existing community programs. The goal was to find cost-effective ways to help more people get the…

This early-stage trial tested a single dose of MSD-001 in 47 healthy adults to see if it is safe and how the body processes it. The drug is being developed as part of a future combination treatment for mental health conditions. The study is now complete.