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After the weight loss shot: can supplements save your muscle and mood?

NCT ID NCT07269821

Disease control Sponsor: University of Alicante Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether taking a daily mix of food supplements (like polyphenols and prebiotics) for 12 weeks helps people who recently lost weight with GLP-1 drugs. The goal was to see if it could improve body composition, emotional well-being, and gut health after stopping the medication. 70 adults who had lost at least 5% of their body weight took part, with half getting the supplements and half getting a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Jul 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 25 to 60 years. * Documented unintentional or pharmacologically induced weight loss of ≥5% during the previous 3 months. * Stable body weight (±2 kg variation) during the 2 weeks prior to enrollment. * Completion or discontinuation of GLP-1 receptor agonist or other pharmacological weight-loss therapy within the last 3 months. * Willingness to maintain habitual dietary and physical activity habits throughout the study. * Ability to provide written informed consent and comply with all study procedures. Exclusion Criteria: * Current or recent use (within 3 months) of antibiotics, probiotics, or prebiotic supplements. * Active gastrointestinal disorders (e.g., inflammatory bowel disease, celiac disease, chronic diarrhea, or severe constipation). * Diagnosis of diabetes mellitus, cardiovascular disease, cancer, liver, or kidney dysfunction. * Pregnancy, breastfeeding, or intention to become pregnant during the study period. * Psychiatric disorders or use of medications affecting mood or appetite. * Participation in another clinical trial during the previous 3 months. * Any condition that, in the investigator's opinion, could interfere with study participation or interpretation of results.

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Conditions

The condition(s) this trial relates to.

Body-Weight Trajectory mental disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Emotional disorder GLP - 1 Microbiota balance Weight loss trajectory

Contacts and locations

Locations

  • European Institute Of Exercise and Health

    Elche, Alicante, 03202, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.