Infertility disorder

This study looked at whether inositol, a natural supplement, can improve ovulation in women with polycystic ovary syndrome (PCOS) who did not respond to the fertility drug letrozole. 36 women aged 18-35 took part. The researchers compared inositol to metformin, another common tre…

This study compares two follicle-stimulating hormones, follitropin delta and follitropin alfa, used to stimulate the ovaries in Indonesian women under 40 undergoing intrauterine insemination (IUI) for infertility. Researchers will review medical records from a fertility center to…

This study tests whether a progesterone shot under the skin works as well as a vaginal gel for supporting early pregnancy after a frozen embryo transfer. About 688 women aged 35 to 42 with infertility will take part. The goal is to see which method leads to more successful pregna…

This trial asks whether adding sildenafil citrate to the standard fertility drug clomiphene citrate can improve ovulation and pregnancy rates in women with polycystic ovary syndrome (PCOS) who have been trying to conceive for over two years. About 98 women aged 18–45 will be rand…

This study looked at whether taking 12 mg of estradiol daily is better than 8 mg for preparing the uterus lining in women undergoing frozen embryo transfer. 850 women aged 18-40 were randomly assigned to one of the two doses. The goal was to see if the higher dose leads to more p…

This study investigates whether having a full bladder during intrauterine insemination (IUI) can improve pregnancy rates. The idea is that a full bladder straightens the uterus, making it easier to place sperm correctly using ultrasound guidance. The trial compares this approach …

This study tests a combination of herbs (Melats P) in 116 women aged 18-40 with PCOS and insulin resistance. The goal is to see if the treatment can restore regular periods and ovulation, helping overcome infertility. Participants will be monitored for 4 months using ultrasound a…

This study tested whether a two-shot hormone schedule works as well as the usual longer schedule for women freezing their eggs for non-medical reasons. 194 healthy women aged 18-40 received either two injections of corifollitropin alfa or one injection followed by daily shots of …

This study tested a herbal extract from a Himalayan plant (Nepeta adenophyta) in 116 women with PCOS. Participants took either the herb, the standard drug metformin, or both for 4 months. The goal was to see if the herb could help restore regular menstrual cycles and improve meta…

This Phase 3 trial tested whether taking Elagolix (a hormone-blocking pill) for two months before IVF could improve live birth rates in women with endometriosis. 103 women participated, and the main goal was to see if more babies were born after this pre-treatment. The study comp…

This study looked at 99 IVF patients with endometriosis (a condition where uterine-like tissue grows elsewhere) and a positive BCL6 test. It compared a cheap oral pill (norethindrone acetate) to an expensive injection (Depo Lupron) given before embryo transfer. The goal was to se…

This study tested a new ovarian stimulation protocol for IVF that aims to keep estrogen levels more natural while still producing many eggs. 129 women with good IVF prognosis participated. The goal was to see if this approach leads to more live births compared to the standard met…

This study tested whether a short course of the steroid prednisone could improve sperm quality in men with infertility caused by inflammation. Researchers measured markers of oxidative stress and sperm health six months after treatment. The trial involved 200 men and compared pre…

This study tested whether a daily supplement called TetraSOD®, made from a special marine microalgae, can improve sperm quality in men with unexplained infertility. Eighty men took either the supplement or a placebo for 90 days. The main goals were to see if sperm movement and co…

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo develop…

This study tested whether giving a small daily dose of a hormone (human menopausal gonadotropin) after egg retrieval could improve the chance of a live birth in women undergoing IVF. 600 women aged 20-40 took part. The researchers compared live birth rates between those who got t…

This study tested whether adding a diabetes drug (polyethylene glycol loxenatide) to a hormone-releasing IUD (LNG-IUS) helps women with a precancerous uterine condition called endometrial atypical hyperplasia. The 30 participants were all obese and wanted to preserve their fertil…

This study looked at whether adding vaginal estradiol or oral guaifenesin to standard fertility treatment (clomiphene citrate) could improve pregnancy rates. 90 women with infertility were randomly assigned to one of three groups. The goal was to see if these add-ons helped with …

This completed trial tested a new device called HyperSperm that prepares sperm for IVF or ICSI. Researchers compared it to standard sperm preparation in 41 couples. The goal was to see if the new method leads to more embryos reaching the blastocyst stage, which is key for success…

This study tested a microfluidic chip that gently separates healthy, motile sperm from semen without harsh chemicals. Researchers compared it to the standard spinning method in 393 couples undergoing IVF for unexplained infertility. The goal was to see if the chip leads to higher…

This study tested whether a step-up dose of the drug letrozole helps women with PCOS ovulate better than the standard low dose. 70 women took either the step-up or standard dose for up to 3 menstrual cycles. Researchers tracked follicle growth, uterine lining thickness, and pregn…

This study looked at whether giving an extra hormone (FSH) along with the usual hCG trigger before egg retrieval in IVF can improve egg quality and pregnancy rates. 232 women undergoing IVF took part. The goal was to see if this approach, which mimics a natural menstrual cycle, l…

This study looked at whether taking 162 mg of aspirin is better than 81 mg for women undergoing frozen embryo transfer. Researchers reviewed records from 1,207 women under 40 to see if the higher dose led to more pregnancies. The goal was to find a simple way to improve fertility…

This study tested whether postbiotic suppositories (containing natural bacteria byproducts) could improve the vaginal microbiome in 15 infertile women aged 30-45 who had at least two failed IVF attempts. Participants used one suppository daily for 8 weeks. Researchers measured ch…

This study tested a high dose of a fertility drug called follitropin delta, mixed with another hormone (hCG), in 118 women undergoing IVF. The goal was to see if this combination could improve the number of good-quality embryos. The study was completed and focused on women aged 1…

This study tested whether an oral probiotic supplement could help restore healthy bacteria in the vagina. It included 32 women aged 35-43 with vaginal imbalance and fertility concerns. Researchers measured how well the probiotic colonized the body and its effects on immune and an…

This study tested whether a combination of intravenous immunoglobulin (IVIg) and prednisolone can increase the chance of a live birth in women who have had two or more unexplained miscarriages after fertility treatments like IVF. Eighty women were randomly assigned to receive eit…

This study looked at whether a three-month diet and exercise program before IVF could improve live birth rates in overweight and obese women. 197 women were randomly assigned to either the weight loss group or a control group. The goal was to see if losing weight beforehand leads…

This phase 3 trial tested whether an oral tablet called SHR7280 works as well as the standard injection (ganirelix) for preventing early ovulation in women undergoing IVF. The study involved 317 infertile women aged 20-39. If effective, the pill could offer a more convenient opti…

This study tested whether an antioxidant supplement called Proxeed Plus could improve sperm motility in men with asthenozoospermia (low sperm movement), a common cause of male infertility. Thirty men took either the supplement or a placebo daily for three months. Researchers meas…

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tested an AI software called MAGENTA Blast that analyzes images of Day 3 embryos to predict which ones will develop into blastocysts by Day 5. Researchers looked at data from 76 women undergoing IVF to see if the tool could help embryologists make better decisions abou…

This completed study looked at 251 women with infertility who had a hysterosalpingography (HSG) — an X-ray test that checks if the fallopian tubes are open. The researchers compared three different ways of doing the test: using a metal cannula, an active balloon, or a passive bal…

This study looked at 160 men with azoospermia (no sperm in semen) to see if a special PET scan (FDG PET-CT) could tell which men would have sperm found during testicular extraction. The scan measures how active the testicles are. The goal was to compare scan results between men w…

Researchers are testing whether adding alpha-lipoic acid, an antioxidant supplement, to standard letrozole treatment helps infertile women with polycystic ovary syndrome ovulate and become pregnant. The trial enrolls 150 women aged 18 to 35 who are trying to conceive. Both groups…

This study tested whether a medication reminder app on smartphones helps women undergoing IVF remember to take their injections. Researchers compared 387 patients who used the app with those who did not, tracking how often they forgot doses, their satisfaction, and the number and…

This study investigates whether a 60-minute web-based education program can reduce infertility-related distress and improve fertility readiness in women undergoing intrauterine insemination (IUI) treatment. The program covers fertility basics, diagnostic methods, medications, and…

This study tested whether a special supportive care program could help couples feel less stressed and cope better during infertility treatments like IVF. Fifty couples were randomly assigned to either receive this extra emotional support or standard care. The program focused on u…

This study tested whether a simple mindfulness exercise—noticing natural changes in mood and body throughout the day—could improve wellbeing for couples dealing with infertility. 70 patients and their partners took part. The goal was to see if this low-cost, easy-to-learn approac…

This study tested whether watching a short video about how to use IVF medications could improve quality of life and reduce anxiety in women going through IVF for the first time. Sixty-two women participated, and researchers measured their distress, quality of life, and anxiety le…

This study tested whether psychological interventions can reduce anxiety in women about to undergo egg retrieval with general anesthesia. 180 women participated, with some receiving the intervention and others not. Researchers measured anxiety using a questionnaire just before th…

This study tested whether eating two ounces of walnuts each day could improve sperm count, movement, and shape in men with fertility issues. 80 men took part, comparing walnuts to a standard multivitamin. The goal was to see if a simple diet change could help with natural or assi…

This study tested whether a specific nursing care program could help women struggling with infertility feel less stressed and more supported. Eighty women undergoing fertility treatments were split into two groups: one received the special nursing program, and the other received …

This study tested whether letting women listen to their own chosen music during embryo transfer could lower anxiety and pain. 42 IVF patients were randomly assigned to either listen to music through noise-canceling headphones or receive standard care. Researchers measured anxiety…

This study tested whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people struggling with the emotional stress of infertility. Nine adults with infertility took part in 12 therapy sessions. Researchers measured changes in mood, stress, and ho…

This study tested whether taking melatonin, a natural antioxidant, can improve egg quality and pregnancy rates in women undergoing IVF. Eighty infertile women received either melatonin or a placebo. Researchers measured melatonin levels in ovarian fluid and tracked egg maturation…

This study tested whether an 8-week mindfulness-based stress reduction program could lower stress, anxiety, depression, and cortisol levels in infertile women. 84 women participated, with half taking the program and half serving as a control group. The goal was to see if mindfuln…

This study looks at whether a new pain management approach helps people going through in vitro fertilization (IVF) feel less pain. Researchers will compare pain scores from 206 patients to those from an earlier study. The goal is to see if the updated care plan reduces discomfort…

Researchers at the University of California, San Francisco, are studying how genes and environment affect the rate at which women's ovaries age. They will measure antral follicle counts by ultrasound and collect DNA from 1,080 women aged 25 to 45 with regular menstrual cycles. Th…

Researchers at the University of California, San Francisco are running a long-term study to see whether children conceived through infertility treatment have different metabolic profiles than other children. The study has two parts: one looks back at children already born, and th…

This study looks at whether doing a laser-assisted hatching procedure on Day 3 or Day 5 of embryo growth changes the genetic test results in IVF. About 200 people having IVF with genetic testing will take part. The goal is to see if timing affects embryo health and the accuracy o…

This study looked at people with low or no GnRH, a hormone that controls puberty and fertility. Researchers studied 111 adults and teens to understand how GnRH problems affect the body. The goal was to find new hormone patterns and genetic causes, not to test a treatment.

This survey follows people who use the REKOVELLE pen, which contains the hormone follitropin delta, to stimulate the ovaries during assisted reproduction like IVF or ICSI. The goal is to track how often side effects occur when the drug is used in everyday clinical practice. Resea…

Researchers are collecting images of eggs and embryos from time-lapse incubators to train an AI system called CHLOE. The goal is to see if the AI can accurately predict which embryos will reach the blastocyst stage, a key step in IVF. This study involves women aged 18 and older w…

This study tests a patient navigator program for 28 underserved people struggling with infertility. The navigator helps with insurance, appointments, and tests to speed up care. Researchers compare their progress to similar patients from the year before. The goal is to see if thi…

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This study tests whether a five-day education program, based on a health promotion model, can improve fertility awareness and preconception knowledge in women aged 18–35 who plan to get pregnant within a year. Participants attend daily 60-minute group sessions for five days. Rese…

This study looked at how two fertility hormones, FSH and hCG, are absorbed after daily injections in 28 healthy women. The goal was to understand the drug's behavior in the body, not to treat infertility directly. Results will help design better ovarian stimulation treatments for…

This study looks at two ways to examine the uterine cavity after women have had hysteroscopic surgery for conditions like polyps, fibroids, or a uterine septum. One method is a non-invasive 3D ultrasound; the other is an office hysteroscopy, which involves inserting a small camer…

This study looks at how sleep length and quality may affect the success of in vitro fertilization (IVF) in women. Participants will wear a ring-shaped device that tracks sleep patterns before and after a frozen embryo transfer. The goal is to see if sleep parameters like total sl…

This study looked at how in vitro fertilization (IVF) affects the quality of life of working women. Researchers followed 200 women starting their first IVF treatment, using questionnaires to measure emotional, social, and work-related impacts over up to 18 months. The goal was to…

This study tested a device called the Alife Hera System, which uses a computer algorithm to score embryos based on images and patient information. The goal was to see if using this score alongside standard methods helps doctors choose the embryo most likely to result in a pregnan…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looked at 112 people with known differences in their sex chromosomes (X and Y) to better understand how these variations affect health, especially infertility. Participants underwent physical exams, blood and urine tests, imaging, and sensory checks over about 5 days. …

This study tested a device called Seedchrony that measures a natural chemical in the uterus to see if it can predict whether an embryo transfer will lead to pregnancy. The study involved 92 women undergoing their first IVF cycle. The goal is to find a way to improve the low succe…

This study looked at how lifestyle factors like diet and health habits affect a couple's ability to conceive. Researchers followed 266 couples planning their first pregnancy, tracking how long it took to get pregnant and any early pregnancy losses. The goal was to better understa…

This study surveyed 385 women aged 35 or younger with early-stage breast cancer to learn their attitudes about the risk of infertility from adjuvant therapy. The goal was to understand how concerns about having children might influence their treatment choices. The results could h…

This study tested whether less invasive methods—a vaginal swab or a fluid sample from the uterus—can accurately measure the microbiome (bacteria) in the womb, compared to the standard endometrial biopsy. Fifty-seven women provided samples at two time points. The goal is to find a…

This study looked at 110 women aged 35-40 with low ovarian reserve undergoing IVF. Half received a mild stimulation (clomiphene plus low-dose hormones) and half received a stronger stimulation (higher-dose hormones). The goal was to see which approach led to more good-quality bla…

This study tested a new way to pick the healthiest embryos for IVF. Instead of the usual expensive genetic test, researchers used a machine (NMR) to analyze the fluid embryos grow in. They looked for chemical differences between normal and abnormal embryos. The goal is to make em…

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids. The goal was to see how often women later had a baby and what pregnancy complications occurred. The researchers reviewed medical records from one hospital in France to gat…

This completed study looked at 778 couples undergoing IVF to see if transferring embryos in two steps (sequential double embryo transfer) leads to more live births than the standard one-step double transfer. Researchers compared pregnancy and miscarriage rates between the two met…

This study looked at whether using frozen embryos instead of fresh ones in IVF leads to more live births. 237 women took part, and researchers compared pregnancy rates and baby health. The goal was to see if freezing embryos helps the womb lining work better.

This completed phase 1 study looked at how the fertility drug Pergoveris (a combination of two hormones, FSH and LH) is processed in the body of 24 healthy premenopausal women of Japanese or Caucasian origin. Participants took a birth control pill for about 4 weeks to suppress th…

This study looked at over 5,800 couples who had a first baby through fertility treatment at an Italian clinic. Researchers wanted to see how many came back for more treatment to have a second or third child, and what factors—like age or frozen embryos—affected that decision. The …

This study looked at whether the level of thyroid-stimulating hormone (TSH) in the blood affects the success of a fertility treatment called ICSI. Researchers measured TSH in 180 women on day 2-3 of their menstrual cycle and then tracked egg retrieval, fertilization, and pregnanc…

This study looked at over 1,800 frozen embryo transfer cycles to see if a woman's body mass index (BMI) affects whether the transfer can be done as planned and if it leads to pregnancy. Researchers compared obese and non-obese women using different hormone preparation methods. Th…

This study looked at 148 infertile women with an overactive immune system in the uterus who were undergoing IVF. Some women had a test to see if they would respond to steroid treatment before embryo transfer, while others did not. The goal was to see if the test helped improve th…

This study looked at 400 couples to understand how diet, lifestyle habits like smoking and exercise, and genetics influence fertility. Researchers compared fertile and infertile couples to find nutritional factors that may help or hinder conception. No treatment was given; the go…

This study compared two advanced embryo culture systems used in IVF with ICSI. One system has a built-in camera to watch embryos continuously, while the other uses periodic microscope checks. Researchers wanted to see if either system leads to more embryos implanting successfully…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods for IVF. Researchers looked at data from 333 people who had IVF between 2022 and 2023. The goal was to see if the AI's scores matched up with expert embryolo…

This study looked at whether genetic material released by embryos into their growth fluid can be used for genetic testing, instead of taking a cell sample (biopsy). Researchers analyzed fluid from about 200 donated embryos and compared results with biopsies from the inner and out…

This study looked at whether using a special freezing medium designed just for eggs, versus a universal medium for all stages, affects pregnancy rates in egg donation. Researchers analyzed data from 111 donor cycles. The goal is to see if the type of freezing medium makes a diffe…

This study looked at how a single injection of Gonadotropins-IBSA, a fertility drug, is processed by the body. It involved 29 healthy women of childbearing age. The goal was to measure hormone levels and check for side effects, not to treat infertility directly.

This completed observational study looked at 150 women to see how different types of fibroid removal surgery (hysteroscopic, laparoscopic, or laparotomic) affect pregnancy outcomes. It compared women who had surgery with those who did not, and also looked at whether surgery durin…

This study compared a low-cost, low-intensity egg freezing protocol (fewer doctor visits and injections) to the standard high-intensity approach. Researchers looked at how many eggs were retrieved, patient satisfaction, and overall cost. The goal is to see if a simpler, cheaper m…

This study tested a new way to select sperm for IVF. Instead of an embryologist picking the best-looking sperm, they used sperm that naturally attached to the outer layer of an immature egg. The goal was to see if this method leads to more embryos developing into blastocysts. The…

This study looked at tiny molecules in the blood called miRNAs to see if they could help doctors tell apart two similar conditions in boys: undescended testicles (which need surgery) and retractile testicles (which usually get better on their own). Researchers took blood samples …

This study looked at over 1,200 women under 40 who had a frozen embryo transfer. Some used a natural cycle with no hormones, while others took estrogen and progesterone to mimic a natural cycle. The goal was to see which method leads to more pregnancies. Results could help clinic…

This study looked at 158 women having intrauterine insemination (IUI) to see if progesterone levels on the day of insemination are linked to pregnancy rates. IUI is a simpler, cheaper fertility treatment than IVF, but success rates are low. Researchers measured progesterone and o…

This study looked at whether testing the fluid around embryos (non-invasive chromosome screening, or NICS) can help doctors choose the best embryo for IVF. Over 1,100 couples took part, with women aged 35-42. The goal was to see if adding NICS to standard visual checks leads to m…

This study tested a robotic assistant to automate key steps in the IVF lab, such as preparing sperm and eggs, injecting sperm into eggs (ICSI), and freezing embryos. Researchers compared the robot's performance to standard manual methods using eggs and embryos from 42 couples und…

This study observed 201 women in Nordic countries and Switzerland who were using the fertility drug REKOVELLE® for the first time during IVF or ICSI. Researchers tracked how doctors prescribed the drug, including dose adjustments and use of a dosing app, to understand real-world …

This study looked at whether flushing the uterus with a low dose of the hormone hCG right after egg retrieval could improve pregnancy rates in women undergoing IVF. Researchers measured immune markers and blood flow in the uterus to see if the flush made the womb more receptive t…

This study followed 214 children born from two different fertility treatments—CAPA-IVM and conventional IVF—to see if their development and behavior at age 5 were similar. Researchers used parent questionnaires to assess communication, motor skills, problem-solving, and emotional…

This study looked at 87 women who had no eggs retrieved during their first IVF cycle. Researchers wanted to see if a second round of ovulation-inducing medication could lead to successful egg retrieval. The goal was to understand which factors might predict failure and how to imp…

This study looked at how common migraines are in infertile women and how they change during IVF treatment. Researchers gave 137 women a simple questionnaire to track headaches and medical history. The goal was to understand if the hormone changes from IVF can trigger or worsen mi…

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg supply. Researchers measured a hormone called AMH in blood samples from over 800 women with MS or a related condition. The goal was to see if disease activity or medications impact ovaria…

This study looked at genes in cumulus cells (cells that surround eggs) from 137 women undergoing IVF. The goal was to find genetic markers that predict which embryos are most likely to lead to a pregnancy. Researchers compared two different hormone treatments to see if gene patte…