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Fertility boost? study tests estradiol and guaifenesin alongside clomiphene

NCT ID NCT07398924

Disease control Sponsor: Yuzuncu Yil University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding vaginal estradiol or oral guaifenesin to standard fertility treatment (clomiphene citrate) could improve pregnancy rates. 90 women with infertility were randomly assigned to one of three groups. The goal was to see if these add-ons helped with uterine lining and cervical mucus, which can be affected by clomiphene.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Jan 2022

Finished

Jun 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Women aged 18 to 40 years * Diagnosis of infertility * Indication for ovulation induction with clomiphene citrate * Regular or irregular menstrual cycles suitable for ovulation induction * At least one patent fallopian tube * Normal uterine cavity on ultrasonography * Male partner with normal or mildly abnormal semen parameters * Willingness to participate and provide informed consent Exclusion Criteria: * \- Known hypersensitivity to clomiphene citrate, guaifenesin, or estradiol * Severe male factor infertility * Presence of uterine anomalies or intrauterine pathology * Endocrine disorders affecting ovulation (e.g., uncontrolled thyroid disease, hyperprolactinemia) * Polycystic ovary syndrome requiring alternative stimulation protocols * History of recurrent pregnancy loss * Use of hormonal treatment within the last 3 months

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Conditions

The condition(s) this trial relates to.

anovulation female infertility infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anovulatory infertility Female infertility Unexplained infertility

Contacts and locations

Locations

  • Van Yuzuncu Yil University Dursun Odabasi Medical Center

    Van, Di̇yarbakir, 21640, Turkey (Türkiye)

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