Could a vaginal postbiotic boost IVF success?
NCT ID NCT07278024
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether postbiotic suppositories (containing natural bacteria byproducts) could improve the vaginal microbiome in 15 infertile women aged 30-45 who had at least two failed IVF attempts. Participants used one suppository daily for 8 weeks. Researchers measured changes in vaginal bacteria and pregnancy rates in a subsequent IVF cycle. The study is small and has no control group, so results are preliminary.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- postbiotic bacteriocin suppositories
- What this could lead to
- If it works, this could point toward a simple way to improve pregnancy chances in women with repeated IVF failures.
- What could go wrong
- This is a very small, early study with only 15 people and no comparison group. Results may not apply to others, and the treatment might not improve pregnancy rates.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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15 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * (1) age 30-45 years; * (2) body mass index 18-30 kg/m²; * (3) history of ≥2 prior IVF treatment failures despite transfer of good-quality embryos; * (4) planned FET cycle; * (5) willingness to comply with the eight-week postbiotic intervention protocol Exclusion Criteria: * (1) active acute vaginal infection with symptomatic presentation; * (2) antibiotic or probiotic use within the preceding three months; * (3) congenital uterine anomalies including septate, bicornuate, or unicornuate uterus; * (4) severe intrauterine adhesions (Asherman syndrome grade III-IV); * (5) history of gynecologic malignancy; * (6) known allergy or hypersensitivity to Lactobacillus-derived products; * (7) current ongoing pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Kaohsiung City, Taiwan
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