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IVF breakthrough? new study tests fluid instead of embryo cells for genetic checks

NCT ID NCT06780605

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether genetic material released by embryos into their growth fluid can be used for genetic testing, instead of taking a cell sample (biopsy). Researchers analyzed fluid from about 200 donated embryos and compared results with biopsies from the inner and outer cell layers. The goal is to make embryo genetic testing safer and less invasive for IVF patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a non-invasive genetic test for embryos, reducing the need for risky biopsies during IVF.
What could go wrong
This is a small, completed observational study, not a treatment trial. The method may not be accurate enough to replace biopsies in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

230 people

The number who actually took part.

Started

Oct 2024

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Donated embryos to research from patients undergoing IVF/ICSI or PGT-A cycles will be eligible for the study after informed consent signature.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Study informed consent form, approved by the Ethics Committee, signed. * Any patient with aneuploid or euploid blastocysts from PGT-A cycles donated for research. * Patients undergoing regular IVF/ICSI cycles aiming to donate surplus embryos for research. * Embryos from own or donated oocytes can be included. * Embryos fertilized with donated sperm can be included. * Only blastocysts with proper re-expansion and good quality after thawing will be included. Exclusion Criteria: * Blastocysts that had not survived to vitrification, that had not re-expanded properly or having poor ICM or TE quality. Note: No exclusion criteria specific to the patients' background will be considered.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • British Cyprus IVF Hospital

    Nicosia, 2681, Cyprus

  • Ventus IVF Center

    Nicosia, 99010, Cyprus

More trials for these conditions

Other studies related to the condition(s) this trial covers.