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Fertility follow-up: what drives couples to try for a second child?

NCT ID NCT07458165

Knowledge-focused Sponsor: Istituto Clinico Humanitas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at over 5,800 couples who had a first baby through fertility treatment at an Italian clinic. Researchers wanted to see how many came back for more treatment to have a second or third child, and what factors—like age or frozen embryos—affected that decision. The goal is to better understand family-building patterns after assisted reproduction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

5,852 people

The number who actually took part.

Started

Jan 2010

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study included all couples who underwent and completed ART cycles and achieved a first live birth between January 2010 and December 2020, who subsequently returned for new attempts, and met the following inclusion criteria: being a heterosexual couple with maternal age between 18 and 43 years, having complete clinical and demographic data available in the internal database, and having follow-up information up to December 2024

Ages

18 to 43 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Copules underwent ART treatment at the Humanitas Fertility Center (Rozzano, Milan) * Copules achieved a first clinical pregnancy resulting from ART between January 2010 and December 2020 * heterosexual couples in which the maternal age was between 18 and 43 years old Exclusion Criteria: * Couples who did not meet the inclusion criteria * ART cycles involving preimplantation genetic testing for aneuploidy (PGT-A) * Use of donor gametes (oocyte or sperm donation)

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility assisted reproductive technology

More trials for these conditions

Other studies related to the condition(s) this trial covers.