Fibromyalgia

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) works better than standard medications (Cymbalta or Lyrica) for fibromyalgia triggered by emotional trauma. 48 adults completed the trial, and researchers measured symptom improve…

Pregnancy can worsen fibromyalgia symptoms like pain, fatigue, and poor sleep, affecting both mother and baby. This trial tests a community-based nursing program that combines weekly education sessions with twice-weekly exercise, including prenatal yoga and stretching, for pregna…

Researchers are testing whether a stretching exercise program supervised over video call can improve pain, depression, sleep, and daily function in women with fibromyalgia. The trial enrolls 28 women aged 30 to 60 in southern Brazil. Half join live stretching sessions twice a wee…

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

This study looked at whether an antidepressant, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative feelings. About 308 adults aged 18-75 with pain lasting over 6 months took part. The goal was to see if these trea…

This study tests whether a virtual program called Lin Health can improve daily life for people with fibromyalgia. Researchers at Mayo Clinic will follow 300 adults with fibromyalgia to see if online behavioral health support reduces symptoms and improves function. The goal is to …

This trial compares two non-drug treatments for myofascial pelvic pain syndrome in women: precise AI-controlled radiofrequency therapy versus biofeedback combined with electrical stimulation. Researchers will randomly assign 70 women to one of the two treatments and measure chang…

This trial tests a two-month interdisciplinary program for adults with fibromyalgia, combining adapted aerobic exercise, online education about pain, cognitive-behavioral and mindfulness counseling, and personalized nutritional advice. The goal is to see if this holistic approach…

This study tests a 12-week home program that combines AI-guided exercises with pain education for adults with fibromyalgia. Half of the 50 participants will use the digital program, while the other half receives usual care. The goal is to see if this approach reduces pain and imp…

This trial tests whether TECAR therapy, a non-invasive device that delivers energy to painful areas, can reduce pain in people with fibromyalgia. About 46 adults with fibromyalgia will receive either real or sham TECAR sessions twice a week for three weeks. Researchers will measu…

This study tests whether a noninvasive device that stimulates the vagus nerve can reduce pain and other symptoms in women with fibromyalgia. Participants will receive either the nerve stimulation, standard medical treatment, or both, to see which approach works best. The goal is …

This trial tests whether taking magnesium can reduce stress in people with fibromyalgia, a condition marked by widespread pain and fatigue. Participants will be randomly assigned to receive magnesium or a placebo, and researchers will measure stress levels along with pain, sleep,…

This trial tests whether high-intensity or preferred-intensity resistance training better improves quality of life in women with fibromyalgia. Participants will complete 16 supervised sessions of each type, with a washout period in between. Researchers will measure disease impact…

This trial tests whether daily creatine supplements can reduce pain, fatigue, and muscle weakness in people with fibromyalgia. Eighty adults diagnosed with fibromyalgia will receive either creatine or a placebo for a set period. Researchers will measure changes in pain levels, mu…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This study looks at whether joining a private social media group with others who have fibromyalgia can improve feelings of loneliness, hopelessness, and overall well-being. Researchers analyzed data from over 1,000 adults with fibromyalgia who participated in an online support co…

This study investigates whether Tongluo Kaibi Tablets, a traditional Chinese herbal medicine, can reduce pain and improve quality of life in people with fibromyalgia syndrome. The trial enrolls 150 adults aged 18 to 75 who meet fibromyalgia criteria and have significant pain. Par…

This study tested whether doing exercise in a virtual reality headset can improve quality of life, thinking, and mood in people with fibromyalgia. Thirty adults with fibromyalgia took part in a crossover trial where everyone tried both virtual reality exercise and regular exercis…

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This Phase IIa trial tests whether a new drug called ONO-1110 can safely reduce pain in people with fibromyalgia. About 160 Japanese adults will take either the drug or a placebo once daily for 8 weeks. Researchers will measure changes in pain scores and watch for side effects.

This study tested whether sound therapy using weighted tuning forks, combined with relaxation, could reduce pain in women with fibromyalgia. Forty women aged 30 to 60 took part, attending three weekly sessions. Researchers compared pain levels before and after sessions between th…

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce pain, fatigue, and mood problems while improving walking in adults with fibromyalgia. Participants receive either real rTMS or a sham version to se…

This study tested a 16-session web-based resistance training program for people with fibromyalgia. Researchers measured balance, muscle performance, and symptoms in 13 adults. The goal was to see if a home-based exercise program could improve physical function and ease fibromyalg…

This study tested a 24-session program for 100 adults with fibromyalgia. The program brings together nurses, doctors, physiotherapists, nutritionists, and mental health experts to teach self-management skills. Researchers measured quality of life, pain impact, and mood over 12 mo…

This study looked at whether adding a gentle electrical nerve stimulation (TENS) to cognitive behavior therapy (CBT) and standard medicines could reduce pain and improve quality of life in 60 postmenopausal women with fibromyalgia. Participants were split into three groups: one r…

This study looked at how the brain processes pain in people with fibromyalgia compared to healthy individuals. Researchers tested whether a non-invasive procedure called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, could reduce pain …

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study looked at whether classical massage can reduce pain and improve daily function in people with myofascial pain syndrome, a condition that causes muscle knots and radiating pain. Sixty adults aged 30–50 with active trigger points in the upper back took part. Researchers …

This study looked at whether aerobic dance exercises can improve symptoms and quality of life in women with fibromyalgia. Forty-four women were split into two groups: one did aerobic dance sessions led by a physiotherapist, and the other did standard postural exercises. Researche…

This study tested whether a daily probiotic supplement could reduce pain, fatigue, and cognitive issues in women with fibromyalgia. 97 participants took either a multi-strain probiotic or a placebo for 12 weeks. Researchers measured changes in pain, sleep, mood, and quality of li…

This study tested whether stimulating a nerve in the ear (taVNS) can help people with fibromyalgia feel better and exercise more. 90 adults with fibromyalgia were split into three groups: one-sided stimulation, both ears, or just a home exercise program. Over two weeks, researche…

This study tested whether a digital sleep therapy program called Sleepio can improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. Researchers measured changes in symptoms …

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could reduce pain and improve quality of life in people with fibromyalgia, compared to standard medications like Cymbalta or Lyrica. Seventy-six adults with fibromyalgia and a his…

This completed study tested whether hyperbaric oxygen therapy (HBOT) combined with creative art psychotherapy can help women with fibromyalgia who have a history of psychological trauma. Thirty women received 60 sessions of HBOT plus psychotherapy. Researchers measured pain sensi…

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This study tested whether a slow, gentle back massage can help women with fibromyalgia feel less pain and fatigue. 48 women took part, receiving 30-minute massages three times a week. The goal was to see if this simple, drug-free approach could improve daily comfort.

This study looked at whether indoor physical activity can improve symptoms in people with both fibromyalgia and irritable bowel syndrome (IBS). Researchers measured changes in gut and pain symptoms, intestinal health, and psychological well-being in 165 participants. The goal was…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether adding a gentle manual therapy called strain counterstrain to standard physiotherapy helps women with fibromyalgia feel better. 105 women were split into three groups: one got standard care, another got standard care plus the therapy, and a control group…

This study tested an 8-week online mindfulness-based stress reduction program in 94 adults with fibromyalgia. Participants were randomly assigned to the online program or usual care. The goal was to see if the program could reduce pain catastrophizing and improve daily function.

This study tested a self-management program for jaw muscle pain in 107 adults with fibromyalgia. The program included online sessions on pain education, jaw exercises, and self-massage. Researchers measured changes in quality of life, pain, and fear of movement over 12 months. Th…

This study tested whether different types of sounds (natural, city, broadband, or silence) can help improve mood, stress, and anxiety in people with fibromyalgia. 72 adults with fibromyalgia listened to each sound for 20 minutes during four weekly visits. Researchers measured cha…

This study looked at how intravenous lidocaine affects sleep and quality of life in 51 people with fibromyalgia who still had pain and sleep problems despite other treatments. Researchers measured pain, sleep quality, and overall impact of the condition. The goal was to see if th…

This study looked at whether an 8-week foot exercise program could help people with fibromyalgia who have foot pain. 27 adults with fibromyalgia took part. The program focused on strengthening the small muscles in the feet. Researchers measured changes in foot pain, function, and…

This completed pilot study tested whether a smartphone app teaching mindfulness could help people with fibromyalgia. Fifty-four adults used the app daily for pain tracking and weekly for mindfulness lessons, while a control group only tracked symptoms. The goal was to see if the …

This study tested whether adding home-based posture exercises to regular medication could improve pain and mobility in 55 adults with fibromyalgia. Participants did exercises at home while continuing their usual drugs. Researchers measured pain threshold, spinal flexibility, anxi…

This study tested a smartphone app designed to help people with fibromyalgia manage their condition. Researchers wanted to see if the app was easy to use and helpful. The study included 36 adults with fibromyalgia who used the app to track their symptoms and learn coping strategi…

This study tested a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve, which helps control pain and stress. Thirty adults with fibromyalgia received either real or sham stimulation for 30 minutes daily, five days a week, over four weeks…

This study tested whether an ultrasound-guided nerve block injection (stellate ganglion block) could help people with fibromyalgia who still have symptoms despite taking duloxetine. 68 adults received either the active injection or a sham (fake) injection, and researchers measure…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain in women with fibromyalgia. 100 women received either real or sham (fake) stimulation to see if the placebo effect plays a role. The goal is to find out who might benefit most from th…

This completed study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain and improve daily function in 100 women with fibromyalgia. Researchers also looked at how a person's tendency to respond to placebo might affect results. Participants receiv…

This study looked at whether 8 weeks of strength training could improve balance, muscle performance, and symptoms in 57 adults with fibromyalgia. Participants did 16 sessions of 50-minute strength exercises twice a week. Researchers measured balance, jumping ability, and upper bo…

This study tested whether adding a gentle brain stimulation technique called rTMS to standard exercise therapy could reduce pain in people with fibromyalgia. Forty-two adults with long-term pain took part, receiving either real or fake rTMS alongside exercise for 14 weeks. Resear…

This study tested whether combining a gentle brain stimulation technique called tDCS with aerobic exercise could improve the body's natural pain control system in people with fibromyalgia. 116 adults with fibromyalgia received either active or sham tDCS along with exercise or a c…

This study tested whether Pilates or core stability exercises better ease fibromyalgia symptoms like pain and balance. Thirty women aged 35-65 with fibromyalgia took part. Researchers used objective tests (pain sensitivity, balance) instead of just questionnaires to compare the t…

This study tested whether relaxation therapy can reduce chronic pain and improve daily life in people with fibromyalgia. Eighty adults with fibromyalgia were randomly assigned to either active relaxation sessions with a therapist or to relax alone in a quiet room (placebo) for 12…

This study tested whether different types of sounds—like birdsong, traffic noise, or white noise—can reduce pain in people with fibromyalgia, a condition causing widespread pain. 88 adults with fibromyalgia listened to four different sound environments for 20 minutes each, one we…

This study tested whether adding virtual reality to standard physiotherapy could help teenagers with chronic musculoskeletal pain. 34 teens aged 10-17 took part in up to 8 sessions over 6-12 weeks. The goal was to see if VR was practical and enjoyable, and whether it could improv…

This study tested whether a daily pill called ASP8062 can reduce pain and improve daily life for people with fibromyalgia. 183 adults took either the drug or a placebo for 8 weeks. Researchers measured pain scores, side effects, and overall well-being. The trial is now complete, …

This study looked at whether adding a TENS device (which uses mild electrical pulses) to regular physical therapy helps reduce pain during movement in people with fibromyalgia. Over 450 adults with fibromyalgia took part. Researchers measured pain levels and other symptoms to see…

This study tested a 12-week home exercise program for women with fibromyalgia. Sixty participants were randomly assigned to exercise or a control group. Researchers measured changes in pain, fatigue, quality of life, and mood. The goal was to see if a structured, at-home routine …

This study tested whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in women with fibromyalgia. 131 women with both conditions received either CBT-I or sleep hygiene education. Researchers measured sleep quality, pain sensitivity, and bra…

This study tested a new approach for chronic low-back pain and fibromyalgia in 48 adults. Participants received pain education plus propranolol (a blood pressure drug) to help the brain 'relearn' and reduce pain. The goal was to see if the treatment is feasible and acceptable, an…

This study tested whether phone calls from a nurse could help people with fibromyalgia feel less pain and be more active. 44 adults were split into two groups: one got standard care, the other also received an educational booklet and three phone calls over 4 weeks covering exerci…

This study tested whether a special suit called EXOPULSE Mollii can help adults with fibromyalgia feel less pain, fatigue, and depression. Twenty-eight participants wore either the active suit or a sham (fake) suit for two weeks, then had a washout period. After that, everyone co…

This study looked at whether 6 weeks of osteopathic treatment (gentle hands-on manipulation) could reduce pain in people with fibromyalgia. 101 adults with long-term fibromyalgia took part, comparing real osteopathy sessions to fake ones. The main goal was to track pain levels we…

This completed study tested whether adding cognitive behavior therapy (CBT) to standard physiotherapy helps adults with fibromyalgia feel less pain and have a better quality of life. 66 people took part, with one group doing gentle exercises and the other doing exercises plus CBT…

This study looks at how motivation to exercise relates to quality of life in people with fibromyalgia. Researchers will survey 105 adults with fibromyalgia to understand what encourages or discourages physical activity. The goal is to identify factors that could help improve exer…

This study looks at whether women with fibromyalgia are more likely to have orthorexia nervosa—an unhealthy obsession with eating only healthy foods—compared to women without the condition. Researchers will also examine how body image, anxiety, depression, and pain levels relate …

This study looks at how often sleep disorders—like poor sleep quality, sleep apnea, and restless legs syndrome—occur in people with fibromyalgia. Researchers will use questionnaires to screen patients in specialized pain clinics across France. They will also ask doctors how they …

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study investigates whether genetic differences and altered pain processing contribute to fibromyalgia, a condition marked by widespread pain and increased sensitivity to painful stimuli. Researchers will compare 260 adults with fibromyalgia to a matched control group, measur…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study aims to understand why people experience pain differently and whether the body's natural ability to manage pain can be improved through training, similar to athletic performance. Researchers will enroll 180 adults, including those with widespread muscle pain and those …

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This completed pilot study looked at how lifestyle factors like diet, physical activity, sleep, stress, smoking, and alcohol use relate to pain sensitivity in 20 women with fibromyalgia. Participants wore a Fitbit, logged food, completed questionnaires, and had pain sensitivity t…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This completed study examined whether fibromyalgia, a condition causing widespread pain, is linked to changes in eye blood vessels. Researchers compared 80 people with and without fibromyalgia using eye scans and symptom questionnaires. The goal was to see if nerve system problem…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This study looked at whether people with fibromyalgia have early, hidden changes in heart function. Researchers used a special ultrasound technique called Global Longitudinal Strain (GLS) to measure heart muscle movement in 59 fibromyalgia patients and 59 healthy volunteers. The …

This study looked at 420 people aged 80 and older to find out how many have fibromyalgia, a condition that causes widespread pain and fatigue. Researchers used standard medical criteria to diagnose fibromyalgia and also checked participants' memory, thinking, and overall health. …

This completed study looked at how psychological resilience and body image relate to pain in people with rheumatoid arthritis or fibromyalgia, compared to healthy volunteers. Researchers measured these factors using questionnaires in 124 adults. The goal was to better understand …

This completed study looked at 128 women to see if those with fibromyalgia also have more chronic pelvic pain and pelvic floor problems. Researchers used pain questionnaires to compare the two groups. The goal was to better understand how these conditions might be related, not to…

This completed study looked at blood samples from 66 women to find differences in small molecules (metabolites) between those with fibromyalgia, those with both fibromyalgia and possible sarcopenia (muscle loss), and healthy women. The goal was to identify potential biomarkers th…

This completed study from Turkey examined vitamin B12 and folic acid levels in 104 fibromyalgia patients before and after they started antiepileptic treatment. Researchers wanted to see if these drugs, already known to lower B12 and folate in epilepsy patients, have the same effe…

This completed study looked at 164 women with and without fibromyalgia to see if certain autoantibodies are linked to more severe symptoms. Researchers compared patients with high and low antibody levels, and healthy controls, using questionnaires, blood tests, skin biopsies, and…

This study aimed to uncover what factors most affect functional capacity—like walking, standing, and daily tasks—in people with fibromyalgia. Researchers assessed 42 adults using physical tests, pain and fatigue scales, posture analysis, sleep quality, and psychological questionn…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This study looked at 173 adults with fibromyalgia to see if doomscrolling—constantly reading negative news online—and social media addiction are linked to worse symptoms. Participants completed surveys about their social media habits, fear of missing out, and fibromyalgia-related…

This study tested whether problems with brain cells that control movement cause fatigue in fibromyalgia. Researchers compared 37 women (some with fibromyalgia, some healthy) by measuring muscle signals during foot exercises, including when they were cheered on. The goal was to se…

This study looks at how the brains of fibromyalgia patients and their acupuncturists work together during electroacupuncture treatment. Using special MRI scans that record both people at once, researchers hope to see if matching brain activity leads to better pain relief. The goa…

This study looked at how different types of touch, like those used in massage, affect pain in people with fibromyalgia compared to healthy volunteers. Researchers measured pain levels, touch pleasantness, and other factors like mood and trauma history. The goal was to better unde…

This study looked at whether a Turkish questionnaire about posture habits and awareness is a valid and reliable tool for people with fibromyalgia. One hundred patients completed the scale along with other surveys. The goal was to see if the scale accurately measures what it is su…

This study looked at how focusing on negative thoughts (rumination) versus distracting yourself affects your mood after physical activity in people with fibromyalgia. 47 adults with fibromyalgia took part. Researchers gave them instructions to either ruminate on their muscle tens…

This study looked at how repetitive negative thinking (rumination) affects the emotional and mental symptoms of fibromyalgia. Researchers studied 107 adults with fibromyalgia using questionnaires. The goal was to understand if rumination plays a role in depression and anxiety oft…

This study looked at how stress changes gene activity in women with chronic widespread pain (fibromyalgia). Researchers compared 84 women with and without the condition, using mental stress tests and relaxation breathing. They measured changes in DNA methylation, a process that c…