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Could fibromyalgia drugs drain your B12?

NCT ID NCT07013305

Knowledge-focused Sponsor: Gaziosmanpasa Research and Education Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from Turkey examined vitamin B12 and folic acid levels in 104 fibromyalgia patients before and after they started antiepileptic treatment. Researchers wanted to see if these drugs, already known to lower B12 and folate in epilepsy patients, have the same effect in fibromyalgia. The study is retrospective, meaning it looked at past medical records, so it can suggest a link but not prove it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antiepileptic drugs (anticonvulsants)
What this could lead to
If it shows that antiepileptics lower B12 or folate, it could point to a need for vitamin monitoring or supplementation in fibromyalgia patients.
What could go wrong
This is a small, retrospective study that only looks back at existing records. It cannot prove cause and effect, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

104 people

The number who actually took part.

Started

Jun 2025

Finished

Jul 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who were followed up for 6 months in the physical medicine and rehabilitation clinic with a diagnosis of fibromyalgia and who used antiepileptic (anticonvulsant) drugs will be retrospectively evaluated for the 6 months period (June-December 2024) before the ethics committee approval was obtained. Blood vitamin B12 and folate (folic acid) levels of the patients before and after antiepileptic drug use will be determined. Patients will be evaluated whether there is a change in vitamin B12 and folic acid levels depending on drug use.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-75 years who have been diagnosed with fibromyalgia, whose vitamin B12 and folic acid levels have been analysed, who do not receive vitamin B12 and folic acid treatment, and who do not have diabetes mellitus, liver and kidney failure Exclusion Criteria: * Patients receiving vitamin B12 and folic acid therapy at the time of antiepileptic (anticonvulsant) drugs initiation, patients with hepatic and renal insufficiency

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Conditions

The condition(s) this trial relates to.

fibromyalgia Folic Acid Deficiency folic acid deficiency anemia vitamin B12 deficiency vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fibromyalgia (FM) Folic acid deficiency Vitamin B 12 deficiency

Contacts and locations

Locations

  • Gaziosmanpasa Research and Education Hospital

    Istanbul, Gaziosmanpasa, 34255, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.