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Can you train your body to handle pain better? new study investigates

NCT ID NCT04441619

Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study aims to understand why people experience pain differently and whether the body's natural ability to manage pain can be improved through training, similar to athletic performance. Researchers will enroll 180 adults, including those with widespread muscle pain and those without pain, who will perform a fatiguing arm exercise. The study measures pain intensity and sensory responses to see if pain modulation can be enhanced.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fatiguing exercise protocol for the upper extremity (biceps muscles)
What this could lead to
If successful, this could point toward new ways to train the body's natural pain management system, potentially helping people with chronic muscle pain.
What could go wrong
This is an early-stage observational and behavioral study, not a treatment trial. Results may not lead to a direct therapy, and individual responses to exercise can vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

128 people

The number who actually took part.

Started

Nov 2020

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Asymptomatic people (ie no current pain conditions) * Participants with widespread muscle pain (WMP) aged 18 years of age and older * Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain * The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM) Exclusion Criteria: 1. Participation in a conditioning program specific to the biceps in the past 6 months 2. Any report of wrist/hand, elbow, or shoulder pain in the last 3 months 3. Any chronic medical conditions that may affect pain perception (e.g., diabetes, high blood pressure), kidney dysfunction, muscle damage, or major psychiatric disorder 4. Use of any intervention (including but not limited to medication, massage, and stretching) for symptoms induced by pain training for the duration of the study 5. Positive result on pre-MRI metal screening or pregnancy test due to contraindication for the MRI environment. 6. Any participant with ferromagnetic metal in the head, neck, or abdominal cavity

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Conditions

The condition(s) this trial relates to.

fibromyalgia Musculoskeletal Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Musculoskeletal pain

Contacts and locations

Locations

  • Unversity of Florida

    Gainesville, Florida, 32611, United States

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