Sun Yat-sen University

This study is testing whether a combination of three drugs (polatuzumab vedotin, rituximab, and chidamide) is safe and effective for elderly patients with a specific aggressive type of lymphoma who haven't had treatment before. The first part of the study will determine the safes…

This study aims to find out if using two antiviral drugs together works better than using one drug alone for people with advanced liver cancer caused by hepatitis B. Researchers will compare how long 120 patients live after starting cancer immunotherapy, depending on which antivi…

This study tests whether briefly restricting blood flow to an arm one day before kidney cancer surgery helps protect the remaining kidney tissue from injury. Researchers will compare kidney function in 174 patients who either receive this brief 'preconditioning' or proceed direct…

This study is testing whether a minimally invasive procedure to repair a leaky heart valve (mitral regurgitation) can help patients with moderate or stress-induced severe leaks stay out of the hospital. Researchers will compare the procedure plus standard medications against medi…

This study is testing whether a combination of three types of drugs can help shrink tumors before surgery in people with high-risk or borderline operable pancreatic cancer. The treatment includes a targeted drug (surufatinib), an immunotherapy drug (toripalimab), and a standard c…

This study is testing if a shorter treatment schedule with the immunotherapy drug tislelizumab, combined with standard chemotherapy and radiation, works as well as the standard, longer schedule for people with advanced nasopharyngeal cancer. It will involve about 418 adults to se…

This study aims to see if combining two platelet-boosting drugs works better than one alone for cancer patients whose treatments have caused dangerously low platelet counts. It will enroll 204 patients with solid tumors and randomly assign them to receive either the combination o…

This study is testing whether adding a drug called entinostat to standard fulvestrant therapy can help control advanced breast cancer that has started growing again after previous hormone-based treatments. It will enroll about 50 women to see if this combination can delay cancer …

This study aims to see if a new treatment approach improves survival for people with advanced oral or throat cancer. It tests whether giving a short, intense course of radiation (SBRT) combined with chemotherapy and immunotherapy *before* surgery works better than the current sta…

This study is for people with advanced head and neck cancer that hasn't spread. It compares two short drug treatments given before surgery to see which one is better at keeping the cancer from coming back. Patients will get either an immunotherapy drug alone or that same drug plu…

This study is testing if adding the anti-inflammatory drug celecoxib to the standard chemotherapy regimen (R-CHOP) works better for patients newly diagnosed with an aggressive form of lymphoma called CD5-positive DLBCL. It will involve 60 patients who will be randomly assigned to…

This study is testing whether adding the drug anlotinib to the current standard treatment (immunotherapy plus chemotherapy and radiation) works better for people with high-risk, locally advanced nasopharyngeal cancer. It will enroll 412 adults to compare the two treatment approac…

This study is testing whether a new drug called sacituzumab tirumotecan can help control advanced thymic cancer in patients whose disease has continued to grow despite receiving at least one prior treatment. The trial will enroll 38 adults to receive the drug by IV every two week…

This study is for people with a type of esophageal cancer who have just finished standard chemoradiation treatment. It tests whether taking two drugs (toripalimab and capecitabine) for a longer period as 'maintenance therapy' can help keep the cancer from growing back and help pa…

This study aims to test the effectiveness and safety of a new drug combination called goselasib for people with a specific type of advanced lung cancer (KRAS G12C mutation) who have not yet received treatment for their advanced disease. It will enroll about 69 adults to see how w…

This study is testing whether a new combination of oral drugs works as well as a standard treatment for advanced colorectal cancer that has stopped responding to previous therapies. Researchers will compare two different drug pairs in 236 patients to see which helps control cance…

This study compares two different radiation treatments for adults with lung cancer that has spread to many areas of the brain. One treatment combines a targeted radiation with a drug (bevacizumab) to shrink tumors. The other uses a special whole-brain radiation that tries to spar…

This study is testing if a special, low-calorie 'fasting-mimicking' diet can make standard chemotherapy and immunotherapy work better for people with a hard-to-treat type of breast cancer. It will involve about 80 women with early or locally advanced triple-negative breast cancer…

This study aims to find out if radiation therapy after surgery helps prevent a rare and aggressive adrenal gland cancer from coming back. It will enroll 58 patients who have had surgery and are at high risk of recurrence. Participants will be randomly assigned to either receive r…

This early-phase study is testing a new type of cell therapy called TCR-T for people with advanced solid tumors that have specific KRAS gene mutations. It aims to see if it is safe and if it can help control the cancer. The treatment involves collecting a patient's own immune cel…

This study is testing a combination of three drugs (chidamide, toripalimab, and anlotinib) for people with advanced nasopharyngeal cancer that has come back or spread after at least one prior treatment. The main goals are to find the safest dose of chidamide in this combo and to …

This study is testing whether adding the drug nintedanib to standard hormone therapy can help women with adenomyosis have a successful pregnancy. It will involve 328 women with infertility and adenomyosis who have frozen embryos ready for transfer. Participants will take either t…

This study is testing a new combination of three drugs (QL1706, lenvatinib, and nab-paclitaxel) for men with advanced penile cancer that has come back or stopped responding to other treatments. The main goals are to see if this combination can shrink tumors or delay cancer growth…

This study is testing whether a new combination of two immunotherapy drugs, scipibaimab and tislelizumab, can help control advanced nasopharyngeal cancer that has come back or spread after standard first-line treatments have stopped working. It will involve about 37 adults whose …

This study is testing a new drug called becotatug vedotin for people with advanced nasopharyngeal cancer (a type of throat cancer) whose cancer doesn't shrink enough after initial chemo-immunotherapy. The goal is to see if adding this drug during radiation and follow-up treatment…

This study is testing a three-part treatment for advanced bile duct cancer that cannot be removed by surgery. It combines targeted chemotherapy delivered directly to the liver with two drugs taken by mouth and through an IV. The goal is to see if this combination can shrink tumor…

This study is testing a new treatment approach for people with a specific type of locally advanced rectal cancer that doesn't typically respond well to immunotherapy alone. About 66 participants will receive a short course of radiation, followed by a combination of a new immunoth…

This study tests a chemotherapy-free combination treatment given before surgery for certain types of operable lung cancer. It aims to shrink tumors using targeted radiation, immunotherapy, and a drug that blocks tumor blood vessels, hoping to improve surgical outcomes and reduce …

This study is testing whether a combination of two newer drugs can help control advanced non-small cell lung cancer that has specific genetic features (HER2 abnormalities). It will enroll about 30 adults, including those who have already tried standard treatment and those who hav…

This study aims to find the best timing for chemotherapy in people with high-risk colon cancer. It will compare giving four cycles of chemotherapy before surgery versus having surgery first followed by standard chemotherapy. The main goal is to see if the 'chemo first' approach h…

This study tests different combinations of treatments given before surgery for liver cancer that can be removed. The goal is to see if adding immunotherapy drugs and/or a targeted drug to standard local treatments (like TACE or ablation) can help keep the cancer from returning af…

This study aims to find out if a non-surgical, targeted radiation treatment is as good as or better than surgery for people with a single, small liver tumor. About 312 patients will be randomly assigned to receive either the standard surgery or the radiation treatment. The main g…

This study is testing whether adding an immunotherapy drug (serplulimab) to a strong chemotherapy regimen (FOLFOXIRI) and radiation works better than standard chemotherapy (CAPOX) and radiation for adults with locally advanced low rectal cancer. The goal is to shrink tumors befor…

This large Phase 3 trial is testing if adding an oral chemotherapy drug (capecitabine) to a standard immunotherapy drug (adebrelimab) works better to control cancer after initial treatment. It's for patients with advanced nasopharyngeal cancer who still have signs of the Epstein-…

This study is testing if adding a drug called lubiprostone to standard follow-up care can help prevent cancer from returning in people who had surgery for colorectal cancer that had spread to the abdominal lining. About 124 participants will be randomly assigned to receive either…

This study is testing a combination of three drugs (docetaxel, nimotuzumab, and pucotenlimab) for people with advanced head and neck cancer that has returned or spread after previous treatments failed. The goal is to see if this new combination can shrink tumors and control the d…

This study is testing a new combination treatment for people with high-risk, locally advanced rectal cancer. It aims to see if using a shorter, more intense course of radiation along with chemotherapy and an immunotherapy drug is safe and effective at shrinking or eliminating the…

This study is testing whether adding a new drug called lisatoclax to standard lymphoma treatments is safe and effective for people with untreated diffuse large B-cell lymphoma. Researchers will enroll 122 patients to receive either lisatoclax plus R-CHOP or lisatoclax plus Pola-R…

This study is testing a new combination of drugs (tunlametinib plus others) for people with advanced non-small cell lung cancer that has a specific genetic change called a KRAS mutation and has stopped responding to standard treatments. It aims to see if this combination can shri…

This study is testing whether adding a new drug called fruquintinib to standard chemotherapy works better than chemotherapy alone for advanced endometrial cancer that has not spread to other organs. It will involve 128 women with this specific type of cancer who have not had prio…

This study is testing whether a combination of two drugs, Lucanisatuzumab and Tagolisumab, can help control advanced breast cancer that has grown despite standard hormone-blocking therapy. It will enroll about 35 patients whose cancer tests positive for a specific marker (PD-L1).…

This study is testing a new flexible tube (sheath) used during a minimally invasive heart valve replacement procedure called TAVR. The goal is to see if this bendable tube makes it easier and safer for doctors to guide the new valve into the correct position. The research will in…

This study is testing a new drug combination for adults whose T-cell or NK-cell lymphoma has returned or hasn't responded to standard treatments. The main goals are to find a safe and effective dose and to see if the treatment can shrink or eliminate the cancer. It will involve a…

This study is testing whether a drug called Ivonescimab can help control stage III non-small cell lung cancer after patients complete standard chemo-radiation treatment. The trial will enroll 63 patients who have not gotten worse after their initial therapy. Participants will rec…

This study is testing whether a drug called trilaciclib can protect a patient's bone marrow and blood cells during chemotherapy for advanced triple-negative breast cancer. The goal is to reduce severe side effects like infections and fatigue, which often force doctors to delay or…

This study is for people with advanced digestive cancers who have a painful buildup of fluid in the abdomen (malignant ascites) that hasn't responded to standard treatments. It tests a combination of three things: a low dose of radiation, a drug injected directly into the abdomen…

This study is testing whether adding a special low-dose radiation to a standard chemotherapy and immunotherapy combination can better control advanced nasopharyngeal cancer that has returned or spread. It will involve about 55 adults with this specific type of head and neck cance…

This study aims to develop and test an artificial intelligence (AI) model that can predict how well a patient's NK/T-cell lymphoma will respond to their first treatment. The AI will analyze a patient's medical scans and tissue images to try to forecast the outcome before treatmen…

This study compares two methods for guiding the placement of long-term IV lines (PICC lines) in cancer patients. Researchers will test a newer magnetic tracking system against the traditional ECG-guided method to see which is more accurate and leads to fewer complications. The go…

This study is testing a 4-week online program designed to help parents better support healthy habits in their preschool children (ages 3-6). Researchers will enroll 80 parents and compare those who take the program immediately to those on a waitlist. The goal is to see if the pro…

This study is testing a new 'Flipped Discharge' support program for colorectal cancer patients who have a new stoma after surgery. The program shifts key care and education from the hospital to the home, providing a nurse visit or intensive video follow-up a few days after patien…

This study is testing whether a virtual AI chat companion can help teenagers cope with recent stressful life events. About 50 teens aged 14-25 will chat with the virtual agent for 4 weeks to get support with emotions and coping strategies. Researchers want to see if it's a helpfu…

This study is testing if adding a small dose of morphine injected into the spine, along with a standard abdominal nerve block, improves recovery after minimally invasive gynecologic surgery. Researchers will compare pain levels, opioid use, and overall recovery quality in 252 pat…

This study is testing different blood test methods to detect tiny amounts of leftover cancer cells in people who have had surgery for stage III colorectal cancer. Researchers will collect blood samples from 229 patients and analyze them to see which test method best predicts if c…

This study aims to develop a better way to measure and understand a specific eye condition called central serous chorioretinopathy (CSC), which can cause vision loss. Researchers will use a special, detailed eye scan on 120 people, including patients and healthy volunteers, to cr…