St. Jude Children's Research Hospital

This study aims to cure children with acute lymphoblastic leukemia and lymphoma by personalizing their treatment. Doctors use genetic tests on each child's cancer to choose targeted drugs or advanced immunotherapies. The goal is to improve survival rates and quality of life by ma…

This study is testing a new experimental vaccine given as nose drops to try to prevent croup, a common respiratory illness in young children caused by a virus. The vaccine uses a harmless virus similar to the one that causes croup. Researchers are checking if the vaccine is safe …

This study tested a new gene therapy method for infants with SCID-X1, a severe genetic immune disorder. Doctors collected the baby's own bone marrow cells, inserted a corrected gene copy in the lab, and then returned the cells to the baby. The goal was to see if this procedure wa…

This study is for children and young adults (up to age 21) with high-risk blood cancers like leukemia and lymphoma. It tests a modified blood cell transplant from a partially matched family donor. The donor cells are processed in a lab to remove certain immune cells that can caus…

This study is testing whether a shorter, 8-week chemotherapy regimen works as well as longer treatments for children with favorable-risk Hodgkin lymphoma. Some patients who still show cancer after chemotherapy also receive targeted, low-dose radiation. The goal is to effectively …

This study is testing whether adding two cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants under 1 year old with acute lymphoblastic leukemia (ALL). Researchers want to see if this combination helps more babies survive longer with…

This study is testing the drug CPX-351 in patients under 22 years old who have developed secondary myeloid neoplasms, which are blood cancers that can occur after previous cancer treatments or due to genetic conditions. Participants receive up to two cycles of CPX-351 to try to a…

This study is testing a more precise form of radiation therapy for children and young adults with bone and soft tissue cancers like sarcoma. The goal is to see if using advanced imaging to guide the radiation can better control the tumor while causing fewer long-term side effects…

This study is testing different combinations of chemotherapy drugs for children and young adults with Hodgkin lymphoma, based on how advanced their cancer is. The goal is to control the disease and prevent it from coming back. Doctors will also closely monitor side effects and th…

This study is testing a personalized cell therapy called SJCAR19 for children and young adults (up to age 21) whose acute lymphoblastic leukemia (ALL) has come back or hasn't responded to standard treatments. Doctors collect a patient's own immune cells, modify them in a lab to b…

This study tested a combination of two drugs, temozolomide and peginterferon, to see how well they work in children with high-risk or advanced melanoma. The goal was to see if the treatment could shrink tumors and prevent the cancer from coming back. Children were placed in diffe…

This study is testing a personalized treatment plan for children and young adults with rhabdomyosarcoma, a rare muscle cancer. Doctors use proton beam radiation, surgery, and chemotherapy tailored to each patient's risk level. The goal is to control the cancer while reducing side…

This study is testing a new combination of drugs for young patients (up to age 25) with high-risk Ewing sarcoma and desmoplastic small round cell tumors. Patients are divided into two groups: those with lower-risk tumors receive standard treatment, while those with higher-risk tu…

This early-stage study is testing the safety of a one-time gene therapy for adults with severe hemophilia B. Researchers are using a modified, harmless virus to deliver a working copy of the Factor IX gene directly to the liver, aiming to help the body produce its own clotting pr…

This study aims to improve care for children and young adults with B-cell lymphoma. It tests a modified version of a successful chemotherapy regimen while also collecting tumor samples from around the world to better understand the biology of these cancers. The research focuses o…

This study is testing a new combination of two drugs, venetoclax and navitoclax, for children and young adults whose acute lymphoblastic leukemia has come back or hasn't responded to previous treatments. The main goals are to see if this combination can effectively clear the canc…

This study is testing a newer, more precise form of radiation called intensity-modulated proton therapy for children and young adults with a rare brain tumor called craniopharyngioma. The main goal is to see if this advanced radiation can effectively control the tumor while causi…

This study is testing whether surgery followed by a carefully planned second course of radiation can help control ependymoma, a type of brain tumor, that has come back after initial treatment. It involves children and young adults (ages 1-21) whose tumor has progressed. The main …

This study is testing a treatment approach for a rare brain tumor called craniopharyngioma in patients up to age 21. It compares two groups: one receives less extensive surgery followed by targeted proton radiation, while the other is observed after complete surgical removal. The…

This study is testing a new combination of treatments for children and teens with high-risk Hodgkin lymphoma. It replaces one standard chemotherapy drug with a newer, targeted drug called brentuximab vedotin, which is designed to attack cancer cells more precisely. The goal is to…

This study tested a new antibody drug (hu14.18K322A) given alongside standard chemotherapy for children with advanced, high-risk neuroblastoma. The goal was to see if adding this antibody, which targets cancer cells, improves treatment response and survival. The trial involved 15…

This study tested a treatment plan for children under 5 with aggressive brain tumors. Doctors used a combination of chemotherapy drugs to try to shrink the tumor and delay radiation, giving the young brain more time to develop. The goal was to control the cancer while aiming to r…

This study is testing a new, personalized approach to treating medulloblastoma, a type of brain cancer in children. Doctors will analyze each child's tumor to determine its genetic type and risk level, then assign a specific combination of surgery, radiation, and chemotherapy. Th…

This study is testing if giving a special 'priming' drug for five days before standard chemotherapy helps children and young adults with acute myeloid leukemia (AML). The goal is to see if this approach is safe and if it makes the chemotherapy more effective at controlling the ca…

This study is testing whether adding a drug called venetoclax to standard chemotherapy is safe and effective for children and young adults with newly diagnosed acute myeloid leukemia (AML). It will involve about 70 participants under 22 years old. The main goals are to see if the…

This study is testing a drug called alisertib for children and young adults with rare, aggressive tumors called AT/RT and MRT. It is for patients whose cancer has come back and for those newly diagnosed. The goal is to see if adding alisertib to standard treatments helps control …

This study is testing two different drug combinations to see if they can reduce the number of 'aged' cells in the body and improve physical frailty in adults who survived childhood cancer. The trial will involve about 110 participants who are already experiencing frailty. Researc…

This study is testing a new treatment plan for a rare and serious immune system disorder called Hemophagocytic Lymphohistiocytosis (HLH). It combines an existing drug, ruxolitinib, with standard medications, adjusting the treatment based on how well the patient responds. The goal…

This study is testing a new combination of oral drugs (selinexor and venetoclax) with standard chemotherapy for children and young adults whose acute myeloid leukemia (AML) has returned or hasn't responded to previous treatments. The main goal is to find the safest and most effec…

This study is testing a new type of blood test to see if it can predict dangerous bloodstream infections in children and young adults with cancer before they happen. The goal is to help doctors start the right antibiotic treatment earlier, which could prevent severe illness. The …

This study is testing a new type of imaging scan to see if it can better detect and monitor tumors in children and young adults with cancer. The scan uses a radioactive form of a natural protein building block called methionine. Researchers want to see how well this new scan work…

This study compares heart rhythm readings from an Apple Watch to standard clinical ECG tests in adult survivors of childhood cancer. Researchers want to see if the smartwatch readings match the clinical tests and can predict future heart damage risk. The goal is to develop a mode…

This study is testing a new radioactive tracer called 18F-DA for PET scans to see if it can create clearer pictures of neuroblastoma and pheochromocytoma tumors than the current standard. Researchers want to check if it's safe and if it goes to the right places in the body. About…

This study is testing whether a combination of a common diabetes prevention drug (metformin) and a digital lifestyle coaching program can help prevent adult survivors of childhood cancer from developing full diabetes. The main goal is to see if this combined approach is safe and …

This study is testing whether a home-based light therapy device, used alongside computer brain training games, can help improve memory, attention, and thinking skills in adult survivors of childhood leukemia or Hodgkin's lymphoma. Participants use the device at home three times a…

This study aims to update existing exercise videos originally made for older adults so they are more suitable for adult survivors of childhood cancer. Researchers are asking 10 survivors to watch the videos and provide feedback in interviews. The goal is to create a helpful tool …

This study is testing whether a personalized, home-based exercise program delivered via telehealth can help childhood cancer survivors who have difficulty with physical activity. Researchers are comparing a tailored exercise plan to general activity guidelines to see which better…

This pilot study is testing whether adult survivors of childhood cancer will participate in two behavioral interventions at the same time. It combines exercise with either computer-based brain training or mindfulness practice over 12 weeks. The goal is to see if these combined ap…

This study is testing whether a daily mindfulness meditation app is a practical and helpful way for adult survivors of childhood leukemia or lymphoma to manage stress. Fifty participants will use the Headspace app for 30 days, wear a wrist device to measure stress signals, and an…

This study aims to understand how common obstructive sleep apnea is in adult survivors of Hodgkin lymphoma who were treated with chest radiation. Researchers will compare 220 survivors to a group of healthy people matched for age, gender, race, and weight. The study involves slee…

This study aims to understand how cancer treatment affects the social lives, friendships, and sense of connection in adolescents and young adults (ages 15-22). Researchers are surveying and interviewing 121 young people who are either currently receiving treatment or finished tre…

This study aims to understand how cancer treatment affects social and emotional development in young children. Researchers are following children ages 4-6 who have completed cancer treatment, assessing their social skills and behavior at two time points. The goal is to learn how …

This study is testing a 'smart' pill bottle to see if it's a good way to measure how consistently teens with sickle cell disease take their daily medication (hydroxyurea). The bottle tracks when it's opened and sends the data to researchers. The goal is to find a more accurate me…

This study aims to understand the psychological impact of childhood cancer. It compares stress levels and potential for positive personal growth in children with cancer and their parents against families without serious illness. Researchers are following participants over time to…

This study is observing 1,000 children who have already received proton therapy for cancer at St. Jude Children's Research Hospital. The goal is to collect long-term safety data over 10 years to understand the risks of serious side effects from this type of radiation. The childre…

This study aims to understand why many young adults who survived childhood cancer experience early signs of aging and frailty, which can lead to serious health problems later in life. Researchers will follow over 1,500 survivors for five years, measuring their physical fitness an…

This study aims to learn how well COVID-19 vaccines protect children and young adults under 24 who have cancer or have received a transplant or cellular therapy. Researchers will measure the strength and duration of the immune response in these vulnerable patients by taking small…

This study aims to understand how radiation therapy for brain tumors causes inflammation in the brain. Researchers will use special PET scans and optional MRI scans on 22 children with medulloblastoma to measure this inflammation over two years. The goal is to learn how this infl…

This study is testing whether a special heart scan (MRI) can be done safely and successfully in children with cancer who have recently recovered from a severe infection called sepsis. The goal is to see if these scans can find hidden heart problems, like inflammation or weakness,…

This study aims to see if data from smartphones and wearable devices can help predict which adult survivors of childhood cancer might develop future health problems. Over 600 survivors will use their phones and wearables to track symptoms, activity, sleep, and heart rate over two…

This study is collecting imaging data from children receiving proton radiation therapy for cancer. The goal is to understand and reduce errors in patient positioning during treatment. By analyzing these images, researchers hope to make future radiation therapy more accurate and e…

This study aims to create and test a new questionnaire to help adult survivors of childhood cancer report their long-term symptoms and health problems. Researchers are working with over 800 survivors to identify which symptoms matter most and to make sure the questionnaire is acc…