St. Jude Children's Research Hospital

This study is testing whether adding a new immune therapy called CAR-T cells after standard chemotherapy can help prevent cancer from returning in children with high-risk osteosarcoma (bone cancer). Researchers will enroll 41 children who have completed their initial chemotherapy…

This study is testing whether a weekly weight-loss medication (Tirzepatide) combined with a remote, supervised exercise program can help adult survivors of childhood leukemia lose weight and improve their heart and metabolic health. The 28-week program aims to see if participants…

This study is testing whether wearing special light therapy glasses can help reduce depression, fatigue, and sleep problems in children and teenagers who are receiving a stem cell transplant. About 98 participants, aged 8 to 18, will wear the glasses for 30 minutes a day for four…

This pilot study is testing whether a 12-week high-intensity interval training (HIIT) exercise program is practical and safe for young Hodgkin lymphoma survivors who finished treatment within the last two years. Researchers will enroll 20 participants to see if they can complete …

This study aims to better understand the side effects of asparaginase, a drug commonly used to treat childhood leukemia. Researchers will collect data and perform liver scans on 200 children and young adults receiving standard leukemia treatment. The goal is to measure how often …

This study is testing whether adult survivors of childhood cancer will use a remote monitoring program to track their heart and metabolic health. Participants will wear devices, complete surveys, and do lab tests from home over 12 weeks. The goal is to see if this remote approach…

This study aims to learn if a non-invasive light therapy, aimed at the forehead, can improve thinking skills and oxygen use in the brains of children with sickle cell disease. Researchers will enroll 60 children, aged 8-17, who will be randomly assigned to receive either the real…

This study aims to understand if young adults with a genetic condition that increases cancer risk successfully move from pediatric to adult healthcare. Researchers will follow 56 people for 8 years after they leave St. Jude Children's Research Hospital, checking if they find adul…

This study aims to understand the long-term effects of gene therapy on the liver in adults with hemophilia. Researchers will analyze small liver tissue samples from up to 8 people who received gene therapy at least 6 months ago. The goal is to see how the liver cells have respond…