Can a light cap boost brain power in kids with sickle cell?
NCT ID NCT06797583
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether shining a special light on the head (transcranial photobiomodulation) can improve oxygen use and thinking skills in children with sickle cell disease. The brain needs steady oxygen, but sickle cell can reduce blood flow. Researchers will randomly assign 60 children (ages 8-17) to receive either active light therapy or a sham (placebo) treatment. The main goal is to see if the therapy is feasible and acceptable, and to check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Transcranial photobiomodulation (light therapy using a CytonBrite 1064nm LED device)
- What this could lead to
- If it works, this could point toward a new way to improve brain function and oxygen use in children with sickle cell disease.
- What could go wrong
- This is a very early feasibility study with only 60 participants. It is designed mainly to see if the approach is acceptable and safe, not to prove it works. The light therapy may not improve thinking or oxygen levels.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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