St. Jude Children's Research Hospital

This study tested personalized treatment plans for children with retinoblastoma, a rare cancer of the eye. Researchers aimed to see if new combinations of chemotherapy drugs could effectively control the cancer while preserving the child's vision and eye. The trial also tracked h…

This early-stage study tested a new two-step stem cell transplant method for children and young adults whose cancers had returned or didn't respond to standard treatments. The goal was to see if this approach, which uses specially processed cells from a partially matched family d…

This study tested whether a drug called avelumab could help control a rare and aggressive bone cancer called osteosarcoma when it comes back after standard treatment. It involved 19 patients aged 12 to 50 whose cancer had returned or worsened. The main goals were to see if the dr…

This study tested whether keeping blood pressure in a tighter, lower range could prevent severe bone damage (osteonecrosis) in children and young adults being treated for a type of blood cancer (acute lymphoblastic leukemia/lymphoma). It compared a more intensive blood pressure c…

This study tested an online program to help adult survivors of childhood cancer who struggle with insomnia and thinking problems. Over 1,500 participants were randomly assigned to either a 9-week internet-based sleep therapy program or basic sleep education. Researchers measured …

This study tested a new way to help young survivors of childhood bone cancer manage their chronic pain. Researchers first worked with Black and Hispanic survivors to adapt a mobile therapy app to be more culturally sensitive. They then tested if using this app, along with a mild,…

This study aimed to learn about the community of microbes (like bacteria, fungi, and viruses) living in the mouths and noses of children with cancer. Researchers collected samples from 62 children with leukemia or those receiving a bone marrow transplant at three different times …

This study aimed to test and improve surveys that ask childhood cancer survivors about their health and quality of life. Researchers followed about 300 survivors and their parents for three years, comparing survey answers with results from medical check-ups. The goal was to make …

This study aimed to understand how young adults with sickle cell disease move from pediatric to adult healthcare. Researchers followed 94 patients aged 16-21 to track their hospital visits, medication use, and quality of life during this critical transition period. The goal was t…

This study tested whether a special type of MRI scan, which uses no radiation, could work as well as standard scans that do use radiation for children with bone and soft tissue cancers (sarcomas). Researchers wanted to see if this safer method could correctly identify where the c…

This study aimed to understand how surviving a childhood brain tumor affects a child's ability to make friends and interact socially. Researchers observed 80 children, aged 8 to 12, who were at least two years past their cancer treatment. They tracked the children's daily social …

This study surveyed 150 hemophilia B patients, their caregivers, and healthcare workers worldwide to understand what they know and think about gene therapy. Researchers conducted interviews to learn about people's attitudes, concerns, and how they prefer to receive information ab…

This study explored how parents experienced hope while their child was receiving hospice care. Researchers asked 20 bereaved parents to select personal photos that represented hope to them during that difficult time. Through one-on-one interviews about these photos, the study aim…

This study tested if a commercially available wrist-worn fitness monitor (WHOOP®) could reliably measure heart rate and heart rate variability from home for survivors of Hodgkin lymphoma who had chest radiation. The goal was to see if the home monitor's readings matched those fro…