Precision proton beams and chemo aim to beat childhood muscle cancer

NCT ID NCT01871766

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a personalized treatment plan for children with a rare muscle cancer called rhabdomyosarcoma. Depending on their risk level, patients receive standard or stronger chemotherapy, plus focused proton beam radiation and/or surgery to remove the tumor. The goal is to improve survival while limiting damage to healthy tissue.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vincristine, dactinomycin, cyclophosphamide, and anti-angiogenic maintenance therapy
What this could lead to: If successful, this approach could improve event-free survival for children with intermediate- and high-risk rhabdomyosarcoma while reducing side effects from radiation.
What could go wrong: This is a Phase 2 trial with a relatively small number of participants (115). The results may not generalize to all patients, and intensified chemotherapy carries risks of serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHABDOMYOSARCOMA

Contacts and locations

Locations

Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Nemours Children's Clinic

Jacksonville, Florida, 32207, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
University of Florida Proton Therapy Institute

Jacksonville, Florida, 32206, United States

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