Precision proton beams and chemo aim to beat childhood muscle cancer
NCT ID NCT01871766
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a personalized treatment plan for children with a rare muscle cancer called rhabdomyosarcoma. Depending on their risk level, patients receive standard or stronger chemotherapy, plus focused proton beam radiation and/or surgery to remove the tumor. The goal is to improve survival while limiting damage to healthy tissue.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vincristine, dactinomycin, cyclophosphamide, and anti-angiogenic maintenance therapy
What this could lead to
If successful, this approach could improve event-free survival for children with intermediate- and high-risk rhabdomyosarcoma while reducing side effects from radiation.
What could go wrong
This is a Phase 2 trial with a relatively small number of participants (115). The results may not generalize to all patients, and intensified chemotherapy carries risks of serious side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Nemours Children's Clinic
Jacksonville, Florida, 32207, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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University of Florida Proton Therapy Institute
Jacksonville, Florida, 32206, United States