Hope for kids with leukemia: new drug combo aims to boost remission

NCT ID NCT05955261

Terminated Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether adding the targeted drug venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The study aims to see if this combination can reduce the amount of cancer left after the first round of treatment. About 70 participants will receive different numbers of treatment cycles based on their risk level.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Venetoclax (a targeted drug) combined with standard chemotherapy drugs (azacitidine, cytarabine, gemtuzumab ozogamicin)
What this could lead to: If successful, this could lead to a more effective treatment for pediatric AML, helping more children achieve remission with fewer remaining cancer cells.
What could go wrong: This is an early-phase trial with only 70 participants, so results may not apply to all patients. Adding venetoclax to chemotherapy may increase side effects, and the study is currently suspended, which may indicate safety or recruitment issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE MYELOID LEUKEMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome myelodysplastic syndrome with excess blasts-2 myeloid sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital

Chicago, Illinois, 60611, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20020, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States
Rady Children's Hospital-San Diego

San Diego, California, 92123, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Valley Children's Hospital

Madera, California, 93636, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.