Hope for kids with leukemia: new drug combo aims to boost remission
NCT ID NCT05955261
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding the targeted drug venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The study aims to see if this combination can reduce the amount of cancer left after the first round of treatment. About 70 participants will receive different numbers of treatment cycles based on their risk level.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Venetoclax (a targeted drug) combined with standard chemotherapy drugs (azacitidine, cytarabine, gemtuzumab ozogamicin)
What this could lead to
If successful, this could lead to a more effective treatment for pediatric AML, helping more children achieve remission with fewer remaining cancer cells.
What could go wrong
This is an early-phase trial with only 70 participants, so results may not apply to all patients. Adding venetoclax to chemotherapy may increase side effects, and the study is currently suspended, which may indicate safety or recruitment issues.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ann & Robert H. Lurie Children's Hospital
Chicago, Illinois, 60611, United States
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20020, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204, United States
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Rady Children's Hospital-San Diego
San Diego, California, 92123, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Valley Children's Hospital
Madera, California, 93636, United States