Promising new combo aims to shrink tumors faster in kids with tough hodgkin lymphoma

NCT ID NCT01920932

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether replacing a standard chemo drug with Adcetris (brentuximab vedotin) can improve early tumor shrinkage in children with high-risk Hodgkin lymphoma. About 77 participants will receive two cycles of the new combo, followed by more chemo and possibly radiation. The goal is to see if more kids achieve a complete response early, potentially reducing the need for radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brentuximab vedotin (Adcetris) plus chemotherapy (etoposide, prednisone, doxorubicin, cyclophosphamide, dacarbazine) and radiation therapy
What this could lead to: If successful, this approach could improve early cancer clearance and reduce the need for radiation in children with high-risk Hodgkin lymphoma.
What could go wrong: This is a small, early-phase trial (77 participants) with no control group. Results may not generalize, and side effects from the drug combination could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAGE II CHILDHOOD HODGKIN LYMPHOMA STAGE III CHILDHOOD HODGKIN LYMPHOMA STAGE IV CHILDHOOD HODGKIN LYMPHOMA

Contacts and locations

Locations

Dana-Farber Harvard Cancer Center

Boston, Massachusetts, 02115, United States
Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States
Maine Children's Cancer Program (MCCP)

Scarborough, Maine, 04704, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
St. Jude Midwest Affiliate

Peoria, Illinois, 61637, United States

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