New combo therapy shows promise for kids with advanced melanoma
NCT ID NCT00539591
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase II study tested a combination of two drugs—peginterferon alfa-2b and temozolomide—in 29 children with high-risk melanoma that had spread or come back. The main goal was to see how well the tumors shrank and to check for side effects. The study also looked at how long children stayed cancer-free after treatment with peginterferon alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Peginterferon alfa-2b and temozolomide
- What this could lead to
- If successful, this combination could offer a new treatment option for children with advanced melanoma that cannot be removed by surgery.
- What could go wrong
- This is a small, early-phase study (Phase II) with only 29 participants, so results may not apply to all children. The drugs can cause serious side effects like severe mood changes and organ toxicity.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rady Children's Hospital
San Diego, California, 92123, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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The Children's Cancer Hospital at UT M.D. Anderson Cancer Center
Houston, Texas, 77030, United States
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