Centre Hospitalier Universitaire De Saint Etienne

This study looks at whether giving the 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever is as effective and safe as waiting until they are well. About 1052 adults with certain health risks (like heart or lung disease) will take part. The goal is to see if…

This study tests whether hydroxychloroquine, a drug already used for lupus, can slow kidney damage in people with IgA nephropathy (Berger's disease). About 334 adults in France will receive either the drug or a placebo for several months. The goal is to see if it helps preserve k…

This study looks for the best way to treat people who have a blood clot (like in the leg or lung) and also take daily aspirin or similar drugs for heart disease. Both conditions need blood thinners, but taking them together raises the risk of dangerous bleeding. The trial will co…

This study tests whether a program of adapted physical activity combined with extra nutrition can help women with constitutional thinness gain lean body mass (muscle). Constitutional thinness is a condition where people are naturally very thin and find it hard to gain weight, eve…

This study tests a program that helps prostate cancer patients become more physically active. It combines a personalized exercise plan, coaching from a fellow patient who is already active, and support from a doctor. The goal is to see if this approach helps men stay active long-…

This study tests whether a purine-rich diet can help people with AICA-ribosiduria, a rare genetic condition that causes severe developmental delays, seizures, and growth problems. Researchers will give the diet to 10 participants and measure changes in disease markers in the urin…

This study tests whether a customized rehabilitation program, guided by monthly check-ups from a physiotherapist, can lower the chance of re-injuring the same or opposite knee after ACL reconstruction. About 432 athletes who want to return to competitive sports will take part. Th…

This study tests if rituximab, a drug used for certain blood cancers, can help people with a rare nerve disease called Anti-MAG neuropathy. The disease causes progressive weakness and numbness. About 90 adults with early-stage disease will receive rituximab or a placebo. The main…

This study tests a personalized approach to slowly reduce the dose of the biologic drug adalimumab in people with rheumatoid arthritis who are in remission. The goal is to find the best blood level of the drug before each dose reduction to lower the risk of disease flares. 180 ad…

This study tests a non-invasive brain stimulation technique called tDCS to see if it can reduce cannabis use in people with schizophrenia. Researchers will give 110 participants 10 sessions targeting brain areas linked to control and reward. The goal is to lower cannabis consumpt…

This study looks at people with Crohn's disease whose current medicine (adalimumab) is no longer controlling their symptoms. It compares two options: increasing the dose of adalimumab or switching to a different drug called vedolizumab. The goal is to see which approach leads to …

This study tests whether closely monitoring the amount of sedation and pain medication given during surgery can prevent serious complications like kidney injury, heart problems, and death. It involves 1,132 high-risk patients over 75 or with conditions like heart disease. The goa…

This study aims to create a short, simple questionnaire that doctors can use during routine check-ups to quickly screen childhood cancer survivors for anxiety and depression. About 545 participants aged 6 to 25 who have finished intensive cancer treatment and are in remission wil…

This study aims to find specific protein patterns in the blood that can help doctors diagnose chronic thromboembolic pulmonary hypertension (CTEPH), a rare but serious lung condition that can follow a blood clot in the lungs. Researchers will analyze blood samples from 120 people…

This study is testing whether a simple urine sample can work as well as the standard cervical swab for detecting HPV, the virus that causes almost all cervical cancers. The goal is to make screening easier and more comfortable, especially for women who avoid the current test. Abo…

This study is testing a new, non-invasive urine test to detect clear cell renal cell carcinoma, a common type of kidney cancer. Currently, diagnosis often requires expensive imaging or a painful biopsy. Researchers are looking for tiny particles called exosomes in urine that are …

This study tests whether caregivers playing familiar, ritualized music after meals can help Alzheimer's patients fall asleep faster, sleep longer, and have fewer agitated behaviors during the day. About 120 people living in special care units will wear a bracelet to track their s…

This study tests three non-drug programs to fight fatigue in Sjögren's syndrome: exercise alone, exercise plus acupuncture, or exercise plus a gentle nerve-stimulating device. 174 adults with Sjögren's will try one of these for 12 weeks, and researchers will check their fatigue l…

This study looks at whether adding a foam pad to a standard lumbar belt makes it more comfortable. Researchers will test the belt on 15 healthy adults and people with low back pain. The goal is to see if the pad improves comfort and how it affects the body.

This study tests whether physical activity in green outdoor spaces reduces negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. 45 adults aged 18-55 with persistent negative symptoms will participate. Researchers…

This study compares a new surgical technique called vNOTES (scarless vaginal surgery using a tiny camera) to standard laparoscopic hysterectomy in 200 women with large uteri (over 280 grams). The goal is to see if vNOTES reduces complications like infections, bleeding, or organ i…

This study is for people with long-lasting nerve pain that hasn't gotten better with standard medicines. Researchers are testing whether combining a non-invasive brain stimulation technique (rTMS) with virtual reality mirror therapy can reduce pain more than either treatment alon…

This study tests a personalized 6-month program for older adults being treated for bladder or kidney cancer. The program includes exercise sessions, educational workshops, and support before and after surgery. The goal is to see if it can reduce frailty and improve recovery. Abou…

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study tests whether adding gentle vibrations to the foot muscles of stroke patients can improve walking speed more than standard rehab alone. About 70 people who had a stroke within the past 3 months will take part. Half will get real vibrations, half will get a sham treatme…

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can reduce chronic nerve pain caused by cancer or its treatment. Sixty adults with moderate to severe pain will receive both real and placebo stimulation in a random order, with an 8-week break in…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study looks at how genes relate to different forms of Fuchs' corneal dystrophy, a disease that affects the clear front part of the eye. Researchers will analyze DNA from 500 people who need cornea surgery to find genetic patterns. The goal is to better understand the disease…

This study looks at how people make and respond to nonverbal sounds such as screams, laughter, and grunts. Researchers will record these sounds and measure things like heart rate and skin temperature in up to 2,000 volunteers. The goal is to better understand why we make these so…

This study is testing a new way to measure fatigue in people with spinal muscular atrophy (SMA), a condition that causes muscle weakness. The test is designed to be easy enough for patients with different levels of ability. Researchers want to see if the test is safe, doable, and…

This study looks at whether polishing the inner layer of the cornea before injecting new cells helps remove tiny bumps called guttae in people with Fuchs endothelial corneal dystrophy. Twenty adults scheduled for corneal transplant will have half their cornea polished and the oth…

This study tests a program called PRESTO that helps people with first-episode psychosis get specialized care faster. The program educates the public and trains frontline workers like doctors and teachers to spot early signs. Researchers will measure how long people go without tre…

This study looks at how exercising in the morning versus late afternoon affects sleep quality and body temperature. Researchers will compare endurance athletes with inactive people to see who is more sensitive to exercise timing. The goal is to understand how to best schedule exe…

This study looks at how stroke patients with weakness on one side use visual and touch feedback when imagining movements. Researchers will record brain activity with EEG while patients perform mental tasks. The goal is to understand how different parts of the brain handle these s…

This study is looking for a better way to track disease activity in people with primary Sjögren's syndrome, a chronic autoimmune disease that causes dryness and can affect organs. Researchers will test a new blood marker called anti-Ro/SSA IgE in 185 participants to see if it is …

This study looks at how hearing sounds like screams, laughter, or crying affects people's thoughts and physical reactions. Researchers will play these sounds to 2000 healthy adults and measure things like heart rate, skin temperature, and how fast they respond. The goal is to bet…

This study looks at whether longer or shorter training sessions help healthy adults better resist fatigue during prolonged exercise. Researchers will measure changes in cycling power and heart rate after a 4-hour ride. The goal is to understand how training duration affects physi…

This study looks at whether brain imaging can help predict which people having a first psychotic episode will not get better after 3 months of standard treatment. Researchers will follow 80 people aged 18-35 with a first episode of schizophrenia or related disorders who have neve…

This study is testing a new device called ADHELASKIN to see if it can measure skin stiffness more accurately than the current method (feeling the skin by hand) in people with systemic sclerosis (scleroderma). The study will compare 100 participants: those with scleroderma and hea…

This study looks at how type 1 diabetes affects the nerves that control heart rate and breathing in children. Researchers will measure heart rate variability in 100 children (50 with diabetes and 50 healthy) to detect early signs of nerve damage. The goal is to better understand …

This study tests a new way to manage the hundreds of daily alarms in intensive care units. Many alarms are false or not important, which can stress patients and staff. Researchers will see if a stricter alarm protocol lowers noise and keeps patients safe. About 514 adults in one …

This study looks at whether a short, intense vibration program (5 days) can improve leg muscle strength as much as a longer program (4 weeks) in healthy adults aged 18-45. Participants will receive daily vibration sessions of either 30 or 60 minutes. The goal is to find the most …

This study tests three ways of combining mental practice of movement with tendon vibration in 33 healthy adults aged 18-50. The goal is to see which method best activates brain areas involved in movement. Results will help design better rehabilitation for people who cannot move n…

This study aims to create better custom insoles for people with rheumatoid arthritis who have foot pain. Researchers will use CT scans and motion analysis to build a digital model of how feet move and apply pressure. The goal is to design insoles that reduce pain and improve comf…

This study looks at how a common Wilson's disease medication, D-Penicillamine, affects the skin. Researchers will measure skin elasticity in 120 people—some with Wilson's disease taking the drug and some healthy volunteers. The goal is to better understand the skin damage caused …

This study is for cancer patients who have a blood clot and are taking blood thinners. These drugs can cause serious bleeding in 10-15% of patients. Researchers want to see if a special blood test (thrombin generation assay) can predict who is at higher risk of bleeding during th…

This study looks at whether a simple, non-invasive vibration treatment can prevent muscle weakening when a leg is immobilized. 42 healthy adults aged 18-45 will have one leg in a cast for 3 days. Some will receive daily vibration therapy to see if it helps maintain muscle strengt…

This study looks at how the blood thinner apixaban affects blood clotting in two groups: people newly diagnosed with multiple myeloma and people recovering from total knee replacement. Both groups are at high risk for dangerous blood clots. Researchers want to see if the drug wor…

This study tests a special way for nurses to work with people who have long-term health conditions like diabetes or heart disease. The goal is to help patients become more involved in their own care and make daily decisions about their health. About 420 adults will take part, and…

This study aims to see if completely inactive people can train for 18 months to complete a 100 km mountain ultra-marathon. Researchers will track how many participants stick with the program and finish the race, as well as monitor injuries and overall health. The goal is to under…