ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Clinical trials for ESOPHAGEAL SQUAMOUS CELL CARCINOMA explained in plain language.
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New hope drug enters human testing for Tough-to-Treat cancers
Disease control Recruiting nowThis is the first study in people testing a new drug called EVOLVE104. It aims to find a safe dose and see if it can help control advanced bladder and several types of squamous cell cancers. The study is for patients whose cancer has continued to grow despite standard treatments.
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: EvolveImmune United, Inc • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New drug cocktail aims to shrink tumors before esophageal cancer surgery
Disease control Recruiting nowThis study is testing a combination of three drugs given before surgery for esophageal cancer. The goal is to see if this pre-surgery treatment can shrink tumors more effectively, making surgery more successful and reducing the chance of the cancer coming back. Researchers will e…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Pfizer tests new 'Smart Bomb' cancer drug in advanced disease patients
Disease control Recruiting nowThis early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: Pfizer • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New hope for Tough-to-Treat esophageal cancer in Final-Stage trial
Disease control Recruiting nowThis study is testing an experimental drug called ifinatamab deruxtecan (I-DXd) for people with advanced esophageal cancer that has continued to grow despite receiving standard chemotherapy and immunotherapy. The main goal is to see if I-DXd helps patients live longer compared to…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE3 • Sponsor: Daiichi Sankyo • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Targeted missile drug aims to extend life for tough esophageal cancers
Disease control Recruiting nowThis study is testing a new, targeted drug for people with advanced esophageal cancer whose first treatment has stopped working. The drug is designed to deliver a powerful cancer-killing agent directly to tumor cells, aiming to slow or stop cancer growth. Researchers want to see …
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Fudan University • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New hope for inoperable esophageal cancer patients in trial
Disease control Recruiting nowThis study is testing a new combination of drugs and radiation to control advanced esophageal cancer that cannot be removed by surgery. It will involve 69 adults who have not had prior cancer treatment. The goal is to see if adding a drug called surufatinib to standard chemo-immu…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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New hope for esophageal cancer patients who stopped responding to standard treatment
Disease control Recruiting nowThis study is testing several new drug combinations for people with advanced esophageal cancer that has continued to grow despite previous standard treatment, including immunotherapy. The trial aims to find out if these new combinations are safe and can help control the cancer. I…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Targeted radiation blast tested to keep aggressive esophageal cancer at bay
Disease control Recruiting nowThis study is testing if adding a precise, high-dose internal radiation treatment can help control cancer better for people with a specific type of advanced esophageal cancer. Participants have already received standard chemotherapy, external radiation, and an immunotherapy drug.…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: National Taiwan University Hospital • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New weapon against tough esophageal cancer enters human testing
Disease control Recruiting nowThis study is testing new drug combinations for people with advanced esophageal cancer that cannot be removed by surgery or has spread. Researchers are combining an existing immunotherapy drug (pembrolizumab) with a new targeted drug (I-DXd), with or without standard chemotherapy…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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New pill tested to fight aggressive brain cancers
Disease control Recruiting nowThis study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Neonc Technologies, Inc. • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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First patients receive experimental pill targeting Hard-to-Treat cancers
Disease control Recruiting nowThis is the first-ever human study of an experimental pill called PLX-61639. It is being tested in adults with advanced cancers that have a specific genetic flaw (SMARCA4 mutation) and have stopped responding to standard treatments. The main goals are to find a safe dose and see …
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: Plexium, Inc. • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New Two-Pronged cancer drug enters human trials
Disease control Recruiting nowThis study is testing a new, experimental drug called GI-101 in people with advanced cancers that have spread. The main goals are to find a safe dose and see if the drug, given alone or with other approved cancer medicines, can help shrink tumors. The trial will enroll about 317 …
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: GI Innovation, Inc. • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New Pre-Surgery combo tested for tough esophageal cancer
Disease control Recruiting nowThis study is testing whether giving a combination of an immunotherapy drug (adebrelimab) and chemotherapy before surgery can help people with a specific type of locally advanced esophageal cancer. The goal is to see if this approach shrinks the tumor effectively and makes surger…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: The Affiliated Hospital of Putian University • Aim: Disease control
Last updated Mar 27, 2026 12:37 UTC
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Radiation boost tested to fight spreading esophageal cancer
Disease control Recruiting nowThis study is testing if adding two types of radiation therapy to standard first-line treatment helps people with advanced esophageal cancer that has spread. About 100 adults who haven't had prior cancer treatment will be randomly assigned to receive either the standard immunothe…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Shanghai Chest Hospital • Aim: Disease control
Last updated Mar 25, 2026 14:09 UTC
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New hope for Tough-to-Treat esophageal cancer
Disease control Recruiting nowThis study is testing a new combination treatment for people with advanced esophageal cancer that has worsened after their first treatment. It combines an immunotherapy drug called Ivonescimab with a short, intense course of radiation. The main goals are to see if this approach c…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Anhui Provincial Hospital • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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New cancer drug enters first human trials for multiple advanced cancers
Disease control Recruiting nowThis is a first-in-human study to test the safety and find the right dose of a new drug called PF-08046054/SGN-PDL1V for people with advanced solid tumors. It will be tested alone and in combination with another cancer drug, pembrolizumab. The study is recruiting 714 participants…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: Seagen, a wholly owned subsidiary of Pfizer • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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New combo therapy aims to shrink tumors before esophageal cancer surgery
Disease control Recruiting nowThis study is testing a new three-drug combination given before surgery for locally advanced esophageal cancer. The goal is to see if this treatment can shrink or eliminate the tumor to make surgery more successful and reduce the chance of the cancer coming back. It is for adults…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Shanghai Zhongshan Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Doctors test Tumor-Guided Pre-Surgery plan to boost esophageal cancer cure rates
Disease control Recruiting nowThis study is testing a personalized approach to pre-surgery treatment for locally advanced esophageal cancer. It aims to see if choosing a patient's pre-surgery therapy based on a specific tumor biomarker (called CPS score) can help more patients achieve a complete response, whe…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Fujian Medical University Union Hospital • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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New cancer drug trial tests experimental treatment for multiple tumor types
Disease control Recruiting nowThis early-stage trial is testing an experimental drug called sigvotatug vedotin for people with advanced solid tumors that have spread or cannot be removed by surgery. The study will first determine safe doses, then test the drug alone and in combination with other cancer medica…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: Seagen, a wholly owned subsidiary of Pfizer • Aim: Disease control
Last updated Mar 18, 2026 14:40 UTC
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New 'Smart Bomb' drug targets tough cancers in major trial
Disease control Recruiting nowThis study is testing a new experimental drug called ALE.P02 for adults with advanced squamous cell cancers that have spread or can't be removed by surgery. The drug is designed to target cancer cells that have a specific marker called Claudin-1. Researchers will first find the s…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Alentis Therapeutics AG • Aim: Disease control
Last updated Mar 17, 2026 13:09 UTC
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New cancer drug targets common genetic pathway in multiple tumors
Disease control Recruiting nowThis study is testing a new drug called TER-2013 in people with advanced solid tumors that have specific genetic changes. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for patients who have run out of standard treatment options.
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Terremoto Biosciences Inc. • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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Old drug, new target: fungus fighter joins war on deadly esophageal cancer
Disease control Recruiting nowThis study is testing whether adding a common antifungal drug, itraconazole, to standard chemotherapy and radiation can help eliminate more cancer before surgery for esophageal cancer. Researchers believe the drug may block cancer growth pathways and make tumors more sensitive to…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New hope for esophageal cancer patients: trial tests powerful Pre-Surgery combo
Disease control Recruiting nowThis study is testing a new combination of drugs given before surgery for people with a type of esophageal cancer that can be surgically removed but is locally advanced. The goal is to see if adding a newer immunotherapy drug (AK112) to standard chemotherapy drugs helps shrink th…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Tang-Du Hospital • Aim: Disease control
Last updated Mar 13, 2026 15:06 UTC
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Massive cancer registry launches to map treatment paths
Knowledge-focused Recruiting nowThis study is a national registry that aims to collect information on how patients with advanced stomach or esophageal cancer are actually treated in everyday practice in Germany. It will follow about 1,900 patients for up to two years to understand common treatment sequences and…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Sponsor: iOMEDICO AG • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:31 UTC
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First human test of new cancer imaging agent begins
Knowledge-focused Recruiting nowThis early-stage study aims to understand the safety and imaging properties of an experimental radioactive tracer called RAD301. The research involves 9 participants, including both healthy volunteers and people with specific cancers like pancreatic, lung, or ovarian cancer. Part…
Matched conditions: ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: Radiopharm Theranostics, Ltd • Aim: Knowledge-focused
Last updated Mar 12, 2026 13:50 UTC