New hope for tough esophageal cancer: experimental drug takes on chemo in major trial

NCT ID NCT06644781

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This study tests a new drug called ifinatamab deruxtecan (I-DXd) in people with advanced esophageal cancer that has worsened after standard treatments like platinum chemotherapy and immunotherapy. About 510 adults will be randomly assigned to receive either I-DXd or a standard chemotherapy chosen by their doctor. The main goal is to see if I-DXd helps people live longer.

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Conditions

The condition(s) this trial relates to.

esophageal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aarhus University Hospital
RECRUITING

Arhus N, 8200, Denmark
Affiliated Hospital of Jining Medical University
RECRUITING

Jining, 272029, China
Aichi Cancer Center
RECRUITING

Nagoya, 464-8681, Japan
Akershus Universitetssykehus Hf
RECRUITING

Lørenskog, 1478, Norway
Altnagelvin Area Hospital
RECRUITING

Belfast, BT47 1SB, United Kingdom
Amsterdam UMC - location VUmc
RECRUITING

Amsterdam, 1105 AZ, Netherlands
Antwerp University Hospital
RECRUITING

Edegem, 2650, Belgium
Anyang Cancer Hospital
RECRUITING

Anyang, 455000, China
Asan Medical Center
RECRUITING

Seoul, 5505, South Korea
Asklepios Klinik Altona
RECRUITING

Hamburg, 22763, Germany
Azienda Ospedaliera Universitaria Luigi Vanvitelli
RECRUITING

Naples, 80131, Italy
Baptist Cancer Center
RECRUITING

Memphis, Tennessee, 38120, United States
Barts Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
CHU Brest - Hôpital de la Cavale Blanche
RECRUITING

Brest, 29609, France
CHU Poitiers - Hôpital la Milétrie
RECRUITING

Poitiers, 86000, France
CHU Toulouse Rangueil Service dOncologie médicale
RECRUITING

Toulouse, 31059, France
Cancer Institute Hospital of JFCR
RECRUITING

Kōtoku, 135-8550, Japan
Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centrul de Oncologie Sfantul Nectarie Craiova
RECRUITING

Craiova, 200542, Romania
Changzhou Cancer Hospital
RECRUITING

Changzhou, 213001, China
Charing Cross Hospital
RECRUITING

London, W2 1NY, United Kingdom
Charité - Campus Charité Mitte
RECRUITING

Berlin, 10117, Germany
China Medical University Hospital
NOT_YET_RECRUITING

Taichung, 40447, Taiwan
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun-gun, 58128, South Korea
Chu de Liege
RECRUITING

Liège, 4000, Belgium
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Complejo Hospitalario Universitario de Orense
RECRUITING

Ourense, 32005, Spain
Crlcc Eugene Marquis
RECRUITING

Rennes, 35042, France
Derriford Hospital
RECRUITING

Plymouth, PL6 8DH, United Kingdom
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Gemelli
RECRUITING

Rome, 00168, Italy
Fujian Cancer Hospital
RECRUITING

Fuzhou, 350015, China
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Guangxi Medical University Affiliated Tumor Hospital
RECRUITING

Nanning, 530021, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, 150081, China
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hiroshima University Hospital
RECRUITING

Hiroshima, 734-8551, Japan
Hokkaido University Hospital
RECRUITING

Sapporo, 060-8648, Japan
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital General Universitario de Elche
RECRUITING

Elche, 3203, Spain
Hospital Univ Regional de Málaga Hosp Civil
RECRUITING

Málaga, 29010, Spain
Hospital Universitari i Politecnic La Fé
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33013, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, 39012, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario de Burgos
RECRUITING

Burgos, 9006, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, 31008, Spain
Hubei Cancer Hospital
RECRUITING

Wuhan, 430000, China
Hämatologisch Onkologische Praxis Eppendorf HOPE
RECRUITING

Hamburg, 20249, Germany
Hôpital Européen Georges Pompidou
RECRUITING

Paris, 75015, France
IOV - Istituto Oncologico Veneto IRCCS
RECRUITING

Padova, 35128, Italy
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Ico L Hospitalet - Hospital Duran I Reynals
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Institut Jules Bordet
RECRUITING

Brussels, 1070, Belgium
Institut Régional du Cancer de Montpellier
RECRUITING

Montpellier, 34298, France
Institutul Clinic Fundeni
RECRUITING

Bucharest, 22328, Romania
Jilin Cancer Hospital
RECRUITING

Changchun, 130000, China
Jinan Central Hospital
RECRUITING

Jinan, 250013, China
John Peter Smith Hospital
RECRUITING

Fort Worth, Texas, 76104, United States
Kagawa University Hospital
RECRUITING

Kita-gun, 761-0793, Japan
Kanagawa Cancer Center
RECRUITING

Yokohama, 241-8515, Japan
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 833, Taiwan
Karolinska Universitetssjukhuset Solna
RECRUITING

Solna, 17164, Sweden
Keio University Hospital
RECRUITING

Shinjuku-ku, 160-8582, Japan
Kindai University Hospital
RECRUITING

Ōsaka-sayama, 589-8511, Japan
Klinikum Nuernberg Nord
RECRUITING

Nuremberg, 90419, Germany
Kobe City Hospital Organization Kobe City Medical Center General Hospital
RECRUITING

Kobe, 650-0047, Japan
Korea University Guro Hospital
RECRUITING

Seoul, 8308, South Korea
Krankenhaus Nordwest GmbH
RECRUITING

Frankfurt am Main, 60488, Germany
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, 700-721, South Korea
Liaoning Cancer Hospital and Institute
RECRUITING

Shenyang, 110042, China
Maimonides Cancer Center
RECRUITING

Brooklyn, New York, 11220, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mazowiecki Szpital Wojewódzki
RECRUITING

Siedlce, 08-110, Poland
Memorial Healthcare International S R L
RECRUITING

Bucharest, 13823, Romania
MidAmerica Cancer Care - American Oncology Partners
RECRUITING

Kansas City, Missouri, 64132, United States
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100225, Taiwan
Netherlands Cancer Institute
RECRUITING

Amsterdam, 1066CX, Netherlands
Ninewells Hospital
RECRUITING

Dundee, DD1 9SY, United Kingdom
Odense University Hospital. Department of Research, Oncology
RECRUITING

Odense C, 5000, Denmark
Osaka International Cancer Institute
RECRUITING

Osaka, 541-8567, Japan
Penn State University Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
S.C Radiotherapy Center Cluj S.R.L
RECRUITING

Comuna Floresti, 407280, Romania
S.C. Sigmedical Services SRL
RECRUITING

Suceava, 720284, Romania
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
SHOWA Medical University Hospital
RECRUITING

Shinagawa-ku, 142-8666, Japan
Sahlgrenska Sjukhuset
RECRUITING

Gothenburg, 41345, Sweden
Sainte Catherine Institut du cancer Avignon en Provence
RECRUITING

Avignon, 84918, France
Saitama Cancer Center
RECRUITING

Saitama, 362-0806, Japan
Samsung Medical Center
RECRUITING

Seoul, 6351, South Korea
Sarah Cannon Research Institute UK
RECRUITING

London, W1G 6AD, United Kingdom
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 13620, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 3722, South Korea
Shandong Cancer Hospital
RECRUITING

Jinan, 250117, China
Shikoku Cancer Center
RECRUITING

Matsuyama, 791-0280, Japan
Shizuoka Cancer Center
RECRUITING

Sunto-gun, 411-8777, Japan
Sichuan cancer hospital
RECRUITING

Chengdu, 610041, China
Stavanger University Hospital
RECRUITING

Stavanger, 4011, Norway
Subei Peoples Hospital
RECRUITING

Yangzhou, 225001, China
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
The Catholic University of Korea, Seoul St. Marys Hospital
RECRUITING

Seoul, 6591, South Korea
The Christie
RECRUITING

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Fujian Medical University
RECRUITING

Hefei, 230088, China
The First Affiliated Hospital of Xinxiang Medical University
RECRUITING

Weihui, 453100, China
The University of Osaka Hospital
RECRUITING

Suita-shi, 565-0871, Japan
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, 453000, China
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, 430022, China
Unité de recherche clinique ICANS
RECRUITING

Strasbourg, 67033, France
Univ of California Irvine College of Medicine
RECRUITING

Orange, California, 92868, United States
Universitaetsklinikum Bonn Aoer
RECRUITING

Bonn, 53127, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Jena
RECRUITING

Jena, 07743, Germany
Universitaetsklinikum Leipzig AoeR
RECRUITING

Leipzig, 04103, Germany
Universitaetsklinikum Tuebingen
RECRUITING

Tübingen, 72076, Germany
University College London Hospitals
RECRUITING

London, NW1 2BU, United Kingdom
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Vivantes Klinikum Im Friedrichshain
RECRUITING

Berlin, 10249, Germany
West China Hospital Sichuan University
RECRUITING

Chengdu, 610041, China
Wojskowy Instytut Medyczny
RECRUITING

Warsaw, 04-141, Poland
Zanamed Medical Clinic Sp z o o
RECRUITING

Lublin, 20-362, Poland
Zhongshan Hospital Xiamen University
RECRUITING

Xiamen, 361004, China

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