ACUTE MYELOID LEUKEMIA

This early-stage study tested a combination of two drugs, bortezomib and lenalidomide, in 22 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) had returned after a stem cell transplant. The main goal was to find the highest dose of this drug pair that co…

This early study tested whether a drug called atovaquone could be safely given alongside standard chemotherapy to children and young adults newly diagnosed with acute myeloid leukemia (AML). Researchers wanted to see if patients could tolerate the combined treatment and to measur…

This early-stage study tested a combination of two drugs, veliparib and temozolomide, in adults with acute leukemias that had returned or were hard to treat. The main goal was to find the highest dose patients could safely tolerate. Researchers also wanted to see if the drug comb…

This study tested two different chemotherapy combinations to help keep acute myeloid leukemia (AML) from coming back after initial treatment. It involved 735 younger adults (ages 18-60) whose cancer had responded to first-round chemotherapy but who weren't candidates for stem cel…

This study tested whether the drug dasatinib could help control several rare blood disorders including leukemia, myelofibrosis, and mastocytosis. Participants took dasatinib pills daily for as long as it helped control their disease. Researchers monitored blood counts and bone ma…

This study tested a new treatment for children and adults whose acute myeloid leukemia (AML) returned after a stem cell transplant. Researchers combined a standard donor cell infusion with a special type of donor immune cell, called a 'memory-like' natural killer (NK) cell. The g…

This study looked at whether the drug gilteritinib helps keep acute myeloid leukemia (AML) from returning after a stem cell transplant in patients with a specific genetic change (FLT3). Researchers compared two groups: one from previous trials who received gilteritinib after tran…

This study tested the safety and best dose of a drug called enasidenib, given as a maintenance therapy to prevent cancer from returning. It involved 23 adults with specific genetic types of leukemia or related blood cancers who had just received a stem cell transplant. The main g…

This study tested the safety of a new, gentler transplant method for older adults or those who cannot have a standard bone marrow transplant for leukemia or related blood cancers. The approach uses a small, mismatched donor transplant but skips the strong drugs that suppress the …

This study tested if adding a new oral drug called quizartinib to standard chemotherapy works better and is safe for adults newly diagnosed with a specific type of acute myeloid leukemia (AML). Researchers compared the quizartinib combination against standard chemotherapy plus a …

This early-stage study tested whether a weekly pill called ONC-201 could safely help prevent leukemia or MDS from returning after a stem cell transplant. It involved 20 patients who had recently received a transplant and took the pill for up to one year. The main goal was to chec…

This early-stage study tested the safety of adding a common cholesterol-lowering drug (pitavastatin) to a standard leukemia treatment (venetoclax). It involved 6 adults with either chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML). The main goal was to find the s…

This study tested a two-part treatment for people whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a donor stem cell transplant. It combined a drug called guadecitabine, which may slow cancer growth, with infusions of the donor's white blood ce…

This study tested whether adding 'off-the-shelf' natural killer (NK) immune cells from a donor could make stem cell transplants more effective for adults with high-risk forms of leukemia. The goal was to see if this combination was safe and could help prevent the cancer from comi…

This study tested a new, packaged form of two standard chemotherapy drugs (CPX-351) for adults newly diagnosed with a fast-growing blood cancer called AML. The patients were older or had other health problems, putting them at high risk of severe side effects from standard treatme…

This early-stage study tested a combination of a cancer vaccine, chemotherapy, and immunotherapy in 8 patients with certain high-risk blood cancers. The main goal was to check the safety of this four-drug approach and see if it could help the body's immune system better target an…

This study aimed to find the best strategy for finding bone marrow transplant donors for patients with blood cancers and disorders. It compared whether patients should first search for a perfectly matched unrelated donor or go directly to alternative donors like family members or…

This study tested whether adding the drug venetoclax to a specific chemotherapy regimen (CACAG) works better than the standard '3+7' chemotherapy for people newly diagnosed with acute myeloid leukemia (AML). It involved 200 participants aged 14-75 and aimed to see if the new comb…

This study tested a less intense bone marrow transplant procedure for adults with various blood cancers who needed a transplant but did not have a fully matched donor. It used stem cells from a half-matched family member (like a parent, child, or sibling) after a milder pre-trans…

This early-stage study aimed to find the safest and most effective dose of the drug regorafenib for adults with advanced blood cancers that have returned or stopped responding to standard treatments. It involved 16 participants with conditions like acute myeloid leukemia. The mai…

This study observed how well the approved drug Venetoclax worked for adults newly diagnosed with a fast-growing blood cancer (AML) who were too old or frail for strong chemotherapy. About 120 patients in Switzerland and Austria were followed for two years as they took the drug as…

This early-stage study tested the safety and highest tolerable dose of a new oral drug called KPT-9274. It involved 16 adults with acute myeloid leukemia that had returned or stopped responding to previous treatments. The main goal was to see if the drug was safe and to find the …

This early-stage study aimed to find the safest dose of a four-drug combination for adults newly diagnosed with a specific genetic type of acute myeloid leukemia (AML). Researchers tested adding two newer drugs (gemtuzumab ozogamicin and midostaurin) to a standard two-drug chemot…

This early-stage study tested a new cell therapy called WU-NK-101 in patients with acute myeloid leukemia (AML) that had returned or stopped responding to other treatments. The main goals were to find a safe dose and see how well the body tolerates the treatment. Researchers also…

This study tested whether adding a new targeted drug called gilteritinib to standard chemotherapy was safe and effective for people newly diagnosed with acute myeloid leukemia (AML), a fast-growing blood cancer. The first part of the study aimed to find the safest dose. The secon…

This was the first study in people to test the safety of a new oral drug called JNJ-74856665 for advanced blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The main goal was to find the highest dose patients could tolerate without severe side ef…

This study tested whether giving the antibiotic levofloxacin could prevent serious infections in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) who were receiving azacitidine treatment. Researchers compared 60 patients who either received the prevent…

This study tested a communication tool designed to help older patients with acute myeloid leukemia (AML) talk with their doctors and caregivers about their care. The tool helps assess a patient's health, understand their personal values, and explain treatment options. Researchers…

This study tested if paying for blood transfusions would help people with advanced blood cancers choose hospice care earlier. Patients often delay hospice because they need transfusions, which hospice usually doesn't cover. The research provided free transfusions to see if this h…

This study tested whether adding a palliative care team to standard cancer treatment could improve the experience for patients with acute myeloid leukemia (AML). Palliative care specialists focus on managing symptoms and providing emotional support. The trial involved 160 hospita…

This study tested whether listening to self-chosen music for 30 minutes daily could help reduce the severe fatigue experienced by adults with acute myeloid leukemia during their first round of chemotherapy. Over 21 days, researchers compared fatigue levels and certain blood test …

This study aimed to learn about the community of microbes (like bacteria, fungi, and viruses) living in the mouths and noses of children with cancer. Researchers collected samples from 62 children with leukemia or those receiving a bone marrow transplant at three different times …

This small pilot study tested a new communication tool designed to help older adults with acute myeloid leukemia (AML) and their caregivers have better conversations with their cancer doctors. The tool aimed to help patients clarify their treatment preferences and understand thei…

This small study looked at how much of the drug venetoclax stays in patients' blood during treatment for acute myeloid leukemia. Researchers measured drug levels and how it affected cancer cells to understand why treatment works better for some people than others. The goal is to …

This small pilot study tested whether a telehealth program could help older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) plan for their future medical care. Researchers wanted to see if the online program was easy to use and acceptable to patients,…

This small study aimed to see if traces of leukemia could still be found in frozen pieces of ovary taken from young women with acute myeloid leukemia (AML) who were in remission. The goal was to gather information about the safety of this fertility preservation method. Researcher…