New chemo cocktail aims to beat back leukemia relapse

NCT ID NCT00932412

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether a combination of clofarabine and intermediate-dose cytarabine (CLARA) works better than high-dose cytarabine (HDAC) alone as consolidation therapy for younger adults (18-60) with newly diagnosed acute myeloid leukemia (AML). After initial remission, 735 participants were randomized to receive three cycles of either CLARA or HDAC. The main goal is to see which regimen leads to longer disease-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

clofarabine and cytarabine (CLARA) vs high-dose cytarabine (HDAC)

What this could lead to

If CLARA works better, it could offer a more effective consolidation option for younger AML patients, potentially reducing relapse risk.

What could go wrong

This is a phase 2 trial, so results are preliminary. The CLARA combo may not improve outcomes over standard HDAC and could have different side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Show contact details

Locations

CHU - Hôtel Dieu

Nantes, 44093, France
CHU Dupuytren

Limoges, 87042, France
CHU de Brabois

Vandœuvre-lès-Nancy, 54511, France
Centre A. Lacassagne

Nice, 06100, France
Centre Henri Becquerel - CHRU ROUEN

Rouen, 76038, France
Centre Hospitalier Boulogne/Mer

Boulogne-sur-Mer, 62280, France
Centre Hospitalier Dunkerque

Dunkirk, 59395, France
Centre Hospitalier Huguenin

Saint-Cloud, 92210, France
Centre Hospitalier Meaux

Meaux, 77104, France
Centre Hospitalier Regional et Universitaire d'Angers

Angers, 49033, France
Centre Hospitalier René Dubos

Cergy-Pontoise, 95303, France
Centre Hospitalier Schaffner

Lens, 62307, France
Centre Hospitalier Valenciennes

Valenciennes, 59322, France
Centre Hospitalier Versailles

Le Chesnay, 78150, France
HIA Percy

Clamart, 92141, France
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495, France
Hôpital Archet 1

Nice, 06202, France
Hôpital Avicenne - bobigny

Bobigny, 93009, France
Hôpital Clemenceau - chu Caen

Caen, 14033, France
Hôpital Dubocage

Dijon, 21000, France
Hôpital Haut Lévêque

Pessac, 33604, France
Hôpital Huriez

Lille, 59037, France
Hôpital Michallon

Grenoble, 38043, France
Hôpital Mondor

Créteil, 94010, France
Hôpital Purpan

Toulouse, 31059, France
Hôpital St Louis

Paris, 75010, France
Hôpital Sud - CHU Amiens

Amiens, 80054, France
Hôpital V. Provo

Roubaix, 59056, France
Hôpital Victor Dupouy

Argenteuil, 95107, France
Hôpital de Corbeil

Corbeil, 91100, France
Institut Gustave Roussy

Villejuif, 94800, France
Institut Paoli-Calmette

Marseille, 13273, France
Paris Necker

Paris, 75743, France
Pitié-Salpetrière

Paris, 75013, France