Vascular brain injury

This trial investigates whether a robotic system can improve the accuracy of bone realignment and fixation in orthopaedic trauma surgery. Adults with fractures will receive surgery assisted by the R-Universal® robot, which uses 3D navigation to guide precise movements. The goal i…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests whether a home-based computer cognitive training program (RehaCom) can improve attention and memory in adults with acquired brain injury, including stroke. Thirty participants will either receive the home program plus weekly in-person sessions, or standard in-per…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study tests whether giving ozone gas through the rectum can help protect the brain in children who have suffered a brain injury. 120 children aged 1 month to 18 years will either receive up to 80 rectal ozone sessions plus standard rehab, or rehab alone. The main goal is to …

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests a sleep program for people hospitalized after a leg injury that needed surgery. The program includes sleep medicine, melatonin, and sleep tips. Researchers want to see if it helps patients sleep longer and better, and if it reduces the need for strong painkillers…

This study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study looks at whether a common dietary fiber called inulin can improve fatigue and thinking problems in people recovering from brain injuries. Researchers will give inulin to 130 adults in neurorehabilitation and track changes in their gut bacteria and symptoms. The goal is…

This study tests whether adding gentle electrical stimulation to physical therapy can help people who have had a severe stroke and developed muscle weakness in the ICU. About 24 participants will receive either standard therapy or therapy combined with functional electrical stimu…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study looks at 150 people who have had a brain injury from a stroke, bleed, or trauma. Researchers will track their sleep quality and mental health symptoms for up to a year using wrist monitors, brain activity sensors, and questionnaires. The goal is to understand if poor s…

This study monitors brain electrical activity and blood flow in critically ill patients with acute brain injury who are on a breathing machine. Researchers adjust the machine's pressure settings and perform lung reopening maneuvers, then use EEG and ultrasound to see how the brai…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study looks at how adults with acquired brain injury (like from stroke or trauma) learn connections between things without being directly taught. Researchers will test 40 participants using a task that links pill shapes, functions, and names. The goal is to understand how br…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This observational study looks at how acquired brain injury affects speech and breathing in adults with dysarthria. About 100 participants will have their voice recorded and take breathing tests. The goal is to find better ways to identify the severity and type of dysarthria, hel…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study explores whether using both lung and brain ultrasound can help doctors choose the best ventilator pressure for patients with acute respiratory distress syndrome (ARDS) and acute brain injury. About 30 critically ill adults on breathing machines will be enrolled. The go…

This study looks at 406 patients with acute brain injury who need a breathing machine. Doctors often struggle to know when it's safe to remove the tube, and many patients fail. The goal is to find clues that predict successful weaning, so patients can avoid unnecessary procedures…

This study is testing several non-invasive methods—like pupil checks, EEG, and ultrasound—to see if they can detect life-threatening brain swelling earlier than current methods. Researchers will monitor 720 patients with acute brain injuries in the ICU. The goal is to find reliab…

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. …