University Hospital, Strasbourg, France

This early-stage trial tested a combination of two drugs, rapamycin and irinotecan, in 42 children and young adults aged 1 to 21 with solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose and understand side effects. The drugs …

This study tested whether using ideal body weight (instead of total body weight) to calculate heparin doses during heart-lung bypass reduces excessive bleeding in obese patients. Sixty obese adults scheduled for heart surgery were randomly assigned to receive heparin based on eit…

This study tested whether taking L-arginine supplements for six weeks could improve exercise ability and kidney function in 30 stable heart transplant recipients. The goal was to see if this amino acid could help with common post-transplant problems like poor exercise capacity an…

This study tested a freezing technique called cryoablation on 50 adults with desmoid tumors that had grown despite medical treatment. The goal was to stop tumor growth and ease symptoms without surgery. Researchers used MRI to guide the freezing and check results one year later.

This study tested whether tocilizumab, a drug that blocks inflammation, can help people with primary Sjögren's syndrome—an autoimmune disease causing dry eyes, dry mouth, pain, and fatigue. Researchers gave 110 participants either tocilizumab or a placebo to see if it could reduc…

This study tested whether adding vildagliptin (a diabetes pill) to insulin helps control blood sugar in people with type 2 diabetes who are on hemodialysis. 70 patients were randomly assigned to receive either insulin alone or insulin plus vildagliptin for 12 weeks. The goal was …

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The treatment uses a special gel and LED light to kill bacteria in infected gums. Researchers wanted to see if it helps reduce deep gum pockets and inflammation better than st…

This early-phase study tested a special artificial larynx with valves in 10 adults who had severe swallowing troubles, often after throat cancer. The goal was to see if the device could help them swallow safely and possibly allow them to close their tracheotomy tube. The study fo…

This study tested whether acupuncture can help turn a breech baby (feet or bottom first) into the head-down position before birth. 259 pregnant women with a breech baby at 32-34 weeks received either real acupuncture at a specific point or a sham version. The main goal was to see…

This study looked at 130 kidney transplant patients with BK virus in their blood. It compared two approaches: simply lowering their anti-rejection drugs versus lowering them and switching one drug to everolimus. The goal was to see which method cleared the virus better after 6 mo…

This study tested a new way to rebuild the front part of the lower jaw after it is removed during ear, nose, and throat surgery. Instead of using a piece of bone taken from elsewhere in the body, doctors placed a custom porous titanium implant. The goal was to see if this simpler…

This study tested whether a special plasma product (OctaplasLG) could help treat blood clotting problems in people with septic shock. The trial included 60 adults with septic shock and clotting issues. Researchers measured how quickly treatment was given and looked at survival an…

This early-phase study tested a new approach for stage IIIB/C melanoma, a serious skin cancer that has spread to nearby lymph nodes. Nineteen participants received a procedure that freezes the tumor (cryotherapy) combined with injections of two immunotherapy drugs, ipilimumab and…

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves to destroy tumors without surgery. 25 men with low-to-intermediate risk prostate cancer received the treatment. The main goal was to see if no significant cancer remained one year l…

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

This study looked at whether measuring lactate from a finger-prick (capillary blood) can help doctors identify sepsis in patients who are not in the intensive care unit. Sepsis is a life-threatening response to infection, and early detection is key. The researchers enrolled 60 ad…

This study tested a new handheld gamma camera (CarolIReS) in 110 breast cancer patients to see if it could find sentinel lymph nodes that standard methods miss. The camera was used before and during surgery to guide removal and check if any nodes were left behind. The goal was to…

This study tested a method using both a radioactive tracer and a blue dye to locate sentinel lymph nodes in 100 people with infiltrative breast cancer. The goal was to see if using both together works better than either alone. Researchers also looked at the cost of the procedure.

This study compared two groups of women having planned C-sections: one group received steroid injections (betamethasone) before a C-section at 38 weeks, and the other had a C-section at 39 weeks without steroids. The goal was to see if the steroid helped prevent newborn breathing…

This study tested whether giving intravenous immunoglobulins (IVIG) can prevent BK virus infection after a kidney transplant. The virus can damage the new kidney in up to 10% of patients. 359 adults with low protective antibodies against the virus received either IVIG or no extra…

This study tested a connected biofeedback probe called EMY, which women use at home with a mobile app to train their pelvic floor muscles. The goal was to see if it improves quality of life for women with stress urinary incontinence—leaking urine when coughing, sneezing, or exerc…

This study looked at whether laparoscopic promontofixation, a common surgery for pelvic organ prolapse, can be safely performed as an outpatient procedure. Sixty women who needed the surgery were discharged 8 hours after the operation. The main goal was to see how many needed to …

This study tested whether stronger lumbar traction reduces pain better than gentler traction in people with acute sciatica from a herniated disc. Seventeen patients with leg pain lasting less than six weeks received short-term traction sessions. Researchers measured pain levels a…

This study tested four different ways of conditioning the carbon dioxide gas used during laparoscopic (keyhole) womb surgery. The goal was to see if warming, wetting, or adding a numbing medicine to the gas could prevent a drop in body temperature (hypothermia) and reduce pain af…

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can also reduce impulse control disorders like compulsive gambling, shopping, or eating. 117 adults with Parkinson's and moderate-to-severe impulse control problems took the drug or…

This study looked at a different way to manage pain after chest surgery (thoracotomy) for patients who cannot have the standard epidural pain block. The surgeon placed a small tube near the spine to deliver numbing medicine for 48 hours, and all patients also received morphine th…

This study compared a new device called a hysteroscopic morcellator to the standard resectoscope for removing uterine polyps. The morcellator uses suction and mechanical cutting to remove polyps in pieces, while the standard method uses electrical energy. Researchers wanted to se…

This study tested an online cognitive behavioral therapy (CBT) program designed to reduce stress and prevent mental health problems in health workers caring for COVID-19 patients. 156 healthcare workers participated, receiving either the online CBT or a bibliotherapy program. The…

This study looked at whether rinsing out the follicles (follicular flushing) during egg retrieval helps women who produce very few eggs in IVF get more eggs. 257 women with fewer than 5 mature follicles were randomly assigned to standard egg retrieval or retrieval with flushing. …

This study tested a 5-month therapy program called Dialectical Behavior Therapy (DBT) for 92 adults with autism (without intellectual disability) who had recent self-harm or suicidal behaviors. The goal was to see if DBT could help them better manage their emotions and reduce har…

This study looked at a different way to manage pain after chest surgery (thoracotomy) for people who cannot get an epidural. A thin tube placed by the surgeon near the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All participants al…

This study tested whether a special germ-trapping dressing (Sorbact) helps wounds heal faster after surgery for pilonidal sinus, a painful condition near the tailbone. About 250 adults took part, and researchers compared Sorbact to a standard dressing over 75 days. The goal was t…

This study looked at whether adding a mindfulness-based stress reduction program to an 8-week exercise plan could improve fitness and quality of life in women with breast cancer. 100 women who had finished chemotherapy and were undergoing radiotherapy or hormone therapy took part…

This study looked at how a two-month exercise program changes the way the body processes different types of dietary fats in men with obesity. Twelve men aged 18 to 55 who were overweight but not extremely obese took part. Researchers measured fat oxidation and gene expression in …

This study looked at how moving your head backward or turning it left or right changes the pressure under your feet while standing still. 87 healthy adults aged 18 to 30 stood on a pressure-measuring platform and held different head positions for two minutes each. The goal was to…

This pilot study tested a smartphone app designed to help patients manage medications that are taken only when needed after surgery. The app gives recommendations based on symptoms and prescriptions. Researchers compared the app's advice to recommendations from a healthcare profe…

This study tested a noninvasive navigation system that measures how the knee moves before surgery. Researchers hope that by understanding each patient's unique knee motion, doctors can better plan knee replacement surgeries. The study involved 40 adults with end-stage knee osteoa…

This study looked at how the heart and lungs of 10 people with moderate COPD respond during a 30-minute exercise test with short bursts of hard work. Researchers found that lung blood pressure did not rise dangerously and heart output stayed steady after the first 5 minutes. The …

This study looked at how people with schizophrenia organize memories of everyday events. About 80 participants, including patients and healthy volunteers, took a 1-hour walk in Strasbourg while wearing an automatic camera. Later, they were asked to put photos from the walk in the…

This study looked at how the body naturally stops allergic inflammation after being exposed to grass pollen. Researchers measured specific molecules in the nose that help control and resolve the allergic response. Twenty adults with grass pollen allergies participated. The goal w…

This study looked at 80 patients who had surgery to treat an infection in a hip or knee replacement. The goal was to see if giving antibiotics before taking tissue samples during surgery changes the test results for infection. The researchers compared samples taken before and dur…

This study looked at how well-trained runners' hearts and lungs respond when running on a treadmill at different slopes: uphill, flat, and downhill. Eight athletes completed tests to measure their peak oxygen uptake and muscle fatigue. The goal was to see if downhill running uses…

This study followed 77 patients under 60 who had a mechanical aortic valve replacement to see if a mismatch between the valve size and the patient's body affects heart recovery and exercise ability. Participants did exercise tests and heart ultrasounds years after surgery. The go…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study looked at 60 patients who had a single surgery to replace an infected knee implant. Researchers wanted to see if carefully selecting patients based on factors like age, infection duration, and bacteria type could improve healing. The goal is to find out if a one-step p…

This study looked at whether a memory technique called 'retrieval practice' works in people with schizophrenia. Participants studied word pairs and were later tested or re-studied them. The goal was to see if testing improves recall more than re-studying. 40 people took part, inc…

This completed study looked at 500 patients who had abdominal wall prosthesis infections after hernia surgery. Researchers aimed to identify risk factors, common germs, and what helps patients recover. The goal is to improve how these serious infections are treated.

This study looked at how exposure to white light at different times of day affects sleep quality, brain waves, and mental performance in 92 healthy adults aged 18 to 40. Participants were monitored using EEG and various thinking tests. The goal was to understand light's influence…

This completed study looked at how doctors at Strasbourg University Hospital treat acute shoulder dislocations in the emergency department. Researchers reviewed the care given to 238 adult patients, focusing on pain relief methods used before the shoulder is put back in place. Th…

This study looked at how different light conditions affect tiredness and mental performance in healthy adults after staying awake all night. 18 volunteers aged 18-40 were monitored for fatigue, hormone levels, and cognitive test results. The goal was to better understand sleep lo…

This study looked at gene activity in B cells (a type of immune cell) from 30 people with non-active systemic lupus erythematosus and compared it to healthy donors. The goal was to find what makes lupus B cells different, even when the disease is quiet. No treatment was given; it…

This study followed 300 people who had a blood clot in a vein (deep vein thrombosis or pulmonary embolism). Researchers tracked how often clots came back, bleeding complications, and how well different treatments worked. The goal was to learn more about why clots happen and impro…

This study looked at sleep problems in 37 adults with non-small cell lung cancer. Researchers used questionnaires to measure sleep quality and plan to create a guide to help doctors diagnose and treat these sleep issues. The goal is to improve quality of life for people with lung…

This study looked at how two anxiety medications, lorazepam and diazepam, affect memory and brain activity in 22 healthy young adults. Participants took a single dose of one drug and then performed memory tasks while their brains were scanned using fMRI. The goal was to understan…

This study looked at how the brain creates the feeling of being in control of our own actions. Researchers compared healthy volunteers with people who have schizophrenia or bipolar disorder, especially those who feel their actions are controlled by an outside force. The goal was …

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find which toxins (harmful substances) the bacteria produce that lead to serious illnesses like blood infections or heart valve infections. Researchers compared samples from patients with differen…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This study looked at how autism affects a person's sense of self in adulthood. Researchers asked 102 adults (some with autism, some without) to recall personal memories and describe what defines them. The goal was to understand differences in memory detail and self-concept, witho…

This study tested whether custom-made cutting guides, created from each patient's CT scan, can improve the accuracy of knee replacement surgery. Researchers enrolled 20 adults with end-stage knee osteoarthritis to see if these guides lead to better implant positioning. The goal i…

This study looked at how people with dementia with Lewy bodies experience their sense of self, including memory and self-concept. Researchers compared 61 participants with dementia, Alzheimer's, and healthy aging using memory tests and brain scans. The goal was to understand whic…

This study looked at whether a simple blood test can monitor lung cancer progression without needing to sample the tumor directly. Researchers checked for genetic changes in the blood of 200 lung cancer patients. The goal was to see if this non-invasive method could track how the…

This study tested whether medical students who practiced lumbar punctures on an augmented reality simulator performed better on real patients than those who learned the usual way. Sixty patients needing a lumbar puncture took part. The simulator uses haptic feedback to mimic the …

This study aims to establish normal values for a breathing test called the interrupter technique in healthy adults. The test requires very little cooperation from the patient, making it ideal for people who have difficulty performing standard lung function tests. Researchers meas…

This study looked at 30 adults having major spine surgery to see how a lung-opening technique (alveolar recruitment maneuver) affects breathing and blood flow when done in the usual face-down position versus lying on the back. The goal is to learn which position is safer and help…

This study aims to create a reference set of normal nerve fiber density values in the skin of healthy adults. By measuring these fibers in 300 people without pain or nerve problems, researchers hope to improve the accuracy of diagnosing small fiber neuropathy. The results will he…

This study looked at a newer way to take prostate tissue samples using MRI guidance through the perineum (the area between the scrotum and anus) instead of the standard method through the rectum. The goal was to see if this approach causes fewer complications and hospital readmis…

This study tested how accurately an ultrasound fusion system can guide a needle into a tissue lesion. Researchers compared the planned needle path shown by the system to the actual path seen on a CT scan. The goal was to see if this method is more precise than using ultrasound or…

This study looked at 88 people aged 11 or older who finished braces and got a permanent wire glued behind their lower front teeth to keep them straight. Researchers compared two ways of preparing the teeth before gluing: sandblasting the enamel versus cleaning with pumice. The go…

This study looked at 27 adults with a severe immune system problem called Common Variable Immune Deficiency (CVID), who also had low white blood cells (neutropenia) and swollen lymph nodes (lymphoproliferation). The goal was to find gene changes that might cause these severe symp…

This study looked at 10 people with liver cancer (HCC) who were getting a standard treatment called chemoembolization (c-TACE). The goal was to see if mixing the chemotherapy drug doxorubicin with salt water or a contrast dye changes how the drug spreads inside the tumor. Researc…

This study looked at how deaf people who were born deaf process reading in their brains. Researchers used brain scans to compare deaf and hearing readers. The goal was to understand how the brain adapts to reading without ever hearing speech sounds. 60 adults who are deaf and hav…

This study looked at 300 adults having outpatient surgery to see how often a condition called akathisia (a feeling of severe restlessness) occurs with two different anti-nausea drugs: Droperidol and Ondansetron. The goal was to find out if Droperidol causes more akathisia than On…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to see if…

This study looked at how many hospital workers in Strasbourg, France, had antibodies against the virus that causes COVID-19. About 1,466 staff members were tested to see if they had been infected, especially after a large outbreak linked to a religious event. The goal was to unde…