University Hospital, Strasbourg, France

This study tested a light-based treatment called FOTOSAN® for severe gum disease (periodontitis) in 36 adults aged 40 and older. The goal was to see if adding this photodynamic therapy to standard care could reduce deep gum pockets and infection over 6 months. The treatment uses …

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF biologic stopped working. Researchers compared two options: switching to a different anti-TNF or changing to a biologic with a different mechanism. The goal was to see which strategy better cont…

This early-phase study tested a combination of two drugs, rapamycin and irinotecan, in 42 children and young adults (ages 1-21) with solid tumors that did not respond to standard treatments. The main goal was to find the safest dose and understand side effects. The approach aims …

This study tested a freezing technique called cryoablation on 50 people with rare, non-cancerous but painful desmoid tumors that continued to grow despite standard treatments like anti-inflammatories or chemotherapy. The goal was to freeze the tumor to stop its growth and relieve…

This study looked at whether giving a special plasma product (OctaplasLG) to people with septic shock and blood clotting problems is helpful. 60 adults took part. The goal was to see if this treatment could improve clotting and reduce inflammation, but it is not a cure — it aims …

This study looked at 60 obese adults having heart surgery with a heart-lung machine. It compared two ways of giving the blood thinner heparin: one based on total body weight and one based on ideal body weight. The goal was to see if using ideal body weight prevents giving too muc…

This early-phase study tested a special artificial larynx with valves in 10 adults who had severe swallowing troubles, often after laryngeal cancer. The goal was to see if the device could help them close their tracheotomy (if they had one) and restore safe swallowing. The study …

This study looked at whether carefully selecting patients helps heal infections after a one-step knee replacement change. Researchers reviewed 60 patients who had this surgery between 2000 and 2010. The goal was to see if using specific patient criteria (like age, infection type,…

This early-phase study tested a new approach for people with stage IIIB/C melanoma that has spread to lymph nodes. Doctors used a freezing technique (cryotherapy) to destroy tumor cells, then injected the immunotherapy drug ipilimumab directly into the treated area, plus gave a f…

This study looked at whether adding the drug vildagliptin to insulin can help control blood sugar in people with type 2 diabetes who are on dialysis. 70 adults on dialysis took part. The researchers used continuous glucose monitoring to track blood sugar levels over 12 weeks. The…

This study looked at 88 people aged 11 and older who finished braces and got a permanent wire glued behind their lower front teeth to keep them straight. Researchers compared two ways of preparing the teeth before gluing: sandblasting the enamel versus the usual pumice polishing.…

This study tested a new way to rebuild the front part of the jaw after surgery using a porous titanium implant. The goal was to avoid more complex bone grafts that often cause problems. Seven adults took part, and the implant was designed to be quick and easy to fix in place. The…

This study tested a new method (SRM-MS/MS) to diagnose Lyme disease from skin samples. It included 84 people with early Lyme skin rash (erythema migrans). The new method was compared to standard lab tests to see which detects the bacteria best.

This study tested a new way to take prostate tissue samples using MRI guidance through the perineum (the area between the scrotum and anus). The goal was to see if this method causes fewer complications and is more comfortable for patients than the standard biopsy through the rec…

This study looked at 200 pregnant women who needed a planned C-section. One group had the C-section at 38 weeks after receiving two steroid shots to help the baby's lungs. The other group had the C-section at 39 weeks without steroids. The goal was to see if the earlier, steroid-…

This study tested four different ways of preparing the carbon dioxide gas used during laparoscopic (keyhole) womb surgery. The goal was to see if warming, wetting, or adding numbing medicine to the gas could prevent the patient's body temperature from dropping and reduce pain aft…

This study looked at whether laparoscopic promontofixation, a common surgery for pelvic organ prolapse, can be safely performed as an outpatient procedure. Researchers enrolled 60 women and tracked how many needed to be readmitted to the hospital after going home the same day. Th…

This study looked at a different way to manage pain after chest surgery (thoracotomy) for patients who cannot have an epidural. The surgeon placed a small tube near the spine to deliver numbing medicine for 48 hours, and all patients also received morphine through a pump. The goa…

This study tested a connected device called the EMY biofeedback probe to help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). The goal was to see if using the probe improves quality of life. Fifty-five women who had given birth at le…

This study tested whether a special germ-trapping dressing (Sorbact) helps wounds heal faster after surgery for pilonidal sinus, a painful condition near the tailbone. About 250 adults took part, and researchers compared Sorbact to a standard dressing over 75 days. The goal was t…

This study compared a newer device called a morcellator with a standard resectoscope for removing uterine polyps in 90 women. The goal was to see which tool works faster and causes fewer complications. The morcellator may offer benefits like smaller size, better vision, and less …

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling or shopping. 117 adults with Parkinson's and moderate-to-severe impulse issues took the drug or a placebo for 8 weeks. …

This study tested a 5-month program called Dialectical Behavior Therapy (DBT) for adults with autism who have trouble managing emotions and may harm themselves. 92 adults without intellectual disability took part. The goal was to see if DBT could reduce emotional distress and sel…

This study looked at how moderate physical activity influences the way the body processes different types of dietary fats in men with obesity. Twelve men aged 18 to 55 with a BMI over 25 and a sedentary lifestyle participated. They underwent tests before and after two months of e…

This study aims to establish what normal nerve fiber density looks like in healthy adults aged 20 to 80. By taking small skin samples from 300 volunteers without pain or nerve problems, researchers hope to create a reference range that can help doctors better diagnose small fiber…

This study looked at how many hospital workers in Strasbourg, France, had antibodies against the virus that causes COVID-19. Over 1,400 staff members were tested to see if they had been infected and developed immune defenses. The goal was to understand how far the virus spread am…

This study looked at how the body naturally stops allergic inflammation after being exposed to an allergen. Researchers measured specific molecules in the nose to understand the timing of this process. 20 adults with grass pollen allergies participated. The goal was to learn more…

This study looked at 77 patients under 60 who had a mechanical aortic valve replacement. Researchers wanted to see if a mismatch between the valve size and the patient's body affects heart remodeling and exercise capacity years later. Participants did stress tests and heart ultra…

This study tested a noninvasive navigation system to measure how the knee moves in people with severe knee osteoarthritis before they get a knee replacement. The goal was to see if measuring knee motion could help doctors better match implants to each patient's anatomy. 40 adults…

This study looked at how dementia with Lewy bodies affects a person's sense of self, including memory and self-concept. Researchers compared 61 older adults with dementia, Alzheimer's, or normal aging using memory tests and brain scans. The goal was to understand which brain chan…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, could be used as biomarkers to help diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to…

This study looked back at how 238 adults with a dislocated shoulder were treated in the emergency room at Strasbourg University Hospital. The goal was to find ways to reduce pain during the procedure to put the shoulder back in place. Researchers will use what they learned to cre…

This study tested whether training with an augmented reality simulator helps medical students perform their first lumbar puncture (a needle procedure to collect spinal fluid) more successfully than standard teaching. Sixty patients needing a lumbar puncture took part. The goal wa…

This study tested a smartphone app designed to help patients manage their medications after surgery. The app gave recommendations on which drugs to take and when. Researchers compared the app's advice to recommendations from a nurse to see if they matched. The study involved 37 a…

This study reviewed the medical records of 500 adults who had hernia repair surgery with a mesh implant. The goal was to learn more about infections that can happen after this surgery, including what germs cause them and what factors make them more likely. By understanding these …

This study measured normal breathing resistance in 122 healthy, non-smoking adults using a simple technique that requires little cooperation. The goal was to establish reference values for this method, which may be especially useful for people who have difficulty performing stand…

This study followed 300 people who had a blood clot in a vein (deep vein thrombosis or pulmonary embolism) to see how often clots come back or cause bleeding. Researchers wanted to find new risk factors and compare newer blood thinners to older ones. The study did not test a new …

This study looked at how people with schizophrenia organize memories of everyday events. Participants took a 1-hour walk in the city while wearing an automatic camera around their neck. Later, they were shown pictures from the walk and asked to put them in the correct order and i…

This study looked at 30 adults having major spine surgery to see how a breathing technique called alveolar recruitment maneuver (ARM) affects the lungs and heart when done in different body positions. ARMs help keep lungs open during surgery. The researchers compared doing ARM wh…

This study looked at how the brain creates the feeling of being in control of our own actions. Researchers compared healthy volunteers with people who have schizophrenia or bipolar disorder, especially those who feel their actions are controlled by an outside force. By studying s…