New drug cocktail shows promise for kids with resistant cancers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>= 1 year old and =\< 21 years old; * Refractory solid tumors, histologically proven at diagnosis (no additional biopsy needs to be performed for the purpose of the study); * Relapsed or refractory solid tumors after standard treatment or phase II, III-IV clinical trials treatment have failed; * Karnofsky or Lansky status \>= 70%; * Life expectancy \>= 8 weeks; * No chemotherapy / radiotherapy within 4 weeks before entry into the study; * Adequate biological parameters : * Absolute neutrophil count \>= 1.0 x 109/L; * Platelet count \>= 100 x 109/L; * Hemoglobin \>= 8 mg/dL; * Total bilirubine =\< 1.5 ULN; * Transaminases =\< 2.5 ULN (=\< 5 ULN in case of liver metastases); * Creatinine clearance (Cockroft) \>= 70 mL/min/1.73 m2; * Normal coagulation profile with prothrombin \>= 70%, TCA =\< 35 and fibrinogen \>= 2 g/L; * Patients with 1 to 3 previous therapeutic lines are eligible; * No current grade \>= 2 organ toxicity based on NCI-CTCAE version 3.0; * All patients with reproductive potential must have an effective method of birth control while on study; * Negative pregnancy test in females when indicated; * Informed written consent signed by patients or their parents or legal guardians; * Patient who was informed of the results of prior medical consultation; * Patient having a social insurance. Exclusion Criteria: * Patient with a constitutional anomaly of coagulation and/or of hemostasis (type hemophilia, von Willebrand disease, congenital clotting factor deficit, platelet disorder), exposing them to increased risk of bleeding; * Pre-treatment with a mTOR inhibitor; * Other simultaneous malignancy; * Concurrent administration of any other anti-tumour therapy; * Known hypersensitivity or contraindication to study drugs or ingredients; * Severe concomitant disease (e.g. infection disease); * Patient unable for medical follow-up; * Pregnancy and/or lactation; * Patient included in another clinical drug trial; * Patient taking drugs interfering with pharmacology of rapamycin and/or irinotecan (e.g. drugs interfering with CYP3A4); * Patient under judicial protection.