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Heart transplant hope: amino acid boosts exercise and kidneys?

NCT ID NCT00213915

Disease control Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking L-arginine, a natural amino acid, for six weeks could improve exercise ability and kidney function in heart transplant recipients. Thirty stable male patients took the supplement twice daily. The goal was to see if it helps with common post-transplant problems like poor exercise capacity and kidney damage from anti-rejection drugs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
L-arginine (an amino acid supplement)
What this could lead to
If it works, this could point toward a simple supplement to help heart transplant patients exercise better and protect their kidneys.
What could go wrong
This is a small, completed phase 4 trial with only 30 men, so results may not apply to everyone. L-arginine may not improve outcomes and could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

30 people

Started

Feb 2004

Finished

Dec 2004

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male (\> 18 years old) stable heart transplant recipient for at least 6 weeks * Stable treatment for at least 3 months * Sedentary people Exclusion Criteria: * Unstable cardiac pathology * Obesity (IMC \> 40) * Participation in another study in the last month * Chronic renal failure (creatinine clearance \< 20 ml/min) * Renal transplantation * Diabetes * Impossibility to practice exercise test * Nitrate therapy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart transplantation

Contacts and locations

Locations

  • Institut de Physiologie

    Strasbourg, 67091, France

  • Service de Chirurgie Vasculaire

    Strasbourg, 67091, France

  • Service des Explorations Fonctionnelles Respiratoires et de l'Exercice

    Strasbourg, 67091, France

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