University Hospital, Strasbourg, France

This study tests whether dapagliflozin, a diabetes drug, can improve survival and organ function in people with septic shock who have poor blood flow in small vessels. About 568 adults in the ICU will receive either the drug or a placebo, plus standard care, for up to 28 days. Th…

This study tests a drug called sivelestat in people with septic shock who also have a blood clotting problem called coagulopathy. The drug aims to help the body break down small blood clots that form during severe infections. About 120 adults in intensive care will receive either…

This study compares two surgical approaches for people with early-stage, high-risk endometrial cancer that has a p53 gene mutation. Half of the 374 participants will receive the standard extensive lymph node removal, while the other half will get a less invasive sentinel node bio…

This study will test whether measuring a specific form of the protein alpha-synuclein in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Currently, misdiagnosis is common and can be dangerous because many DLB patients have severe re…

This study tests whether treating a first-time collapsed lung (pneumothorax) at home, instead of in the hospital, improves quality of life. About 386 adults aged 18-50 will be randomly assigned to either outpatient care or standard inpatient care. The main goal is to see how each…

This study explores whether using a virtual reality (VR) headset can help reduce pain, anxiety, and fatigue in people receiving palliative care. Forty adults with complex needs will be randomly assigned to either an immersive VR experience or a less immersive control for 10 minut…

This study tests whether combining hypnosis with aromatherapy (using scents as anchors) can reduce anxiety in people going through alcohol withdrawal. Researchers will compare this approach to standard care in 80 hospitalized adults. The goal is to see if the combination provides…

This study looks at whether Dialectical Behavior Therapy (DBT) — a type of talk therapy that teaches skills to handle emotions — can help people with addiction who also have trouble managing their feelings. About 120 adults will be split into three groups: in-person DBT, online D…

This study explores whether using interactive virtual reality (VR) can help reduce pain, anxiety, and fatigue in people receiving palliative care. Twenty hospitalized adults with a life expectancy of at least one month will try daily VR sessions for two weeks. The goal is to see …

This study tests a new DNA-reading technology called long-read genome sequencing in 20 children with severe epilepsy whose standard genetic tests came back normal. The goal is to find hidden genetic errors that standard methods miss. If successful, this could lead to personalized…

This study compares 3D models made from CT scans without contrast dye to standard 2D contrast CT scans for planning minimally invasive lung surgery. Researchers want to see if the 3D approach is just as accurate at showing blood vessels, airways, and tumor location. About 50 adul…

This study looks at how autistic women experience emotional ups and downs during their menstrual cycle, especially around their period. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any diagnosed co…

This study tests whether a personalized follow-up program, guided by patients' own reports of how they feel, can improve recovery after complex surgery. Researchers will enroll 276 adults with complex care needs and compare standard care to the new program. The goal is to see if …

This observational study will measure the level of a protein called GLP1 receptor on blood cells from 50 adults with peripheral artery disease (PAD). The goal is to see if this receptor is linked to disease severity and inflammation, which could mean that existing GLP1 agonist dr…

This study will follow 100 adults in intensive care who need ECMO, a machine that helps the heart and lungs. The goal is to see if changes in a blood marker called D-dimer can warn doctors about serious bleeding risks within 24 hours. By finding a clear threshold, the study hopes…