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New spinal fluid test aims to distinguish lewy body dementia from Alzheimer's

NCT ID NCT07166744

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 25 times

Summary

This study will test whether measuring a specific form of the protein alpha-synuclein in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Currently, misdiagnosis is common and can be dangerous because many DLB patients have severe reactions to certain medications. The study plans to enroll 286 adults aged 50 and older who show signs of either condition, and will compare the new test results against standard diagnostic methods.

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