Sun Yat-sen University

This study tests a new pre-mixed fluid that contains phosphate for ICU patients needing continuous kidney dialysis (CRRT). Normally, this treatment can wash out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the standard one in …

This study tests whether combining two drugs, scipibaimab and tislelizumab, can shrink tumors or slow cancer growth in people with advanced nasopharyngeal cancer that got worse after standard first treatment. About 37 adults aged 18-75 will receive the combo. The goal is to see h…

This study tests whether adding entinostat to fulvestrant can help control advanced breast cancer in people whose disease worsened after CDK4/6 inhibitor and hormone therapy. About 50 women with HR+/HER2- breast cancer will receive the combination. The main goal is to see how lon…

This study tests a combination of three drugs (sonrotoclax, zanubrutinib, and rituximab) as a first treatment for people with follicular lymphoma, a slow-growing blood cancer that is not currently curable. The goal is to see if this chemotherapy-free approach can shrink tumors co…

This study tests whether giving a combination of surufatinib (a targeted therapy), toripalimab (an immunotherapy), and chemotherapy before surgery can help people with high-risk or borderline resectable pancreatic cancer. About 30 adults aged 18-75 will receive up to 8 cycles of …

This study tests whether adding a second drug (rhTPO) to hetrombopag works better than hetrombopag alone for cancer patients whose platelets drop dangerously low after treatment. About 204 adults with solid tumors will receive either the combination or the single drug for up to 1…

This study compares two treatments for small liver cancer (up to 5 cm): surgery to remove the tumor versus a precise, non-invasive radiation therapy called SBRT. About 312 adults with a single small liver tumor will be randomly assigned to one of the two treatments. The goal is t…

This study tests a combination of three drugs (chidamide, toripalimab, and anlotinib) in people with nasopharyngeal cancer that has come back or spread and hasn't responded to at least one prior treatment. The goal is to find the safest dose and see how well the drugs shrink tumo…

This study tests a three-drug combination (QL1706, lenvatinib, and nab-paclitaxel) in 47 people with advanced penile cancer that has come back or not responded to prior treatment. The goal is to see if the combination can shrink tumors or slow cancer growth. All participants rece…

This study tests whether adding lubiprostone, a drug used for constipation, to standard maintenance therapy can delay cancer recurrence in people with colorectal cancer that has spread to the lining of the abdomen. About 124 adults who have had surgery to remove visible cancer wi…

This study tests a new treatment approach for people with high-risk locally advanced rectal cancer. It combines a short course of radiation (with a boost to the tumor) with chemotherapy and an immunotherapy drug before surgery. The goal is to see if this combination can make tumo…

This study tests a combination of three drugs (disitamab vedotin, tunlametinib, and a PD-1 antibody) in people with advanced stomach cancer that has a specific protein (HER2) and has not responded to at least two prior treatments. The goal is to see if this combination can shrink…

This study tests a new treatment for people with advanced digestive tract cancers that cause fluid buildup in the belly (malignant ascites) after standard treatments have stopped working. The treatment combines a modified protein (rmhTNF-NC) injected into the belly, an immunother…

This study tests whether adding the targeted drug fruquintinib to standard chemotherapy helps shrink tumors and delay cancer growth in people with advanced pMMR endometrial cancer. About 128 adults aged 18-75 with stage III/IV or recurrent disease will be randomly assigned to rec…

This study looks at whether giving radiation therapy after surgery can help prevent cancer from coming back in people with high-risk adrenocortical carcinoma, a rare adrenal gland cancer. About 58 adults who had their tumor completely removed will be randomly assigned to either r…

This study tests a new flexible sheath (ArcFlex) used during TAVR, a procedure to replace a diseased aortic heart valve. The sheath helps guide the new valve into place. The trial will include 180 people who need TAVR and will check if the sheath works safely and effectively. The…

This study tests a new drug combination (goselasib plus other treatments) as a first-line therapy for people with a specific genetic mutation (KRAS G12C) in advanced or metastatic non-small cell lung cancer. About 69 adults who have not had prior treatment for their advanced canc…

This early-phase study tests a personalized cell therapy (TCR-T) in 25 adults with advanced solid tumors caused by KRAS mutations, such as certain colorectal and lung cancers. The treatment involves collecting the patient's own immune cells, engineering them to better recognize a…

This study tests a new approach for people with early-stage lung cancer who cannot or do not want chemotherapy. Before surgery, patients receive a short course of focused radiation (SBRT), an immunotherapy drug (tislelizumab), and an antiangiogenic drug (anlotinib) to shrink the …

This phase 2 trial tests whether adding trilaciclib to the chemotherapy drug eribulin can protect bone marrow in people with advanced triple-negative breast cancer who have already tried at least two prior chemotherapies. The study will measure how well the combo reduces severe l…

This study looks at 120 people with advanced liver cancer caused by hepatitis B who are also getting immunotherapy. It compares two antiviral drug plans: one using TAF alone, and the other using TAF plus ETV. The goal is to see which plan helps people live longer and better contr…

This study tests whether adding the arthritis drug celecoxib to standard chemotherapy (R-CHOP) works better than chemotherapy alone for people with a rare, aggressive form of lymphoma called CD5-positive diffuse large B-cell lymphoma. About 60 adults with newly diagnosed advanced…

This study is testing a virtual companion that talks with teenagers who have gone through stressful life events. The goal is to see if these conversations can help reduce emotional symptoms and build resilience. About 35 teens aged 14-25 will use the virtual agent for 4 weeks, an…

This study tests whether text message reminders, a medication calendar, and a personal action plan can help people with atrial fibrillation take their blood-thinning medication more consistently. Researchers will compare 84 participants who receive these nudges against those who …

This study tests whether adding a small dose of morphine into the spinal fluid (intrathecal morphine) to a standard abdominal wall nerve block can improve recovery after laparoscopic gynecologic surgery. About 252 women scheduled for this surgery will be randomly assigned to rece…

This study tests a 12-week home-based exercise program for adults aged 60+ with type 2 diabetes and early muscle weakness (probable sarcopenia). Participants will do short bouts of aerobic and resistance exercises to see if it improves their physical activity levels and muscle st…

This phase 3 trial tests whether megestrol acetate, given at the start of T-DXd treatment, can prevent or lessen fatigue in 132 women with advanced breast cancer. Fatigue is a common side effect of T-DXd, and the study measures changes in fatigue scores and quality of life. Parti…

This study looks at how the amount and type of carbohydrates you eat affect your blood sugar, cholesterol, and gut bacteria. Researchers will give 20 adults with or at risk for metabolic syndrome different carb diets and measure changes. The goal is to understand how carbs impact…

This study looks at two ways to place a special tube (called a PICC) in cancer patients who need long-term medicine. One method uses magnetic tracking, the other uses heart signals (ECG). The goal is to see which method is faster, more accurate, and causes fewer problems like inf…

This study involves 100 adults with NK/T-cell lymphoma who are about to start their first treatment. Researchers will use artificial intelligence to analyze medical images and tissue samples to predict whether the cancer will respond well to therapy. The goal is to create a tool …

This study looks at 120 adults with central serous chorioretinopathy (CSC), an eye condition that causes fluid buildup and vision problems. Researchers will use a special type of eye scan called ultra-widefield OCTA to measure blood vessel patterns and fluid levels. The goal is t…

This study tests a 4-week online program designed to help parents of children aged 3-6 support healthy behaviors like physical activity, less screen time, handwashing, and reducing sugary drinks. Researchers will compare parents who get the program right away to those on a waitli…