Could a single spinal shot ease pain and speed recovery after major abdominal surgery?
NCT ID NCT07575321
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of morphine given into the spinal fluid before open abdominal surgery can improve how well patients recover. It involves 756 adults scheduled for surgery and compares the spinal injection to a placebo. The goal is to see if this approach reduces pain and helps patients get back on their feet faster.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 756 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 18 years. 2. Scheduled for elective open abdominal surgery (upper or lower abdomen). 3. American Society of Anesthesiologists classification I-III. 4. Signed informed consent form. Exclusion Criteria: 1. Allergic to opioids or any drug in the trial. 2. Presence of contraindications to intrathecal injection (such as abnormal coagulation function, puncture site infection, increased intracranial pressure). 3. History of chronic pain, long-term use of opioids. 4. Severe hepatic and renal insufficiency (Child-Pugh C grade or eGFR \< 30 mL/min). 5. Severe respiratory diseases (such as non-invasive ventilation required for sleep apnea syndrome). 6. Cognitive dysfunction, unable to complete the questionnaire. 7. Pregnant or lactating women. Withdrawal criteria: 1. The patient or legal representative requests withdrawal. 2. Serious complications occur during the study, and continued participation is not in the best in-terest of the patient. 3. Other situations where the researcher believes withdrawal is necessary.
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As listed by the trial registrant
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How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
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A doctor treating you
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