Icahn School Of Medicine At Mount Sinai

This phase 2 trial tests a combination of hormone therapy (Lupron), an androgen blocker (Darolutamide), and an immunotherapy (Pembrolizumab) given before and after prostate removal surgery in 40 men with high-risk prostate cancer. The goal is to see if this approach can reduce or…

This study tests two drugs, abemaciclib and bicalutamide, together in people with a certain type of advanced breast cancer (androgen receptor-positive, HER2-negative) that has spread. The goal is to find the best dose and see if the combination is safe and can control the disease…

This study tests low-dose methotrexate, a common arthritis drug, in 54 people with three rare blood cancers: polycythemia vera, essential thrombocythemia, and myelofibrosis. Researchers want to see if it can shrink spleens, improve symptoms, and lower blood counts safely. If succ…

This study is testing whether a simple, standard prevention plan works as well as a personalized one for people who get calcium oxalate kidney stones. 80 participants will either receive a diuretic and diet advice based on their stone type alone, or have their treatment guided by…

This study tests whether the drug ritlecitinib can prevent keloids from returning after surgical removal. Keloids are raised, often itchy scars that grow beyond the original wound. The trial will enroll 30 adults who will take a daily pill for 36 weeks. Researchers will measure k…

This early-stage study tests whether MDMA-assisted therapy can help people with bulimia nervosa. Forty adults will be assigned to one of three groups: standard therapy, MDMA with general therapy, or MDMA with bulimia-specific therapy. The MDMA groups include three medicine sessio…

This study is testing a special catheter called IRRAflow that both drains fluid and actively irrigates the brain to remove blood after a hemorrhage. The trial will compare this device to standard catheters in 17 adults with intraventricular hemorrhage. Researchers want to see if …

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This pilot study tests a topical cream called delgocitinib in 30 adults with two types of scarring hair loss: lichen planopilaris and central centrifugal cicatricial alopecia. Participants apply the cream twice daily for 48 weeks. The study focuses on safety and changes in immune…

This study looks at whether community health workers can help emergency department patients with high blood pressure connect to local resources that address their social needs, like food or housing. Fifteen adults with uncontrolled hypertension will complete surveys and receive r…

This study tests a 'Metabolic Diet' designed to help women with anorexia nervosa maintain a healthy weight after they have regained weight. Twenty adult women who recently reached a normal weight will follow the diet with a dietitian's help for 10 weeks. Researchers will monitor …

This early-stage trial is testing a new drug, alnuctamab, in 21 people with moderate to severe lupus that hasn't improved with standard treatments. The drug is given as an injection under the skin, and participants will stay in the hospital for 9 days after the first dose. The ma…

This study looks at whether adding a blood thinner to standard antiplatelet therapy can prevent strokes and other blood clots in people who develop a new irregular heartbeat (atrial fibrillation) after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and …

This study tests an oral drug called reparixin in 26 adults with high-risk myelofibrosis who cannot take or refuse standard JAK inhibitor therapy. The goal is to see if reparixin can shrink the spleen, improve anemia, and reduce symptoms over 6 months. Participants who respond we…

This study tests whether adding a coping skills program to standard biologic medication helps people with early Crohn's disease (diagnosed less than 5 years) feel better emotionally and achieve remission. About 170 adults with active Crohn's will be randomly assigned to receive e…

This study tests whether personalized home-based coaching can help people with COPD better manage their symptoms and avoid hospital visits. Researchers will enroll 300 adults from diverse backgrounds in New York City. Participants will receive support from health coaches, includi…

This study tests whether a low dose of sirolimus (rapamycin) can improve quality of life in adults with Long COVID. Eighty participants will receive either the drug or a placebo for several months. The goal is to see if sirolimus reduces symptoms like fatigue and brain fog, helpi…

This phase 3 trial tests whether adding cannabidiol (CBD) to standard opioid addiction treatment can reduce cravings and prevent relapse. About 450 adults with opioid use disorder who are already on methadone or buprenorphine will receive CBD or a placebo for 24 weeks. The goal i…

This study looks at whether community health workers and special training for doctors can help more people with advanced kidney disease get on the waiting list for a kidney transplant. About 5 patients will take part, and their doctors will be randomly assigned to either offer th…

This study looks at whether following the MIND diet—a mix of Mediterranean and DASH diets—can improve brain health and reduce symptoms in people with multiple sclerosis (MS). About 100 adults with MS will either follow the MIND diet for one year or continue their usual eating hab…

This study tests a combination of two drugs, sacituzumab govitecan and cisplatin, in people with ovarian or endometrial cancer that has come back but still responds to platinum-based treatments. The goal is to find the safest dose and see how well the drugs shrink tumors. About 5…

This study tests whether combining two drugs (atezolizumab and bevacizumab) with a type of internal radiation (Y-90) can shrink liver tumors enough for patients to become eligible for a liver transplant. About 40 adults with hepatocellular carcinoma (HCC) will receive this combin…

This study tests if dupilumab can help children aged 6 to 17 with moderate to severe alopecia areata regrow hair. About 76 participants will receive either the drug or a placebo for 48 weeks, followed by an open-label extension. The main goal is to measure changes in scalp hair l…

This study tests an oral medication, deucravacitinib, in 20 adults with two types of scarring hair loss (CCCA and FFA). Participants take one pill daily for 48 weeks. The goal is to see if the drug reduces inflammation and scarring in the scalp, potentially stopping hair loss pro…

This study tests if rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after bladder cancer surgery can prevent urinary tract infections. About 23 adults having bladder removal and reconstruction will participate. The main goal is to see if urine is…

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This study tests two treatments—MTC01 and FMT—for people with repeat C. diff infections. About 60 adults will receive one of four treatment options. The main goal is to check safety and see how well each treatment prevents the infection from coming back within 8 weeks.

This study tests a daily pill called abrocitinib for people with Down syndrome who have eczema or a type of hair loss. About 56 participants will take the drug for up to 60 weeks to see if it safely controls their skin or scalp condition. The goal is to manage symptoms, not cure …

This study tests a new upright MRI scanner for prostate cancer screening in 550 men at risk. It compares the upright MRI to standard PSA tests and traditional MRI to see if it's more comfortable and effective. Participants will also fill out questionnaires about their comfort dur…

This study is testing whether a simple 3-ounce water swallow test can accurately detect aspiration (liquid going into the airway) in people with tracheostomies. Researchers will compare the water test results with standard swallow exams like FEES or modified barium swallow. The g…

This study looks at whether a special PET/CT scan (rhPSMA-7.3) can find more aggressive prostate cancers than standard MRI in men with low-risk cancer who are not yet getting treatment. About 120 men will get both scans before a biopsy to see which method works better. The goal i…

This study checks if a continuous glucose monitor (CGM) worn on the skin can accurately diagnose gestational diabetes in pregnant people. About 150 participants will wear the monitor and also take the standard glucose drink test to compare results. If the CGM works well, it could…

This study tests a new FDA-approved scanner that gives doctors a fast, detailed view of the prostate surface during surgery to find leftover cancer cells. The goal is to see if this method saves at least 20 minutes compared to the current technique. About 78 men with intermediate…

This study tests a new way to check for bleeding after stroke surgery using a special ultrasound through a clear skull implant. It aims to see if this method is as accurate as a CT scan, which is the current standard but is expensive and time-consuming. About 25 adults who had a …

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has early-stage dementia. The program is designed to help both partners manage emotional distress after a recent diagnosis. The study will include 24 couples and …

This study tests a web-based program called webSTAIR, which teaches emotion regulation and relationship skills, for female veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see if it helps them manage em…

This study tests a type of talk therapy called Meaning-Centered Psychotherapy for Caregivers (MCP-C) to see if it helps cancer caregivers feel more purpose and less distress. About 200 caregivers of people with advanced cancer will be randomly assigned to MCP-C or standard suppor…

This pilot study tests whether a community navigator can help Black and Latina women with metastatic breast cancer access supportive care and community resources. Participants receive six coaching sessions and monthly check-ins over 16 weeks. The study will measure feasibility, a…

This study tests whether adding a peer coach or parent coach to standard eating disorder therapy helps teens aged 12-18 recover faster. 70 participants will receive 12 weeks of therapy plus either a parent coach with patient education materials or patient coaching with parent edu…

This study tests whether a non-invasive procedure called vestibulocortical stimulation (VCS) can reduce pain and improve quality of life in people with fibromyalgia. VCS involves gently irrigating the ear canal with temperate water using a plastic syringe. The trial will compare …

This pilot study tests whether combining a gentle nerve stimulator placed on the ear (taVNS) with robotic tilt-table therapy can safely help people with prolonged disorders of consciousness after severe brain injury. Fifteen participants will undergo 12 weeks of paired therapy, a…

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This small safety trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can safely improve hand and arm function in 10 adolescents with spastic cerebral palsy. Participants will use the device during upper limb rehabilitation sessions. The main…

This study is testing whether cognitive behavioral therapy (CBT) delivered via telehealth can help young people aged 14 to 25 who are at clinical high risk for psychosis. Participants will receive group, family, or individual CBT sessions online. The goal is to see if this approa…

This study is testing whether a special flickering light therapy can improve memory and sleep in people with mild cognitive impairment or early Alzheimer's disease. About 120 participants will be randomly assigned to one of four light conditions and use the light at home for two …

This study tests a new virtual reality treatment for Mal de Débarquement Syndrome (MdDS), a balance disorder causing constant rocking or swaying sensations. Researchers will enroll 200 adults to see if VR can improve symptoms like dizziness and motion sensitivity. The goal is to …

This study tests whether adding suzetrigine, a new non-opioid pain drug, to standard pain management can lower the amount of opioids needed after weight-loss or heart surgery. About 235 adults will be randomly assigned to receive either suzetrigine or a placebo alongside usual ca…

This study is testing whether the immunotherapy drug pembrolizumab can improve quality of life for people with advanced non-small cell lung cancer who are not healthy enough for standard treatments. The trial will enroll 45 patients who have not had prior cancer therapy and have …

This study tests whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique already used for depression, can help people with misophonia tolerate trigger sounds. Sixty adults will each receive two TMS sessions (one inhibitory, one excitatory) targ…

This study tests whether carefully timed lighting can help multiple myeloma patients undergoing their first stem cell transplant. Two hundred participants will receive either bright morning light and dim evening light, or dim light all day. Researchers will measure sleep quality,…

This study tests whether giving a low dose of ephedrine right after an epidural can prevent abnormal fetal heart rate patterns in laboring women. About 100 women requesting labor pain relief will receive either ephedrine or a placebo. The goal is to see if ephedrine reduces the c…

This study tests whether dronabinol, a drug made from cannabis, can reduce chronic pain and inflammation in adults with sickle cell disease. About 60 participants will receive either dronabinol or a placebo to see if it improves pain and quality of life. The goal is to find a new…

This study tests whether rhythmic light therapy can improve brain function and memory in people with mild cognitive impairment. Twenty participants will each try three types of light sessions while their brain activity is measured. The goal is to see if certain light patterns boo…

This study tests a new type of mental training for people with borderline personality disorder (BPD). The training teaches a skill called 'reappraisal-by-distancing' to help control emotions. Researchers will use brain scans to see if the training changes brain activity and will …

This study explores whether music therapy can help children with depression build resilience and ease symptoms. Twenty children will attend 11 music therapy sessions, with some also attending recitals to discuss performance anxiety and self-expression. The goal is to see if these…

This study tests a non-invasive device that stimulates the vagus nerve before meals in teens and young adults (ages 14-22) with anorexia or similar eating disorders. Over 4 weeks, participants receive either real or sham stimulation to see if it boosts meal satisfaction, calorie …

This study tests whether a gentle brain stimulation technique called tDCS can lower cravings in people with cocaine addiction. About 120 adults will receive the stimulation while doing thinking tasks, and brain scans will track changes. The goal is to see if this approach can hel…

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. The device uses flashing lights and tones while measuring heart rate. About 20 participants will use it at home for…

This study tests a noninvasive brain-training technique called neurofeedback in 30 women with bulimia nervosa. Using a wearable headband that measures brain activity, participants receive real-time feedback while eating to improve self-control. The goal is to see if this training…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study tests whether tocilizumab, a drug that blocks inflammation, can help people with major depression who have lost interest or pleasure in things (anhedonia). About 20 adults with depression and signs of immune activation will receive the drug for 8 weeks, while 20 health…

This study tests two different ways of positioning patients during surgery for stones in the upper part of the ureter. One position uses a slight head-down tilt to keep stones from moving back into the kidney, while the other tilts the patient to help clear stones from the kidney…

This study tests whether two HIV antiviral drugs, Truvada and Selzentry, can reduce symptoms in adults with Long COVID. Researchers think hidden viral activity may cause ongoing symptoms. 90 participants will take one of the drugs or a placebo daily for 90 days, and their health …

This study compares two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. Both drugs are given along with a balloon catheter. The goal is to see which drug leads to a faster delivery and whether it increases the chance of a v…

This study tests whether a new pain medication called Suzetrigine can help people who have knee replacement surgery feel less pain and need fewer opioids. About 235 adults will be randomly assigned to get either Suzetrigine or a placebo before surgery. The goal is to see if the d…

This study tests whether a nerve block called a rectus sheath block can reduce pain and the need for strong painkillers after heart surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to receive the block or not. Researchers will measure pain …

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep quality and reduce inflammation in adults with ulcerative colitis who have active inflammation and poor sleep. Thirty participants will wear a sleep tracker, complete surveys, and…

This study tests whether adding ketorolac (an anti-inflammatory) to the standard lidocaine numbing shot reduces pain during office hysteroscopy, a procedure to look inside the uterus. About 60 women with abnormal bleeding will be randomly assigned to get either the combined numbi…

This study tests a virtual reality (VR) headset that uses circadian reset technology to improve sleep and reduce binge eating in 40 adults with binge eating disorder. Participants use the headset for 10 minutes twice daily for one month. Researchers will compare changes in binge …

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. About 25 adults with HIV and long-term pain will use the software at home for 21 days. Researchers will check if it is safe, easy to use, and if it he…

This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from epilepsy patients who also have depression while they play a gambling task. The goal is to identify abnormal brain signals that could guide future …

This study uses brain wave recordings (EEG) and computer models to better understand why people with OCD feel compelled to repeat certain actions. Researchers will compare 50 adults with OCD to 50 healthy volunteers. The goal is to find more precise brain patterns linked to compu…

This study is observing 300 women with female sexual organs who are receiving radiotherapy for certain cancers. Researchers want to understand why some patients have more sexual side effects than others. They will track sexual quality of life and look at radiation doses to find p…

This study will analyze the genetic makeup of tumors from 100 people with relapsed multiple myeloma. Researchers will use advanced DNA and RNA sequencing to find genetic changes and understand how the cancer works. The goal is to gather information that could guide more personali…

This study looks at how tiny plastic particles (microplastics) in our environment might affect gut health and inflammation. Researchers will measure microplastics in stool samples from pregnant women, their families, and healthy volunteers to see if they are linked to Crohn's dis…

This study looks at how a damaged vagus nerve may cause gut problems and inflammation in people with HIV. Researchers will test 207 adults with HIV to see if a drug called pyridostigmine or vagus nerve stimulation can help. The goal is to understand these pathways and find new wa…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study looks at how cannabidiol (CBD), a non-intoxicating cannabis compound, affects stress response in 160 young adults aged 18-25 who experienced early life adversity. Researchers will use brain scans, blood and saliva tests, and stress questionnaires to understand CBD's ef…

This study aims to uncover the genetic and molecular causes of fibromuscular dysplasia (FMD) and related artery conditions (SCAD and CvAD). Researchers will compare tissue and blood samples from 600 patients and healthy volunteers to identify key genes and biological pathways. Th…

This study is testing whether continuous glucose monitors (CGMs) worn during late pregnancy and for two weeks after birth can predict which women with gestational diabetes will have abnormal blood sugar after delivery. Currently, many women skip the standard follow-up test, so re…

This study looks at how things in the environment, like chemicals, might affect thyroid cancer. Researchers will collect blood samples and have 500 participants fill out questionnaires. The goal is to see if certain exposures are linked to worse outcomes, such as cancer coming ba…

This study tests whether offering rapid point-of-care testing for gonorrhea and chlamydia helps more teens get HIV testing and PrEP. About 6,460 adolescents aged 16-24 will be compared: some get rapid testing, others get standard lab testing. The goal is to see if same-day result…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study is testing whether a small device worn in the ear can safely and accurately detect seizures by measuring brain waves. Researchers will first test it in 5 healthy people, then in 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to …

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Researchers will give 30 adults either a high-fructose or high-glucose diet for 12 days and measure changes in their gut microbe…

This study looks at whether social isolation contributes to the early health problems seen in people with schizophrenia, who often die 10–20 years earlier than others. Researchers will follow 650 participants (500 with schizophrenia and 150 siblings) aged 40–70, tracking medical …

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving immunotherapy for cancer. Researchers will measure vitamin D and thyroid function before and during standard cancer treatment. The goal is to see i…

This study follows 170 adults with multiple sclerosis or similar conditions, plus healthy volunteers, for up to 6 years. Researchers use MRI scans, blood tests, and optional spinal taps to track how brain lesions develop and change over time. The goal is to better understand the …

This study looks at how eating changes the brain's ability to control impulses in women with bulimia nervosa. Researchers will use brain scans and computer tasks to understand why binge eating and purging happen. The goal is to find better ways to treat this condition. About 150 …

This study looks at whether pulse oximeters—the clips placed on fingers to measure oxygen levels—work equally well for children with different skin tones who have congenital heart disease. Researchers will enroll 92 children under 18 undergoing heart surgery and compare the oxime…

This study aims to learn more about how changes in the FOXP1 gene affect development, language, and behavior in children and adults. Researchers will use interviews, play-based assessments, and genetic tests to better understand these rare conditions. The study is open to people …

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how blood sugar control relates to complications like wound healing or other transplant outcomes. Participants m…

This study tests two new Siemens imaging prototypes during minimally invasive surgery to remove brain bleeds. Researchers will collect CT scans before, during, and after the procedure to see if the tools help doctors better detect remaining bleeding and blood flow changes. The go…

This study looks at how educational workshops can reduce stress and burnout and improve resilience in community health workers and frontline workers in New York City. About 168 participants will take surveys before and after the program. The goal is to learn what works best to su…

This early-phase study looks at how the antibiotic vancomycin changes gut bacteria and immune cells in people newly diagnosed with multiple sclerosis (MS). Researchers want to understand the connection between gut health and brain inflammation. About 12 participants will take van…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study follows 200 pregnant women with serious mental illness to see how taking antipsychotic medication affects their mental health and their baby's development. Researchers will compare women who take antipsychotics, other psychiatric drugs, or no medication. The goal is to…

This study compares two procedures—thoracentesis (draining fluid with a needle) and pleuroscopy (a camera-guided biopsy of the lung lining)—in 98 adults with suspected cancer-related pleural effusion. The goal is to see which approach provides a usable tissue sample and leads to …

This early-stage study tests whether combining exercise, a natural supplement called spermidine, and either rapamycin or lamivudine is safe and doable for current or former smokers aged 65-80. The goal is to see if this mix can reduce inflammation and slow aging. Only 22 particip…

This study tests a memory support program for Chinese American adults aged 55 and older with mild cognitive impairment (MCI). The program, originally designed for English speakers, will be adapted for Mandarin and Cantonese speakers. The goal is to see if the program is practical…