Icahn School Of Medicine At Mount Sinai

This study looks at whether following the MIND diet—a mix of Mediterranean and DASH diets—can improve brain health and reduce symptoms like fatigue in people with multiple sclerosis (MS). About 100 adults with MS will either follow the MIND diet for one year or continue their usu…

This study tests low-dose methotrexate, a safe and inexpensive drug used for decades in arthritis, as a new treatment for three rare blood cancers: polycythemia vera, essential thrombocythemia, and myelofibrosis. Researchers want to see if adding this pill to current therapy can …

This study tests if dupilumab can help children aged 6-17 with moderate to severe alopecia areata, a condition causing patchy or total scalp hair loss. About 76 participants will receive either dupilumab or a placebo for 48 weeks, followed by an open-label extension. The main goa…

This study tests whether combining two drugs (atezolizumab and bevacizumab) with a type of internal radiation (Y90) can shrink liver tumors enough for patients to qualify for a liver transplant. About 40 adults with liver cancer will receive this treatment. The goal is to see if …

This study is for people who had a stroke a while ago and still have arm or leg weakness. It uses a device that stimulates the vagus nerve in the neck while patients do rehab exercises. The goal is to see if this approach is safe and helps improve movement. About 40 adults will t…

This study tests whether adding a coping skills program to standard biologic medication helps people with Crohn's disease feel better emotionally and physically. About 170 adults with active Crohn's for less than 5 years will be randomly assigned to receive either the coping prog…

This study looks at whether community health workers can help emergency department patients with high blood pressure connect to local services that address social needs like food or housing. Fifteen adults with uncontrolled hypertension will complete surveys and receive referrals…

This study tests four different treatments for people with recurring Clostridioides difficile (C. diff) infections, a serious gut infection that keeps coming back. Researchers will compare a new treatment called MTC01 with fecal microbiota transplant (FMT) in 60 adults. The main …

This study looks at whether adding a blood thinner to standard anti-clotting medicine helps prevent strokes and blood clots in people who develop a new irregular heartbeat after heart bypass surgery. About 3,200 adults will be followed to see if the treatment is safe and effectiv…

This study tests a combination of two drugs, sacituzumab govitecan and cisplatin, in people whose ovarian or endometrial cancer has come back but still responds to platinum-based treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About 5…

This study tests whether a special 'Metabolic Diet' can help women with anorexia nervosa keep a stable weight after they have regained weight. Twenty adult women who recently reached a normal weight will work with a dietitian to follow the diet for 10 weeks. Researchers will moni…

This study is testing if rinsing a piece of bowel with an antiseptic solution during and after bladder removal surgery can prevent urinary tract infections. The rinse is used during the operation and then continued daily for 10-21 days afterward. Researchers will check if this he…

This study tests an oral drug called reparixin in 26 adults with myelofibrosis, a rare bone marrow cancer. Participants have advanced disease and cannot take or refuse standard JAK inhibitor treatment. The goal is to see if reparixin can shrink the spleen, improve blood counts, a…

This study tests whether giving a three-drug combination (hormone therapy, a targeted pill, and an immunotherapy) before prostate removal surgery, followed by more immunotherapy after surgery, can reduce or eliminate cancer left behind. It enrolls 40 men with high-risk prostate c…

This study tests whether a home-based health coaching program can help people with COPD better manage their symptoms and avoid hospital visits. The program includes breathing exercises, medication guidance, and early treatment for flare-ups. Researchers will enroll 300 adults fro…

This study looks at whether adding a special PET/CT scan (rhPSMA-7.3) to the usual MRI can find more aggressive prostate cancers in men with low-risk cancer who are monitoring their condition. About 120 men will get both scans before a biopsy to see which method spots dangerous c…

This study compares two programs designed to help female Veterans who have experienced military sexual trauma or intimate partner violence and also have a history of brain injury. The goal is to see which program works better at improving emotional control and reducing PTSD sympt…

This study tests whether a gentle brain stimulation technique called tDCS can help people with cocaine addiction feel less craving. 120 adults with cocaine use disorder will receive tDCS sessions over 5 weeks while doing cognitive tasks. Researchers will use brain scans to see ho…

This study tests lumbrokinase, a supplement, in 120 adults with Long COVID, post-treatment Lyme disease, or chronic fatigue syndrome (ME/CFS). Participants rate their overall health on a scale from 0 to 100. The goal is to see if lumbrokinase can improve quality of life and daily…

This early-stage study tests whether a non-invasive device that stimulates the vagus nerve, combined with arm exercises, is safe and feasible for teens aged 12-17 with spastic cerebral palsy. Ten participants will receive the paired therapy to see if it can help improve hand and …

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. Researchers want to see if the software is safe, easy to use, and provides some pain relief. About 25 adults with HIV and ongoing pain will use the VR…

This study looks at whether a recreational ballet program can improve movement and coordination in children with autism spectrum disorder (ASD). Researchers will enroll 32 children aged 6-12 with ASD who are not currently taking ballet. Over 12 weeks, the children will participat…

This study tests whether two HIV antiviral drugs can reduce symptoms in adults with Long COVID. 90 participants will take either Truvada, Selzentry, or a placebo pill daily for 90 days. The goal is to see if targeting hidden viral activity improves health and quality of life.

This study tests whether combining a gentle electrical stimulation of the vagus nerve (through the ear) with a robotic tilt table can safely help people with long-term consciousness disorders after brain injury. Fifteen participants will undergo a 12-week program to see if this p…

This study explores whether music therapy can help children with depression build resilience and ease symptoms. Twenty children will attend 11 music therapy sessions, with some also going to recitals to discuss performance anxiety and creativity. The goal is to see if these exper…

This study tests if a personalized, app-based exercise program can reduce symptoms like heart flutters and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with AF who are not very active. Participants will use a sensor to track acti…

This pilot study looks at whether a community navigator can help Black and Latina women with metastatic breast cancer access supportive services like palliative care. About 67 women will be assigned to work with a navigator or receive usual care. The goal is to see if this approa…

This study tests if a gentle brain stimulation technique called TMS can help people with misophonia tolerate trigger sounds better. Sixty adults who are very sensitive to specific sounds will receive two TMS sessions while their brain activity, heart rate, and sweat levels are me…

This study tests two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. The goal is to see which drug, when used with a foley catheter, leads to a faster delivery. Results will help doctors choose the best option for this grou…

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep and reduce inflammation in adults with ulcerative colitis who have active disease and poor sleep. Participants wear a sleep tracker, complete surveys, and provide blood and stool …

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has early-stage dementia. The goal is to see if the program is practical and helps reduce emotional distress. About 50 couples will participate, and the program f…

This study tests a non-invasive device that stimulates the vagus nerve before meals in 30 teens and young adults (ages 14-22) with anorexia or related eating disorders. Over 4 weeks, participants receive either real or sham stimulation to see if it boosts meal satisfaction, calor…

This study tests whether adding dexmedetomidine or epinephrine to spinal anesthesia improves pain relief during and after a planned C-section. Researchers will measure how long the numbness lasts and how quickly women can move their legs again. The goal is to find the better opti…

This study tests whether a rectus sheath block—a type of nerve block—can reduce pain and the need for strong painkillers after heart surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to receive the block or not. Researchers will measure pain…

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. The device uses flashing lights and tones while measuring heart rate. 30 participants will use it at home for 15 mi…

This study tests a noninvasive brain-training technique called neurofeedback in 30 women with bulimia nervosa. Using a wearable headband, participants receive real-time feedback on brain activity while eating, aiming to improve self-control and reduce binge-eating and purging epi…

This study tests a new mental exercise called cognitive reappraisal training for adults with borderline personality disorder. The training teaches people to step back from upsetting thoughts and feelings. Researchers will use brain scans to see if the training changes emotion-rel…

This study tests whether adding a peer coach to standard treatment helps teens aged 12–18 with eating disorders. 70 participants will be randomly assigned to either parent coaching plus patient materials, or parent materials plus patient coaching. The goal is to see if coaching i…

This study tests whether a new pain medication called Suzetrigine can help people who have knee replacement surgery feel less pain and need fewer opioids. About 235 adults will be randomly assigned to get either the new drug or a placebo before surgery. The main goal is to see if…

This study tests whether tocilizumab, a drug that blocks a protein linked to inflammation, can help people with major depression who have lost interest or pleasure in life. About 60 adults with depression and signs of immune activation will receive the drug for 8 weeks. Brain sca…

This study looks at how problems with the vagus nerve (a key nerve connecting the brain and gut) may cause gut issues and inflammation in people with HIV. Researchers will test if a medication called pyridostigmine or vagus nerve stimulation can help. About 207 adults with HIV an…

This study looks at how cannabidiol (CBD), a non-intoxicating cannabis compound, affects stress in 160 young adults aged 18-25 who experienced early life adversity. Researchers will measure brain activity, brain chemicals, and stress hormones after CBD use. The goal is to underst…

This study tests two new Siemens imaging prototypes during minimally invasive surgery for brain hemorrhage. The tools aim to help doctors see how much bleeding remains and assess blood flow after clot removal. About 15 adults having this surgery at Mount Sinai West will participa…

This study looks at whether microplastics in the body can worsen gut inflammation and change the gut microbiome, especially in pregnant women with Crohn's disease. Researchers will measure microplastics in stool samples and analyze gut bacteria. The goal is to understand how envi…

This study looks at whether a continuous glucose monitor (CGM) worn during late pregnancy and for two weeks after birth can predict which women with gestational diabetes will have abnormal blood sugar later. About 40 women will wear a Dexcom G7 CGM and take a standard glucose tes…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study tests a new FDA-approved scanner that gives doctors a fast, detailed view of the surface of prostate tissue during surgery. The goal is to see if it can save at least 20 minutes compared to the current method of checking for leftover cancer cells. About 78 men with int…

This study aims to collect and analyze kidney tissue from 1,000 people with acute or chronic kidney disease, including those with diabetes. By studying the tissue in detail, researchers hope to identify different types of kidney disease and find new targets for treatments. Partic…

This early-stage study tests whether a combination of exercise, a natural supplement called spermidine, and either rapamycin or lamivudine is safe and practical for older smokers (ages 65-80). The goal is to see if these interventions can reduce inflammation and slow aging. Only …

This study looks at how things in our environment, like chemicals, might affect how thyroid cancer grows. Researchers will collect small blood samples and have participants fill out questionnaires to track exposures. The goal is to understand if certain environmental factors are …

This study follows 200 pregnant women with severe mental illness to see how taking antipsychotic medication affects their psychiatric health and their baby's development. Researchers will compare outcomes among women taking antipsychotics, other psychiatric drugs, or no medicatio…

This study aims to better understand why people with obsessive-compulsive disorder (OCD) feel compelled to repeat certain behaviors. Researchers will use computer models and brain wave recordings (EEG) to look at how different parts of the brain work together in 50 adults with OC…

This study looks at how eating influences the brain's ability to exert self-control in women with bulimia nervosa. Researchers will use brain scans and computer tasks to see if predictions about control are altered after eating. The goal is to understand what drives the cycle of …

This study compares two ways to diagnose fluid buildup around the lungs in people with suspected cancer: a needle drainage (thoracentesis) or a scope biopsy (pleuroscopy). Researchers want to see which method provides a better tissue sample and leads to a faster cancer diagnosis …

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases or primary immune deficiencies. Researchers will collect medical records, blood samples, and other data to learn how these treatments work and how t…

This study looks at whether a program called Building Community Resilience (BCR) can help reduce stress and burnout in community health workers and frontline staff in New York City. About 168 participants will attend educational workshops and complete surveys to measure changes i…